MiRNAs in the diagnosis of cardiovascular diseases associated with type 2 diabetes mellitus and obesity
- Authors: Shvangiradze TA1, Bondarenko IZ1, Troshina EA1, Shestakova MV1
-
Affiliations:
- Issue: Vol 88, No 10 (2016)
- Pages: 87-92
- Section: Editorial
- Submitted: 11.04.2020
- Published: 15.10.2016
- URL: https://ter-arkhiv.ru/0040-3660/article/view/32650
- DOI: https://doi.org/10.17116/terarkh201688687-92
- ID: 32650
Cite item
Full Text
Abstract
Worldwide, the number of patients with type 2 diabetes mellitus (T2DM), obesity, and cardiovascular diseases (CVD) continues to increase steadily. Despite long-term studies of obesity and concomitant diseases, the molecular genetic bases for the development of these pathological conditions have remained the subject of numerous investigations so far. Recent investigations point to the involvement of miRNAs as dynamic modifiers of the pathogenesis of various pathological conditions, including obesity, T2DM, and CVD. MicroRNAs are involved in various biological processes underlying the development of CVDs, including endothelial dysfunction, cell adhesion, and atherosclerotic plaque formation and rupture. Some of them are considered as potential sensitive diagnostic markers of coronary heart disease and acute myocardial infarction. Approximately 1,000 microRNAs are found in the human body. It has been determined that miRNAs regulate 30% of all human genes. Among them there are about 50 circulating miRNAs presumably associated with cardiovascular diseases. This review provides recent data on the participation of some miRNAs in various pathological and physiological states associated with CVD in DM and obesity. An extended and exact understanding of the function of miRNAs in the gene regulatory networks associated with cardiovascular risk in obesity will be able to reveal new mechanisms for the progression of disease, to predict its development, and to elaborate innovative therapeutic strategies.
Keywords
References
- Obesity and overweight. 2015. Available at: http://www.who.int/mediacentre/factsheets/fs311/en/.]
- Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, et al. Heart Disease and Stroke Statistics-2014 Update: A Report From the American Heart Association. Circulation. 2013;129(3):e28-e292. doi: 10.1161/01.cir.0000441139.02102.80
- Avrahami D, Kaestner KH, editors. Epigenetic regulation of pancreas development and function. Seminars in cell & developmental biology; 2012: Elsevier.
- Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281-297. doi: 10.1016/s0092-8674(04)00045-5
- Nishiguchi T, Imanishi T, Akasaka T. MicroRNAs and cardiovascular diseases. BioMed Res Int. 2015;2015.
- Weber JA, Baxter DH, Zhang S, Huang DY, How Huang K, Jen Lee M, et al. The MicroRNA Spectrum in 12 Body Fluids. Clin Chem. 2010;56(11):1733-1741. doi: 10.1373/clinchem.2010.147405
- Ishida M, Shimabukuro M, Yagi S, Nishimoto S, Kozuka C, Fukuda D et al. MicroRNA-378 regulates adiponectin expression in adipose tissue: a new plausible mechanism. 2014; e11537
- Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol. 2008;141(5):672-675. doi: 10.1111/j.1365-2141.2008.07077.x
- Silva J, Garcia V, Zaballos A, Provencio M, Lombardia L, Almonacid L, et al. Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival. Eur Respir J. 2010;37(3):617-623. doi: 10.1183/09031936.00029610
- Hoheisel JD, Wang X, Sundquist J, Zöller B, Memon AA, Palmér K et al. Determination of 14 Circulating microRNAs in Swedes and Iraqis with and without Diabetes Mellitus Type 2. PLoS ONE. 2014;9(1):e86792. doi: 10.1371/journal.pone.0086792
- Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005;433(7027):769-773. doi: 10.1038/nature03315
- Sayed ASM, Xia K, Salma U, Yang T, Peng J. Diagnosis, Prognosis and Therapeutic Role of Circulating miRNAs in Cardiovascular Diseases. Heart, Lung and Circulation. 2014;23(6):503-510. doi: 10.1016/j.hlc.2014.01.001
- Wu L, Dai X, Zhan J, Zhang Y, Zhang H, Zhang H et al. Profiling peripheral microRNAs in obesity and type 2 diabetes mellitus. Apmis. 2015;123(7):580-585. doi: 10.1111/apm.12389
- Quiat D, Olson EN. MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment. J Clin Invest. 2013;123(1):11-18. doi: 10.1172/jci62876
- Шестакова М.В. Активность ренин-ангиотензиновой системы (РАС) жировой ткани: метаболические эффекты блокады РАС. Ожирение и метаболизм. 2011;8(1):21-25. doi: 10.14341/2071-8713-5187
- Дедов И.И, Мельниченко Г.А, Бутрова С.А. Жировая ткань как эндокринный орган. Ожирение и метаболизм. 2006;(1):6-13 doi: 10.14341/2071-8713-4937]
- Goossens GH, Blaak EE, van Baak MA. Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders. Obes Rev. 2003;4(1):43-55. doi: 10.1046/j.1467-789X.2003.00091.x
- Boustany CM, Bharadwaj K, Daugherty A et al. Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension. AJP: Regulatory, Integrative and Comparative Physioly. 2004;287(4):R943-R9. doi: 10.1152/ajpregu.00265.2004
- Owens GK. Regulation of differentiation of vascular smooth muscle cells. Physiol Rev. 1995;75(3):487-517.
- Ruhrberg C, Albinsson S, Skoura A, Yu J, DiLorenzo A, Fernández-Hernando C, et al. Smooth Muscle miRNAs Are Critical for Post-Natal Regulation of Blood Pressure and Vascular Function. PLoS ONE. 2011;6(4):e18869. doi: 10.1371/journal.pone.0018869
- Kannel WB. Diabetes and Cardiovascular Disease. The Framingham study. JAMA. 1979;241(19):2035-2038. doi: 10.1001/jama.1979.03290450033020
- Liu J-W, Liu D, Cui K-Z, Xu Y, Li Y-B, Sun Y-M, et al. Recent advances in understanding the biochemical and molecular mechanism of diabetic cardiomyopathy. Biochem Biophys Res Communications. 2012;427(3):441-443. doi: 10.1016/j.bbrc.2012.09.058
- Fang ZY, Prins JB, Marwick TH. Diabetic Cardiomyopathy: Evidence, Mechanisms, and Therapeutic Implications. Endocrine Rev. 2004;25(4):543-567. doi: 10.1210/er.2003-0012
- Grueter CE, van Rooij E, Johnson BA et al. A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13. Cell. 2012;149(3):671-683. doi: 10.1016/j.cell.2012.03.029
- Шестакова М.В. Дисфункция эндотелия — причина или следствие метаболического синдрома?. Российский медицинскийжурнал. 2001;9(2):88-90.
- Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M. MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy. Circ Res. 2007;100(3):416-424. doi: 10.1161/01.res.0000257913.42552.23
- Yang B, Lin H, Xiao J, Lu Y, Luo X, Li B et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nature Med. 2007;13(4):486-491. doi: 10.1038/nm1569
- Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P et al. MicroRNA-133 controls cardiac hypertrophy. Nature Med. 2007;13(5):613-518. doi: 10.1038/nm1582
- Jacobs ME, Wingo CS, Cain BD. An emerging role for microRNA in the regulation of endothelin-1. Fronters in Physiology. 2013;4. doi: 10.3389/fphys.2013.00022
- Feng B, Cao Y, Chen S, Ruiz M, Chakrabarti S. miRNA-1 regulates endothelin-1 in diabetes. Life Scie. 2014;98(1):18-23. doi: 10.1016/j.lfs.2013.12.199
- Capogrossi M, Sabatel C, Malvaux L, Bovy N, Deroanne C, Lambert V et al. MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells. PLoS ONE. 2011;6(2):e16979. doi: 10.1371/journal.pone.0016979
- Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, Prokopi M et al. Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes. Circ Res. 2010;107(6):810-817. doi: 10.1161/circresaha.110.226357
- Fleissner F, Jazbutyte V, Fiedler J, Gupta SK, Yin X, Xu Q et al. Short Communication: Asymmetric Dimethylarginine Impairs Angiogenic Progenitor Cell Function in Patients With Coronary Artery Disease Through a MicroRNA-21-Dependent Mechanism. Circ Res. 2010;107(1):138-143. doi: 10.1161/circresaha.110.216770
- Rayner KJ, Suarez Y, Davalos A, Parathath S, Fitzgerald ML, Tamehiro N et al. MiR-33 Contributes to the Regulation of Cholesterol Homeostasis. Science. 2010;328(5985):1570-1573. doi: 10.1126/science.1189862
- Esau C, Davis S, Murray SF, Yu XX, Pandey SK, Pear M et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab. 2006;3(2):87-98. doi: 10.1016/j.cmet.2006.01.005
- Doran AC, Meller N, McNamara CA. Role of Smooth Muscle Cells in the Initiation and Early Progression of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28(5):812-819. doi: 10.1161/atvbaha.107.159327
- Yang Q, Yang K, Li A. MicroRNA21 protects against ischemia reperfusion and hypoxia reperfusion induced cardiocyte apoptosis via the phosphatase and tensin homolog/aktdependent mechanism. Mol Med Rep. 2014;9:2213-2220.
- Torella D, Iaconetti C, Catalucci D, Ellison GM, Leone A, Waring CD et al. MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and Vascular Remodeling In Vivo. Circ Res. 2011;109(8):880-893. doi: 10.1161/circresaha.111.240150
- Ji R, Cheng Y, Yue J, Yang J, Liu X, Chen H et al. MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation. Circ Res. 2007;100(11):1579-1588. doi: 10.1161/circresaha.106.141986
- Raitoharju E, Lyytikäinen L-P, Levula M, Oksala N, Mennander A, Tarkka M, et al. miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study. Atherosclerosis. 2011;219(1):211-217. doi: 10.1016/j.atherosclerosis.2011.07.020
- Cipollone F, Felicioni L, Sarzani R, Ucchino S, Spigonardo F, Mandolini C, et al. A Unique MicroRNA Signature Associated With Plaque Instability in Humans. Stroke. 2011;42(9):2556-2563. doi: 10.1161/strokeaha.110.597575
- Fan X, Wang E, Wang X, Cong X, Chen X. MicroRNA-21 is a unique signature associated with coronary plaque instability in humans by regulating matrix metalloproteinase-9 via reversion-inducing cysteine-rich protein with Kazal motifs. Exper Molr Pathol. 2014;96(2):242-249. doi: 10.1016/j.yexmp.2014.02.009
- van Rooij E, Sutherland LB, Liu N, Williams AH, McAnally J, Gerard RD et al. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proceedings of the National Academy of Sciences. 2006;103(48):18255-18260. doi: 10.1073/pnas.0608791103
- Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 2008;456(7224):980-984. doi: 10.1038/nature07511
- Patrick DM, Montgomery RL, Qi X, Obad S, Kauppinen S, Hill JA et al. Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J Clin Invest. 2010;120(11):3912-5916. doi: 10.1172/jci43604
- Wang GK, Zhu JQ, Zhang JT, Li Q, Li Y, He J et al. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J. 2010;31(6):659-666. doi: 10.1093/eurheartj/ehq013
- Widera C, Gupta SK, Lorenzen JM, Bang C, Bauersachs J, Bethmann K et al. Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome. J Mol Cell Cardiol. 2011;51(5):872-875. doi: 10.1016/j.yjmcc.2011.07.011