Prospects for the use of a combined agent with prebiotic action to improve the effectiveness of type 2 diabetes therapy

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Abstract

Type 2 diabetes mellitus is a chronic disease characterized by impaired insulin secretion in the body and loss of tissue sensitivity to it. Treatment of the disease is still not effective enough, which is due to the multifactorial nature of the development of carbohydrate metabolism disorders, the mechanisms of which have not yet been fully elucidated. Also, the complexity of its treatment is associated with the occurrence of side effects when taking first-line drugs. Among the most important complications is a decrease in the concentration of several groups of vitamins that play a key role in maintaining the health of the body and metabolic processes, including participation in the regulation of blood glucose levels. Studies show that a deficiency of vitamins D, B12, C and some others can increase the risk of developing diabetes progression. Therefore, it is important to maintain a balance of vitamins in the body through proper nutrition or taking vitamin complexes, such as Mezi-Vit Plus.

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About the authors

P. V. Seliverstov

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

Author for correspondence.
Email: val9126@mail.ru
ORCID iD: 0000-0001-5623-4226

Associate Professor, Candidate of Medical Sciences

Russian Federation, Saint Petersburg

I. M. Efimov

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

Email: val9126@mail.ru
ORCID iD: 0000-0002-0844-3936

Associate Professor, Candidate of Medical Sciences

Russian Federation, Saint Petersburg

V. P. Kutsenko

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: val9126@mail.ru
ORCID iD: 0000-0001-9755-1906

Candidate of Medical Sciences

Russian Federation

P. Y. Klimenko

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: val9126@mail.ru
ORCID iD: 0009-0003-7055-8608
Russian Federation

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2. Fig. 1. Mechanism of action of metformin [7]

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3. Fig. 2. Changes in the composition of intestinal microbiota by metformin and regulation of glucose homeostasis [9]

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4. Fig. 3. Vitamin B12 content in the liver and kidneys after metformin treatment [10]

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5. Fig. 4. The cycle of transformations of B vitamins [13]

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6. Fig. 5. Activation of vitamin D by vitamin C

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7. Fig. 6. The impact of vitamin D deficiency on the incidence of type 2 diabetes mellitus [19]

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8. Fig. 7. Pathogenic mechanisms causing vitamin D deficiency associated with insulin resistance [20]

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