VASCULAR ENDOTHELIAL DYSFUNCTION AS A RISK FACTOR FOR EXCESSIVE BLOOD PRESSURE ELEVATION IN RESPONSE TO STRESS IN YOUNG PEOPLE


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Abstract

Objective. To identify the relationship blood pressure (BP) elevation during stress and the endothelial functional in young people. Materials and methods. The investigation enrolled 980 Gorky Donetsk National Medical University students. Blood pressure was measured by the standard method 30 minutes before and during stress. Examination was a stressful factor. The stress-induced increase in systolic and/or diastolic blood pressures (SBP and DBP) by >25% of the initial level was considered excessive. The brachial artery reactive hyperemia test was used to evaluate endothelial function. The increase in the brachial artery diameter by <10% of the initial level was considered insufficient. Statistical data were processed on a personal computer in the licensed package of the MedStat program. Results. The >25% stress-induced increase in SBP was detected in 50 (6.5%) examined patients and that in DBP was found in 53 (6.9%). In general, there was a pathological stress-induced blood pressure reaction in 59 (7.7%) examined patients. Ninety (11.8%) examined patients demonstrated an insufficient (<10%) increase in the brachial artery diameter after cuff removal. According to the simple linear regression analysis results, the insufficient increase in the brachial artery diameter in the reactive hyperemia test was a significant risk factor for an excessive blood pressure elevation in response to stress (odds ratio, 4.65; 95% confidence interval, 2.57-8.42) (p<0.05). Conclusion. Endothelial dysfunction is a risk factor for excessive blood pressure elevation in response to stress in young people.

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About the authors

E. V Sklyannaya

M. Gorky Donetsk National Medical University

Email: elena_skl1979@mail.ru
Candidate of Medical Sciences Donetsk People’s Republic, Ukraine

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