Memory impairment in Alzheimer’s disease
- Authors: Volobuev A.1, Romanchuk P.1, Romanchuk N.1, Davydkln I.1, Bulgakova S.1
-
Affiliations:
- Samara State Medical University
- Issue: Vol 30, No 6 (2019)
- Pages: 10-13
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/113925
- DOI: https://doi.org/10.29296/25877305-2019-06-02
- ID: 113925
Cite item
Abstract
The cerebral cortex (CC) is the syncytium consisting of memory cells (cyclic neural circuits (CNCs)). The latter are continuously loaded with information over the human life span. Various concepts are recalled as a result of CNC excitation. All the CNCs are interconnected. This relationship may be deterministic and stochastic. The stochastic connections of CNCs determine human creative possibilities; they are not available in computers. Alzheimer’s disease is determined by brain neuronal death and CNC destruction. This leads to the disappearance of information in the CC, i.e. to memory impairment. The creative work of the brain and the demand for synaptic connections of brain neurons contribute to the preservation of memory.
Full Text
![Restricted Access](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
About the authors
A. Volobuev
Samara State Medical University
Email: volobuev47@yandex.ru
Professor
P. Romanchuk
Samara State Medical UniversityCandidate of Medical Sciences
N. Romanchuk
Samara State Medical University
I. Davydkln
Samara State Medical UniversityProfessor
S. Bulgakova
Samara State Medical University
References
- Carola R., Harley J., Nobac C. Human Anatomy and Physiology / New York, London, Paris: McGraw-Hilll Publishing Company, 1990; p. 380, 387.
- Физиология человека. Под ред. Г.И. Косицкого 3-е изд. / М.: Медицина, 1995; с. 142
- Хьюбел Д., Стивенс Ч., Кэндел Э. и др. Мозг. Пер. с англ. / М.: Мир, 1987
- Волобуев А.Н., Пятин В.Ф., Романчук Н.П. и др. Когнитивная дисфункция при перевозбуждении структур головного мозга // Врач. - 2018; 29 (9): 17-20 [Volobuev A., Pyatin V., Romanchuk N. et al. Cognitive dysfunction in the overexcitation of brain structures // Vrach. - 2018; 29 (9): 17-20 (in Russ.)]. https://doi.org/10.29296/25877305-2018-09-04.
- Гайтон А.К., Холл Дж. Э. Медицинская физиология. Пер. с англ. / М.: Логосфера, 2008
- Masliah E., Mallory M., Hansen L. Quantitative synaptic alterations in the human neocortex during normal aging // Neurology. - 1993; 43: 192-7.
- Gibson P. EM study of the number of cortical synapses in the brains of aging people and people with Alzheimer-type dementia // Acta Neuropathologica. - 1983; 62: 127-33.
Supplementary files
![](/img/style/loading.gif)