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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Advances in Current Biology</journal-id><journal-title-group><journal-title xml:lang="en">Advances in Current Biology</journal-title><trans-title-group xml:lang="ru"><trans-title>Успехи современной биологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-1324</issn><issn publication-format="electronic">3034-6347</issn><publisher><publisher-name xml:lang="en">The Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">653199</article-id><article-id pub-id-type="doi">10.31857/S0042132424030033</article-id><article-id pub-id-type="edn">PSBEEY</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Human Health, Environmental Comfort and Well-Being. Part 1. Engineering and Design Resources of the Bioindustry on the Way to Safe Competition with the Resources of Natural Biocenoses and Health-Saving Systems</article-title><trans-title-group xml:lang="ru"><trans-title>Здоровье, экологический комфорт и благополучие человека. Часть 1. Инженерно-дизайнерские ресурсы биоиндустрии на пути к безопасной конкуренции с ресурсами природных биоценозов и систем здоровьесбережения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Suchkov</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Сучков</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Clinical Allergology and Immunology</p></bio><bio xml:lang="ru"><p>кафедра клинической аллергологии и иммунологии</p></bio><email>med_nika2000@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Abe</surname><given-names>H.</given-names></name><name xml:lang="ru"><surname>Абэ</surname><given-names>Х.</given-names></name></name-alternatives><address><country country="JP">Japan</country></address><email>med_nika2000@mail.ru</email><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Murphy</surname><given-names>S.</given-names></name><name xml:lang="ru"><surname>Мёрфи</surname><given-names>Ш.</given-names></name></name-alternatives><address><country country="US">United States</country></address><email>med_nika2000@mail.ru</email><xref ref-type="aff" rid="aff6"/><xref ref-type="aff" rid="aff7"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Smith</surname><given-names>D.</given-names></name><name xml:lang="ru"><surname>Смит</surname><given-names>Д.</given-names></name></name-alternatives><address><country country="US">United States</country></address><email>med_nika2000@mail.ru</email><xref ref-type="aff" rid="aff8"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Polyakova</surname><given-names>V. S.</given-names></name><name xml:lang="ru"><surname>Полякова</surname><given-names>В. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>med_nika2000@mail.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Scherman</surname><given-names>D.</given-names></name><name xml:lang="ru"><surname>Шерман</surname><given-names>Д.</given-names></name></name-alternatives><address><country country="BE">Belgium</country></address><bio xml:lang="en"><p>Unité de Pharmacologie Chimique et Génétique d’Imagerie</p></bio><bio xml:lang="ru"><p>отделение химической фармакологии и генетики визуализации</p></bio><email>med_nika2000@mail.ru</email><xref ref-type="aff" rid="aff9"/><xref ref-type="aff" rid="aff10"/><xref ref-type="aff" rid="aff11"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Glinushkin</surname><given-names>A. P.</given-names></name><name xml:lang="ru"><surname>Глинушкин</surname><given-names>А. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>med_nika2000@mail.ru</email><xref ref-type="aff" rid="aff12"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Barach</surname><given-names>P.</given-names></name><name xml:lang="ru"><surname>Барах</surname><given-names>П.</given-names></name></name-alternatives><address><country country="US">United States</country></address><email>mbikeeva@yandex.ru</email><xref ref-type="aff" rid="aff13"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Terentʼev</surname><given-names>A. O.</given-names></name><name xml:lang="ru"><surname>Терентьев</surname><given-names>А. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>mbikeeva@yandex.ru</email><xref ref-type="aff" rid="aff12"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tan</surname><given-names>M.</given-names></name><name xml:lang="ru"><surname>Тан</surname><given-names>М.</given-names></name></name-alternatives><address><country country="JP">Japan</country></address><email>mbikeeva@yandex.ru</email><xref ref-type="aff" rid="aff14"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Suvorov</surname><given-names>A. N.</given-names></name><name xml:lang="ru"><surname>Суворов</surname><given-names>А. