Human PhysiologyHuman PhysiologyФизиология человека0131-16463034-6150The Russian Academy of Sciences66400010.31857/S0131164624030029BVAROQArticlesСтатьиResearch ArticleSlow negative potentials in the pre-stimulus period in norm and patients with the first episode of schizophreniaМедленные негативные потенциалы в предстимульном периоде в норме и у больных с первым эпизодом шизофренииSlavutskayaM. V.СлавуцкаяМ. В.
Russian Federation
mvslav@yandex.ruLebedevaI. S.ЛебедеваИ. С.
Russian Federation
mvslav@yandex.ruFedotovaA. А.ФедотоваА. А.
Russian Federation
mvslav@yandex.ruTikhonovD. V.ТихоновД. В.
Russian Federation
mvslav@yandex.ruKaledaV. G.КаледаВ. Г.
Russian Federation
mvslav@yandex.ruMoscow State UniversityМосковский государственный университет имени М.В. ЛомоносоваCenter for Mental HealthФГБНУ "Центр психического здоровья"16092024503142525022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0131-1646/article/view/664000

Behavioral data (correct response latency and errors number increase) indicate a significant decrease in the task performance efficiency in patients with the first episode of schizophrenia, compared to the norm. At the same time the SNP 1, 2, 3 amplitudes were found to enhance in the patients group, compared to the norm, which may reflect a compensatory activation of predictive attention and inhibition cortical networks for increase the response efficiency. Intergroup differences in the topography of the SNP1 and SNP2 peaks amplitude suggest “disorganization” of the left hemisphere cognitive control cortical networks at the early stage of schizophrenia. It is assumed that the SNP 1, 2, 3 components can be considered as potentially significant clinically markers of cognitive control disorders in schizophrenia.

Поведенческие данные (число и характер ошибочных ответов, ЛП саккад на "Go" стимул) свидетельствуют о существенном снижении эффективности выполнения задания у больных с первым эпизодом шизофрении, по сравнению со здоровыми испытуемыми. При этом в группе больных показано увеличение амплитуды компонентов медленной негативности (МНП1, 2, 3) в односекундном предстимульном интервале, что может отражать компенсаторное усиление активации корковых cетей предиктивного внимания и проактивного торможения для повышения эффективности ответной реакции. Межгрупповые различия в топографии пиков компонентов МНП1 и 2 позволяют предположить "дезорганизацию" кортикальных сетей когнитивного контроля левого полушария на ранней стадии шизофрении. Предполагается, что компоненты МНП1, МНП2 и МНП3 могут рассматриваться как потенциально значимые для клиники маркеры нарушений когнитивного контроля при шизофрении.

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