THE DYNAMICS OF THE PSYCHOLOGICAL STATUS IN HELICOBACTER PYLORI-INFECTED PATIENTS WHEN USING DIFFERENT ERADICATION THERAPY REGIMENS


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Abstract

Objective: to evaluate the efficacy of probiotics in addition to standard treatment in improve the psychological status of patients with chronic gastroduodenitis (CGD) associated with Helicobacter pylori (Hp). Materials and methods: 75 patients underwent standard eradication therapy (SET): omeprazole 20 mg, amoxicillin 1000 mg, clarithromycin 500 mg BID for days. Patients in group 1 (n=23) additionally received a biologically active supplement (BAS) with the probiotic mechanism Enterococcus faecium L-3 3 tablets TID for 4 weeks; patients in group 2 (n=32) - dietary supplements with the probiotic Bacillus subtilis in a dose of 2 capsules BID for 4 weeks; patients of the comparison group (n=20) - only SET. In addition to a complete gastroenterological examination and verification of Hp, patients underwent a psychological examination before and 1.5-2 months after treatment using special questionnaires to assess anxiety, depression, asthenia, and quality of life. Results: in both experimental groups there was a more significant improvement in the quality of life than in the comparison group (p<0.05). In patients receiving Enterococcus faecium L-3 reduction of psychopathological symptoms was achieved mainly due to a decrease in anxiety-depressive disorders and in patients receiving Bacillus subtilis due to a decrease in the severity of asthenic manifestations. In the comparison group no significant improvements in psychological status were identified. Conclusion: the use of probiotics in treatment of CGD associated with Hp improves the indicators of psychological functioning and quality of life of patients.

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About the authors

Yu. Uspensky

Saint Petersburg State Pediatric Medical University; Acad. I.P. Pavlov First Saint Petersburg State Medical University

Professor MD

I. Gorbacheva

Acad. I.P. Pavlov First Saint Petersburg State Medical University

Professor MD

N. Baryshnikova

Acad. I.P. Pavlov First Saint Petersburg State Medical University; Institute of Experimental Medicine

Email: baryshnikova_nv@mail.ru
Candidate of Medical Sciences

S. Akaeva

Acad. I.P. Pavlov First Saint Petersburg State Medical University

A. Gnutov

Saint Petersburg State Pediatric Medical University

M. Rustamov

Belarusian State Medical University

Minsk, Belarus

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