Advances in Current BiologyAdvances in Current BiologyУспехи современной биологии0042-13243034-6347The Russian Academy of Sciences68722710.31857/S0042132425020012GCYTFZArticlesСтатьиResearch ArticleMonoclonal antibodies to a variable fragment of the T cell receptor – at the service of science and medicineМоноклональные антитела к вариабельному фрагменту Т-клеточного рецептора – на службе у науки и клиникиKhokhlovV. P.ХохловВ. П.
Russian Federation
med9000@mail.ruEngelhardt Institute of Molecular Biology, Russian Academy of SciencesИнститут молекулярной биологии им. В.А. Энгельгардта РАН150420251452931151007202510072025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0042-1324/article/view/687227

This review summarizes recent progress in the engineering of monoclonal antibodies directed to a variable fragment of the T cell receptor with a given mode of action on the targeted subset of T lymphocytes. Since the unique T cell subsets are responsible for the development and outcome of many socially significant diseases the ability of monoclonal antibodies to deplete or expand pathogenetically important T cell families is of a grate interest in clinical practice. The review also discusses the role of the unique T cell families in the pathogenesis of a number of autoimmune and infectious diseases, which provides the prerequisites for the creation of highly effective targeted drugs based on monoclonal antibodies to a variable fragment of the T cell receptor.

Обобщен недавний прогресс в разработке моноклональных антител, направленных на вариабельный фрагмент Т-клеточного рецептора, с заданным способом воздействия на целевую субгруппу Т-лимфоцитов. Поскольку уникальные субгруппы Т-клеток ответственны за развитие и исход многих социально значимых заболеваний, способность моноклональных антител уничтожать или расширять патогенетически важные семейства Т-клеток представляет большой интерес в клинической практике. Также обсуждается роль уникальных семейств Т-клеток в патогенезе ряда аутоиммунных и инфекционных заболеваний, что создает предпосылки для разработки высокоэффективных таргетных препаратов на основе моноклональных антител к вариабельному фрагменту Т-клеточного рецептора.

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