Human PhysiologyHuman PhysiologyФизиология человека0131-16463034-6150The Russian Academy of Sciences68402210.31857/S0131164625030034TRWGMHArticlesСтатьиResearch ArticleSlow negative potentials associated with preparation period of memory-guided saccades and antisaccades in healthy individuals and subjects at clinical-high risk for schizophreniaМедленные негативные потенциалы, связанные с подготовкой саккад и антисаккад по памяти, в норме и при клинически высоком риске шизофренииDzhemA. P.ДжемА. П.
Russian Federation
npjam@mail.ruPavlovA. V.ПавловА. В.
Russian Federation
npjam@mail.ruTomyshevA. S.ТомышевА. С.
Russian Federation
npjam@mail.ruOmelchenkoM. A.ОмельченкоМ. А.
Russian Federation
npjam@mail.ruKaledaV. G.КаледаВ. Г.
Russian Federation
npjam@mail.ruSlavutskayaM. V.СлавуцкаяМ. В.
Russian Federation
npjam@mail.ruLebedevaI. S.ЛебедеваИ. С.
Russian Federation
npjam@mail.ruMental Health Research CenterФГБНУ «Научный центр психического здоровья»Moscow State UniversityМосковский государственный университет имени М.В. Ломоносова0407202551328391206202512062025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://journals.eco-vector.com/0131-1646/article/view/684022

The concept of clinical-high risk (CHR) for schizophrenia implies the possibility of identifying a potential predisposition to future schizophrenia manifestation. An important goal of biological psychiatry is conducting research aimed at understanding the neurophysiological mechanisms of this condition. In this study, saccade characteristics of patients at CHR for schizophrenia (n = 15) and healthy participants (n = 15), as well as parameters of their slow negative potentials in the one-second interval preceding the signal to perform a saccade in a “memory-guided saccades/antisaccades” paradigm were analyzed. 12 participants from the CHR group also underwent magnetic resonance imaging (MRI) for subsequent comparison with the control group selected from the laboratory database. Saccade latencies and error rates were higher in the CHR group. There were also found lateral differences in CHR, but not in the control group. However, no between-group differences were observed in studied electrophysiological and MRI parameters. The obtained results may be interpreted as indirect signs of impairments in executive control, interhemispheric asymmetry and connectivity in the CHR group, although further studies are required to determine the possibility of using slow negative potentials parameters as clinical markers.

Концепция клинически высокого риска (КВР) шизофрении подразумевает возможность выявления потенциальной предрасположенности к манифестации шизофрении в будущем. Важной задачей биологической психиатрии является проведение исследований, направленных на понимание нейрофизиологических механизмов данного состояния. Были проанализированы поведенческие показатели больных с КВР шизофрении (n = 15) и здоровых участников (n = 15), а также параметры их медленных негативных потенциалов в односекундном интервале перед сигналом совершить саккаду в парадигме «саккады/антисаккады по памяти». 12 участников из группы КВР шизофрении также прошли обследование с использованием магнитно-резонансной томографии (МРТ) для последующего сравнения с контрольной группой, отобранной из базы данных лаборатории. В группе КВР шизофрении латентный период (ЛП) саккад и количество ошибок были выше, а также были обнаружены латеральные различия, отсутствующие в группе нормы. Тем не менее не было выявлено межгрупповых различий по исследуемым электрофизиологическим и МРТ-параметрам. Полученные результаты могут трактоваться как косвенные признаки нарушений исполнительных функций, межполушарной асимметрии и связанности в группе КВР шизофрении, однако для определения возможности использования параметров медленных негативных потенциалов в качестве клинических маркеров требуются дополнительные исследования.

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