Early diagnosis of acute kidney dysfunction in combined mechanical injury (literature review)

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Abstract

The improvement of clinical and laboratory research methods contributes to the timely diagnosis and improvement of the effectiveness of disease therapy, which ensures the preservation of public health, reducing the time of temporary disability and rehabilitation of patients. The evidence base for determining the predictive role of biomarkers of renal dysfunction is small and is available only for a very limited number of substances – some serum proteins, the synthesis of which increases with acute kidney injury, low molecular weight urine proteins, intracellular enzymes of tubular epithelial cells and some other substances. This article provides an overview of modern laboratory methods of early diagnosis of kidney dysfunction in combined mechanical injury.

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About the authors

А. А. Ivanov

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

Author for correspondence.
Email: rusfanstar@mail.ru
ORCID iD: 0000-0003-1009-6096
Russian Federation, Saint Petersburg

S. V. Gaiduk

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

Email: rusfanstar@mail.ru
ORCID iD: 0000-0003-1524-9493

MD

Russian Federation, Saint Petersburg

V. А. Pershko

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

Email: rusfanstar@mail.ru
ORCID iD: 0000-0003-1492-6667

Candidate of Medical Sciences

Russian Federation, Saint Petersburg

Е. V. Petrova

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

Email: rusfanstar@mail.ru
ORCID iD: 0000-0002-1844-8490
Russian Federation, Saint Petersburg

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2. Fig. 1. RIFLE staging classification of acute kidney injury

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3. Fig. 2. Prognostic evaluation of marker detection at different stages of acute kidney injury in biomaterials

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