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Microbiology</p></bio><bio xml:lang="ru"><p>кафедра микробиологии СПбГУ</p></bio><email>mbikeeva@yandex.ru</email><xref ref-type="aff" rid="aff15"/><xref ref-type="aff" rid="aff16"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Academy of Natural Sciences</institution></aff><aff><institution xml:lang="ru">Российская академия естественных наук</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian University of Medicine</institution></aff><aff><institution xml:lang="ru">Российский университет медицины</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">New York Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Нью-Йоркская академия наук</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">University of World Politics and Law</institution></aff><aff><institution xml:lang="ru">Университет мировой политики и права</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Abe Cancer Clinic</institution></aff><aff><institution xml:lang="ru">Онкологическая клиника Абэ</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">Massachusetts General Hospital (MGH)</institution></aff><aff><institution xml:lang="ru">Массачусетская больница общего профиля</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">Harvard Medical School</institution></aff><aff><institution xml:lang="ru">Медицинская школа Гарварда</institution></aff></aff-alternatives><aff-alternatives id="aff8"><aff><institution xml:lang="en">Mayo Clinic</institution></aff><aff><institution xml:lang="ru">Клиника Мэйо</institution></aff></aff-alternatives><aff-alternatives id="aff9"><aff><institution xml:lang="en">European Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Европейская академия наук</institution></aff></aff-alternatives><aff-alternatives id="aff10"><aff><institution xml:lang="en">National Center for Scientific Research (CNRS)</institution></aff><aff><institution xml:lang="ru">Национальный центр научных исследований</institution></aff></aff-alternatives><aff-alternatives id="aff11"><aff><institution xml:lang="en">Paris Descartes University</institution></aff><aff><institution xml:lang="ru">Университет Декарта</institution></aff></aff-alternatives><aff-alternatives id="aff12"><aff><institution xml:lang="en">Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Институт органической химии им. Н.Д. Зелинского РАН</institution></aff></aff-alternatives><aff-alternatives id="aff13"><aff><institution xml:lang="en">Wayne State University, School of Medicine</institution></aff><aff><institution xml:lang="ru">Медицинская школа Университета штата Уэйн</institution></aff></aff-alternatives><aff-alternatives id="aff14"><aff><institution xml:lang="en">NAKADA Geriatric Health and Welfare Facilities</institution></aff><aff><institution xml:lang="ru">Гериатрические учреждения здравоохранения и социального обеспечения Накада</institution></aff></aff-alternatives><aff-alternatives id="aff15"><aff><institution xml:lang="en">Institute of Experimental Medicine, Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Институт экспериментальной медицины РАН</institution></aff></aff-alternatives><aff-alternatives id="aff16"><aff><institution xml:lang="en">St. Petersburg State University</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский государственный университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-05-18" publication-format="electronic"><day>18</day><month>05</month><year>2024</year></pub-date><volume>144</volume><issue>3</issue><issue-title xml:lang="ru"/><fpage>291</fpage><lpage>313</lpage><history><date date-type="received" iso-8601-date="2025-02-02"><day>02</day><month>02</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Russian Academy of Sciences</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Российская академия наук</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Russian Academy of Sciences</copyright-holder><copyright-holder xml:lang="ru">Российская академия наук</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/0042-1324/article/view/653199">https://journals.eco-vector.com/0042-1324/article/view/653199</self-uri><abstract xml:lang="en"><p>Everyone has the right to the highest attainable standard of health, and modern preventive, preventive and rehabilitative manipulations promote health and well-being. Thanks to a number of fundamental projects on the study of human health at various levels (genomic, proteomic, and metabolomic), and molecular mechanisms of the development of pathological conditions, there has been a great leap in the field of applied sectors of industrial biotechnology, including segments of the pharmaceutical and food industries, significantly replenished health-saving resources and improved the quality of life of the population. This article will review the advanced achievements of fundamental and applied research, as well as promising areas of the bioindustry.</p></abstract><trans-abstract xml:lang="ru"><p>Каждый человек имеет право на наивысший достижимый уровень здоровья, а современные превентивно-профилактические и реабилитационные манипуляции способствуют укреплению здоровья и благополучия. Благодаря ряду фундаментальных проектов по изучению здоровья человека на различных уровнях (геномном, протеомном и метаболомном) и молекулярных механизмов развития патологических состояний произошел большой скачок в области прикладных секторов промышленной биотехнологии, включая сегменты фармацевтической и пищевой индустрии, существенно пополнив ресурсы здоровьесбережения и повысив качество жизни населения.В данном обзоре будут рассмотрены передовые достижения фундаментально-прикладных исследований, а также перспективные направления биоиндустрии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>personalized and precision medicine</kwd><kwd>translational developments</kwd><kwd>nutritionology</kwd><kwd>biodesign</kwd><kwd>bioinformatics</kwd><kwd>biotechnology</kwd><kwd>genetics</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>персонализированная и прецизионная медицина</kwd><kwd>трансляционные разработки</kwd><kwd>нутрициология</kwd><kwd>биодизайн</kwd><kwd>биоинформатика</kwd><kwd>биотехнология</kwd><kwd>генетика</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Основы персонализированной и прецизионной медицины / Ред. 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