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Synthesis of triethylammonium salts of amidine derivatives of closo-borate anions [B10H10]2– and [B12H12]2– and investigation of their cytotoxic properties

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1. Title Title of document Synthesis of triethylammonium salts of amidine derivatives of closo-borate anions [B10H10]2– and [B12H12]2– and investigation of their cytotoxic properties
2. Creator Author's name, affiliation, country M. N. Ryabchikova; National Research University Higher School of Economics; Russian Federation
2. Creator Author's name, affiliation, country A. V. Nelyubin; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Russian Federation
2. Creator Author's name, affiliation, country I. N. Klyukin; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Russian Federation
2. Creator Author's name, affiliation, country N. Yu. Karpechenko; Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation; Pirogov Russian National Research Medical University; Russian Federation
2. Creator Author's name, affiliation, country A. P. Zhdanov; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Russian Federation
2. Creator Author's name, affiliation, country K. Yu. Zhizhin; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Russian Federation
2. Creator Author's name, affiliation, country N. T. Kuznetsov; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Russian Federation
3. Subject Discipline(s)
3. Subject Keyword(s) closo-dodecaborate anion; cluster boron anions; BNCT; cytotoxicity; MTT test
4. Description Abstract

A series of amidine derivatives of closo-deca- and dodecaborate anions with triethylammonium cations were obtained in this work. The structure of the compounds was established by multinuclear NMR spectroscopy, ESI-mass spectrometry. Cytotoxicity was investigated for all obtained compounds by MTT method on 4 cell lines. It was shown that the nature of the cation does not affect the cytotoxicity of substituted closo-borates.

5. Publisher Organizing agency, location The Russian Academy of Sciences
6. Contributor Sponsor(s) Russian Science Foundation (21-73-10292)
7. Date (DD-MM-YYYY) 18.09.2024
8. Type Status & genre Peer-reviewed Article
8. Type Type Research Article
9. Format File format
10. Identifier Uniform Resource Identifier https://journals.eco-vector.com/0044-457X/article/view/676633
10. Identifier Digital Object Identifier (DOI) 10.31857/S0044457X24090086
10. Identifier eLIBRARY Document Number (EDN) JSUCSO
11. Source Title; vol., no. (year) Žurnal neorganičeskoj himii; Vol 69, No 9 (2024)
12. Language English=en ru
13. Relation Supp. Files Fig. 1. Structure of amidine-closo-borates (188KB)
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
15. Rights Copyright and permissions Copyright (c) 2024 Russian Academy of Sciences