EFFECT OF NATURAL PRODUCTS ON THE ATHEROGENIC MODIFICATION OF LDL
- Authors: Azarova I.1, Feoktlstov A.1, Orekhov A.1,2
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Affiliations:
- Institute for Atherosclerosis Research
- Research Institute of General Pathology and Pathophysiology
- Issue: Vol 25, No 4 (2014)
- Pages: 80-82
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/115974
- ID: 115974
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Abstract
Modified low-density lipoproteins (LDL) stimulate cholesterol accumulation in the cells of blood vessels, favoring the development of atherosclerosis. The enzyme trans-sialidase induces atherogenic modification of LDL. This investigation has studied the effect of extracts from natural products on plasma trans-sialidase activity.
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About the authors
I. Azarova
Institute for Atherosclerosis Research
Email: irina.nik.azarova@gmail.com
A. Feoktlstov
Institute for Atherosclerosis ResearchCandidate of Biological Sciences
A. Orekhov
Institute for Atherosclerosis Research; Research Institute of General Pathology and PathophysiologyProfessor
References
- Orekhov A., Tertov V., Mukhin D. Desialylated low density lipoprotein -naturally occurring lipoprotein with atherogenic potency // Atherosclerosis. - 1991; 86: 153-61.
- Orekhov A., Tertov V., Mukhin D. et al. Modification of low density lipoprotein by desialylation causes lipid accumulation in cultured cells. Discovery of desialylated lipoprotein with altered cellular metabolism in the blood of atherosclerotic patients // Biochem. Biophys. Res. Commun. - 1989; 162: 206-11.
- Lowry O., Rosebrough N., Farr A. et al. Protein measurement with the Folin phenol reagent // J. Biol. Chem. - 1951; 193: 265-75.
- Millar J. The sialylation of plasma lipoproteins // Atherosclerosis. - 2011; 154: 1-13.
- Tertov V., Kaplun V., Sobenin I. et al. Human plasma trans-sialidase causes atherogenic modification of low density lipoprotein // Atherosclerosis. - 2001; 159: 103-15.
- Tertov V., Sobenin I., Tonevitsky A. et al. Isolation of atherogenic modified (desialylated) low density lipoprotein from blood of atherosclerotic patients: separation from native lipoprotein by affinity chromatography // Biochem. Biophys. Res. Commun. - 1990; 167: 1122-7.
- Taniguchi T., Ishikava Y., Tsunemitsu M. et al. Stimulation of cholesteryl ester synthesis in human monocyte-derived macrophages by asialo low density lipoproteins // Arteriosclerosis. - 1989; 9: 767.
- Tertov V., Kaplun V., Sobenin I. et al. Low-density lipoprotein modification occurring in human plasma. Possible mechanism of in vivo lipoprotein desialylation as a primary step of atherogenic modification // Atherosclerosis. - 1998; 138: 183-95.
- Veh R., Corfield A., Sander M. et al. Neuraminic acid-specific modification and tritium labelling of gangliosides // Biochem. Biophys. Acta. - 1977; 486: 145-60.
- Dixon W., Brown M. Biomedical Computer Programs. P-Series. University of California Press, Berkeley. 1977; 185-203.
- Schenkman S. Structural and functional properties of trypanosoma transsialidase // Annu. Rev. Microbiol. - 1994; 48: 499-523.
- Agusti R., Paris G., Ratier L. et al. Lactose derivatives are inhibitors of Trypanosoma crusi trans-sialidase activity toward conventional substrates in vitro and in vivo // Glycobiology. - 2004; 14 (7): 659-70.
- Tertov V., Orekhov A., Sobenin I. et al. Carbohydrate content of protein and lipid components in sialic acid-rich and -poor low density lipoptoteins from subjects with and without coronary artery disease // J. Lipid. Res. - 1993; 34: 365-75.
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