Advances in Current BiologyAdvances in Current BiologyУспехи современной биологии0042-13243034-6347The Russian Academy of Sciences65325610.31857/S0042132423020059KMBVCPArticlesСтатьиRole of Haptoglobin in Protecting the Toxic Effects of Hemoglobin in Various PathologiesРоль гаптоглобина в защите организма от токсического действия внеклеточного гемоглобинаGolubevaM. G.ГолубеваМ. Г.Mgolubeva46@mail.ruLomonosov Moscow State University, Faculty of BiologyМосковский государственный университет им. М.В. Ломоносова, биологический факультет01032023143211412202022025Copyright ©; 2023, Russian Academy of SciencesCopyright ©; 2023, Российская академия наук2023Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0042-1324/article/view/653256

The review presents modern domestic and foreign literature data on the blood plasma protein haptoglobin, its structure, synthesis, function and interaction with hemoglobin. The ability of haptoglobin in interaction with hemoglobin to reduce the toxic effect of the latter is shown. Clinical studies of such interaction in various pathological conditions such as diabetes mellitus, sickle cell anemia, malaria, sepsis, etc. are described. It is noted that the development of new haptoglobin derivatives can contribute to the prevention of hemoglobin toxicity in hemolytic diseases.

Представлены современные отечественные и зарубежные литературные данные о белке плазмы крови гаптоглобине, его строении, синтезе, функции и взаимодействии с гемоглобином. Показана способность гаптоглобина при взаимодействии с гемоглобином снижать токсическое действие последнего. Приводится описание клинических исследований такого взаимодействия при разных патологических состояниях – при сахарном диабете, серповидно-клеточной анемии, малярии, сепсисе и т.д. Отмечается, что разработка новых производных гаптоглобина может способствовать предотвращению токсичности гемоглобина при гемолитических заболеваниях.

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