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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Human Physiology</journal-id><journal-title-group><journal-title xml:lang="en">Human Physiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Физиология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0131-1646</issn><issn publication-format="electronic">3034-6150</issn><publisher><publisher-name xml:lang="en">The Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">664030</article-id><article-id pub-id-type="doi">10.31857/S0131164624010125</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Vitamin D and its effect on the endothelial function of cross-country skiers at various stages of the training cycle</article-title><trans-title-group xml:lang="ru"><trans-title>Витамин D и его влияние на эндотелиальную функцию лыжников-гонщиков на различных этапах тренировочного цикла</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Potolitsyna</surname><given-names>N. N.</given-names></name><name xml:lang="ru"><surname>Потолицына</surname><given-names>Н. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>potol_nata@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Parshukova</surname><given-names>O. I.</given-names></name><name xml:lang="ru"><surname>Паршукова</surname><given-names>О. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>potol_nata@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kalikova</surname><given-names>L. B.</given-names></name><name xml:lang="ru"><surname>Каликова</surname><given-names>Л. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>potol_nata@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bojko</surname><given-names>E. R.</given-names></name><name xml:lang="ru"><surname>Бойко</surname><given-names>Е. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>potol_nata@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Department of Ecological and Medical Physiology, Institute of Physiology, Ural Branch, RAS</institution></aff><aff><institution xml:lang="ru">ФГБУН Институт физиологии ФИЦ Коми НЦ УрО РАН</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-06-04" publication-format="electronic"><day>04</day><month>06</month><year>2024</year></pub-date><volume>50</volume><issue>1</issue><fpage>128</fpage><lpage>138</lpage><history><date date-type="received" iso-8601-date="2025-02-25"><day>25</day><month>02</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Russian Academy of Sciences</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Российская академия наук</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Russian Academy of Sciences</copyright-holder><copyright-holder xml:lang="ru">Российская академия наук</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/0131-1646/article/view/664030">https://journals.eco-vector.com/0131-1646/article/view/664030</self-uri><abstract xml:lang="en"><p>The aim of the study was to assess the level of vitamin D and nitric oxide metabolites, and to search for the relationship between them in cross-country skiers at various stages of the training cycle. During the year, two groups of men (20–26 years old, inhabitants of the Komi Republic) were examined four times: cross-country skiers who are active members of the national teams of the Komi Republic/Russia (n = 11) and office workers (n = 10). It was shown that skiers had higher vitamin D levels duration the year compared to office workers. The fluctuations in the levels of vitamin D, calcium and phosphorus detected in cross-country skiers were seasonal, which could lead to significant changes in the synthesis of nitric oxide and the work of the endothelial system. The greatest number of correlations between the studied metabolites in cross-country skiers was revealed at the beginning and end of the annual training season. A significant imbalance in the levels of vitamin D and nitric oxide metabolites found in them in March may negatively affect the success of performance at important competitions.</p></abstract><trans-abstract xml:lang="ru"><p>В работе исследовали взаимосвязь витамина D и метаболитов оксида азота у высококвалифицированных лыжников-гонщиков на различных этапах тренировочного цикла. В течение года четырехкратно были обследованы две группы мужчин (20–26 лет, жители Республики Коми): лыжники-гонщики, являющиеся действующими членами сборных команд Республики Коми и России (<italic>n</italic> = 11) и офисные работники (<italic>n</italic> = 10). Показано, что у лыжников в течение всего года был более высокий уровень витамина D, по сравнению с офисными работниками. Выявленные у лыжников-гонщиков флуктуации уровня витамина D, кальция и фосфора имели сезонный характер, что могло привести к значительным изменениям в синтезе оксида азота и работе эндотелиальной системы. Наибольшее число корреляций между исследованными метаболитами у лыжников-гонщиков было выявлено в начале и конце годового тренировочного сезона. Обнаруженный у них в марте значительный дисбаланс уровня витамина D и метаболитов оксида азота может негативно отразиться на успешности выступления на важных соревнованиях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>vitamin D</kwd><kwd>nitric oxide</kwd><kwd>endothelial function</kwd><kwd>cross-country skiers</kwd><kwd>inhabitants of the North</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>витамин D</kwd><kwd>оксид азота</kwd><kwd>эндотелиальная функция</kwd><kwd>лыжники-гонщики</kwd><kwd>жители Севера</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">ФНИ</institution></institution-wrap><institution-wrap><institution xml:lang="en">FNI</institution></institution-wrap></funding-source><award-id>ГР АААА-А17-117012310157-7</award-id></award-group></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Vitale J.A., Lombardi G., Cavaleri L. et al. 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