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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cell and Tissue Biology</journal-id><journal-title-group><journal-title xml:lang="en">Cell and Tissue Biology</journal-title><trans-title-group xml:lang="ru"><trans-title>Цитология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0041-3771</issn><issn publication-format="electronic">3034-6061</issn><publisher><publisher-name xml:lang="en">The Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">669636</article-id><article-id pub-id-type="doi">10.31857/S0041377123040107</article-id><article-id pub-id-type="edn">ZKYDBB</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Synaptophysin Expression by Supraependymal Structures of the Rat Brain</article-title><trans-title-group xml:lang="ru"><trans-title>Синаптофизин в супраэпендимных структурах головного мозга крысы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Razenkova</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Разенкова</surname><given-names>В. А.</given-names></name></name-alternatives><email>valeriya.raz@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kirik</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Кирик</surname><given-names>О. В.</given-names></name></name-alternatives><email>valeriya.raz@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Institute of Experimental Medicine</institution></aff><aff><institution xml:lang="ru">Институт экспериментальной медицины</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-07-01" publication-format="electronic"><day>01</day><month>07</month><year>2023</year></pub-date><volume>65</volume><issue>4</issue><fpage>348</fpage><lpage>353</lpage><history><date date-type="received" iso-8601-date="2025-02-27"><day>27</day><month>02</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, В.А. Разенкова, О.В. Кирик</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, В.А. Разенкова, О.В. Кирик</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">В.А. Разенкова, О.В. Кирик</copyright-holder><copyright-holder xml:lang="ru">В.А. Разенкова, О.В. Кирик</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/0041-3771/article/view/669636">https://journals.eco-vector.com/0041-3771/article/view/669636</self-uri><abstract xml:lang="en"><p id="idm45181325932896">Supraependymal plexus in ventricular system is one of the most cryptic structures in the mammalian central nervous system. Since both the topography of supraependymal elements and their functional role remain unclear, the aim of this research was to study the distribution of supraependymal structures within the ventricular system of the rat brain with synaptic function associated marker, synaptophysin. Serial sections of Wistar rats (4–6 month, <italic>n</italic> = 6) forebrain were examined using immunohistochemical detection of synaptophysin and tyrosine hydroxylase. It was shown that supraependymal plexus can form on the surface of ependymal cells synaptophysin-immunopostitive discrete structures, which indicates the formation of synaptic contacts. Although catecholaminergic nerve fibers were present on the ventricular surface in all studied zones, it seems that these nerve fibers may not always contain synaptophysin. Thus, it is assumed that the functional purpose of the supraependymal nerve plexus depends on its localization and can be associated whether with the regulation of ependymal cells and cerebrospinal fluid formation, or with the formation of long-range interneuronal connectivities.</p></abstract><trans-abstract xml:lang="ru"><p id="idm45181325930800">Cупраэпендимное сплетение желудочков головного мозга – одно из самых загадочных структурных образований центральной нервной системы. Поскольку как топография супраэпендимных элементов, так и их функциональное значение остаются неясными, целью настоящего исследования стало изучение распределения супраэпендимных структур в пределах желудочковой системы головного мозга крыс с использованием функционального иммуногистохимического маркера – синаптофизина. С помощью иммуногистохимической реакции на синаптофизин и тирозингидроксилазу были изучены последовательные срезы головного мозга крыс Вистар (4–6 мес., <italic>n</italic> = 6). Показано, что супраэпендимные структуры образуют на апикальной поверхности эпендимоцитов некрупные дискретные скопления, что указывает на зоны формирования синаптических контактов. Установлено, что катехоламинергические волокна присутствуют на поверхности эпендимоцитов всех исследованных областей, при этом наличие нервных волокон на поверхности желудочков не всегда сопряжено с наличием в них синаптофизина. Таким образом предполагается, что функциональное назначение супраэпендимного нервного сплетения зависит от его локализации и может быть связано как с регуляцией функционального статуса эпендимных клеток и формированием состава ликвора, так и с образованием межнейронных синаптических коммуникаций.</p></trans-abstract><kwd-group xml:lang="en"><kwd>synaptophysin</kwd><kwd>ventricular system</kwd><kwd>tyrosine hydroxylase</kwd><kwd>immunohistochemistry</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>синаптофизин</kwd><kwd>желудочки головного мозга</kwd><kwd>тирозингидроксилаза</kwd><kwd>иммуногистохимия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Колос Е.А., Григорьев И.П., Коржевский Д.Э. 2015. Маркер синаптических контактов – синаптофизин. Морфология. Т. 147. № 1. С. 78. (Kolos E.A., Grigoriyev I.P., Korzhevskiy D.E. 2015. A synaptic marker synaptophysin. Morphologija. V. 147. № 1. 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