Modification of mesh endoprostheses for hernioplasty by electrospinning method

Objecties. The improvement of biocompatibility of polypropylene mesh endoprostheses for hernioplasty. Materials and methods. The endoprostheses based on tricot polypropylene meshes of standard and low density are investigated. The solution of polycaprolactone in chloroform and electrospinning method were used for the surface modification. The specimens were sterilized in low-temperature hydrogen peroxide plasma. Structural analysis of modified surface was performed by scanning electron microscopy, the strain-strength parameters of endoprostheses were determined in mechanical tests on uniaxial tension. Results. Micro-sized spatial fibrous structure of polycaprolactone as a modiftiator was formed on the surface of polypropylene mesh by electrospinning that allowing to increase the biocompatibility of reticular endoprostheses for hernioplasty on retention of strain-strength properties of issues. Conclusion. In order to increase the biocompatibility of polypropylene mesh endoprostheses for hernioplasty, the parameters of the technological mode of modifying the surface of a knitted prosthetic mesh by forming an adhesively bonded microstructured fibrous polymer modifier are optimized. The required porosity of the endoprosthesis structure, uniformity of distribution and adhesion of the modifier to the knitted base are provided during the modification process. To obtain a fibrous structure from a 7.5% polycaprolactone solution on by electrospinning, the optimal mode parameters are: voltage 30 kV, distance between electrodes 10 cm and application rate 14 cm/min.

mesh endoprosthesis, structural modifying, polycaprolactone, electrospinning, deformational and biocompatibility