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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Human Physiology</journal-id><journal-title-group><journal-title xml:lang="en">Human Physiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Физиология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0131-1646</issn><issn publication-format="electronic">3034-6150</issn><publisher><publisher-name xml:lang="en">The Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">664094</article-id><article-id pub-id-type="doi">10.31857/S0131164624050092</article-id><article-id pub-id-type="edn">AOCSOW</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Forecast of Professional Success of Employee under Stress Factor: A New Approach</article-title><trans-title-group xml:lang="ru"><trans-title>Прогнозирование профессиональной успешности работника в условиях воздействия трудовых нагрузок: новый подход</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zhukova</surname><given-names>G. V.</given-names></name><name xml:lang="ru"><surname>Жукова</surname><given-names>Г. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>gvivanova@sfu-kras.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sutormin</surname><given-names>O. S.</given-names></name><name xml:lang="ru"><surname>Сутормин</surname><given-names>О. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>gvivanova@sfu-kras.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Stepanova</surname><given-names>L. V.</given-names></name><name xml:lang="ru"><surname>Степанова</surname><given-names>Л. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>gvivanova@sfu-kras.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kratasyuk</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Кратасюк</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>gvivanova@sfu-kras.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Siberian Federal University</institution></aff><aff><institution xml:lang="ru">Сибирский федеральный университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Surgut State University</institution></aff><aff><institution xml:lang="ru">Сургутский государственный университет</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Institute of Biophysics of the Siberian Branch of the RAS</institution></aff><aff><institution xml:lang="ru">Институт биофизики СО РАН</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-11-20" publication-format="electronic"><day>20</day><month>11</month><year>2024</year></pub-date><volume>50</volume><issue>5</issue><fpage>87</fpage><lpage>94</lpage><history><date date-type="received" iso-8601-date="2025-02-25"><day>25</day><month>02</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Russian Academy of Sciences</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Российская академия наук</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Russian Academy of Sciences</copyright-holder><copyright-holder xml:lang="ru">Российская академия наук</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/0131-1646/article/view/664094">https://journals.eco-vector.com/0131-1646/article/view/664094</self-uri><abstract xml:lang="en"><p>A new personalized approach is proposed to predict the professional suitability of railway transport workers under the influence of stressful factors, based on the study of the effect of salivary fluid of subjects before and after a work shift on the intensity of the glow of the bioenzyme reaction of luminous bacteria: NADH:FMN-oxidoreductase+luciferase. The integral method, which signals the magnitude of the stress effect, is based on changes in saliva components such as lactate, ions and cations, as well as nitrate and sulfate chlorides under the influence of stress. This made it possible to identify, using the example of Russian Railways dispatchers, a risk group and a group of stress-resistant workers, which is important to reduce accidents at Russian Railways. The conditions that reduce the stressful workload necessary for the development of effective measures for the prevention of stressful situations and the preservation of workers’ ability to work have been identified.</p></abstract><trans-abstract xml:lang="ru"><p>Предложен новый персонифицированный подход для прогнозирования профессиональной пригодности работников железнодорожного транспорта (РЖД) в условиях воздействия трудовых нагрузок, основанный на исследовании влияния слюнной жидкости испытуемых до и после рабочей смены на интенсивность свечения биферментной реакции светящихся бактерий: НАДН:ФМН-оксидоредуктаза+люцифераза. В основе этого интегрального ферментативного теста, сигнализирующего о величине воздействия трудовых нагрузок на организм, лежит изменение под их влиянием таких компонентов слюны, как лактат, ионы и катионы, а также хлориды нитратов и сульфаты. Это позволило выявить на примере диспетчеров РЖД группу риска и группу адаптированных к нагрузкам работников, что важно для уменьшения аварийности на РЖД. Определены условия, снижающие сверхнормативную рабочую нагрузку и необходимые для разработки эффективных мер в целях профилактики аварийных ситуаций и сохранения трудоспособности работников.</p></trans-abstract><kwd-group xml:lang="en"><kwd>personalized approach</kwd><kwd>work capacity</kwd><kwd>work load</kwd><kwd>stress</kwd><kwd>railway transport</kwd><kwd>risk group</kwd><kwd>health-saving biotechnologies</kwd><kwd>signaling systems</kwd><kwd>saliva</kwd><kwd>bioluminescence</kwd><kwd>stress factors</kwd><kwd>accident rate</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>персонифицированный подход</kwd><kwd>трудоспособность</kwd><kwd>трудовая нагрузка</kwd><kwd>стресс</kwd><kwd>железнодорожный транспорт</kwd><kwd>группа риска</kwd><kwd>здоровьесберегающие биотехнологии</kwd><kwd>сигнальные системы</kwd><kwd>слюна</kwd><kwd>биолюминесценция</kwd><kwd>факторы стресса</kwd><kwd>аварийность</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">Российский научный фонд</institution></institution-wrap><institution-wrap><institution xml:lang="en">Russian Science Foundation</institution></institution-wrap></funding-source><award-id>23-25-10039</award-id></award-group></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Vetter C., Dashti H.S., Lane J.M. et al. 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