Differential diagnosis for urinary stones of different chemical composition, by using dual energy computed tomography

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详细

The use of dual energy computed tomography (DECT) has become widespread in urology, including in the diagnosis of urolithiasis. DECT makes it possible to visualize and differentiate urinary stones of different chemical density and composition from each other. Studies have shown the advantages of DECT not only in the detection, but also in the differentiation of the main groups of urinary stones. At the same time, a number of in vivo studies evaluate DECT as a technique for the high-accuracy differential diagnosis of urate stones. The accuracy of diagnosing urate stones with DECT reaches 92-100%, as confirmed by sensitivity (84.6-98.4%) and specificity (100%).

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作者简介

V. Ryazanov

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: val9126@mail.ru

MD

俄罗斯联邦, Saint Petersburg

V. Kutsenko

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: val9126@mail.ru

Candidate of Medical Sciences

俄罗斯联邦, Saint Petersburg

G. Sadykova

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: val9126@mail.ru

Candidate of Medical Sciences

俄罗斯联邦, Saint Petersburg

S. Menshikova

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: val9126@mail.ru
俄罗斯联邦, Saint Petersburg

P. Seliverstov

S.M. Kirov Military Medical Academy

Email: val9126@mail.ru

Candidate of Medical Sciences

俄罗斯联邦, Saint Petersburg

S. Bagnenko

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia; S.M. Kirov Military Medical Academy

Email: val9126@mail.ru

MD

俄罗斯联邦, Saint Petersburg; Saint Petersburg

A. Nikolaev

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: val9126@mail.ru
俄罗斯联邦, Saint Petersburg

R. Postanogov

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: val9126@mail.ru
俄罗斯联邦, Saint Petersburg

A. Libert

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: val9126@mail.ru
俄罗斯联邦, Saint Petersburg

参考

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  2. Kapanadze L.B., Serova N.S., Rudenko V.I., et al. Experience of using dual-energy computed tomography in patient with urolithiasis. Medical Visualization. 2018; 4: 59–64 (in Russ.). doi: 10.24835/1607-0763-2018-4-59-64
  3. Kapanadze L.B., Serova N.S., Rudenko V.I. et al. Results of application of dual-energy computed tomography in the diagnosis of urolithiasis. REJR. 2018; 8 (2): 94–104 (in Russ.). doi: 10.21569/2222-7415-2018-8-2-94-104
  4. Nazarov T.K., Rychkov I.V., Lebedev D.G., Trubnikova K.E. Comparative analysis of data from a dual-energy computer tomograph and the results of a mineralogical research of urinary stones. Diagnostic radiology and radiotherapy. 2018; 2: 54–8 (in Russ.). doi: 10.22328/2079-5343-2018-9-2-54-58
  5. Lopatkin N.A. Urology. Ed. N.A. Lopatkina. M.: GEOTAR-Media, 2011; 1024 s. (in Russ.).
  6. Appel E., Thomas C., Steuwe A. et al. Evaluation of split-filter dual-energy CT for characterization of urinary stones. Br J Radiol. 2021; 94 (1127): 20210084. doi: 10.1259/bjr.20210084
  7. Erdogan H., Temizoz O., Koplay M. et al. In Vivo Analysis of Urinary Stones With Dual-Energy Computed Tomography. J Comput Assist Tomogr. 2019; 43 (2): 214–9. doi: 10.1097/RCT.0000000000000831
  8. McGrath T.A., Frank R.A., Schieda N. et al. Diagnostic accuracy of dual-energy computed tomography (DECT) to differentiate uric acid from non-uric acid calculi: systematic review and meta-analysis. Eur Radiol. 2020; 30: 2791–801. doi: 10.1007/s00330-019-06559-0
  9. Nourian A., Ghiraldi E., Friedlander J.I. Dual-Energy CT for Urinary Stone Evaluation. Curr Urol Rep. 2021; 22 (1): 1. doi: 10.1007/s11934-020-01019-5
  10. Ogawa N., Sato S., Ida K. et al. Evaluation of Urinary Stone Composition and Differentiation between Urinary Stones and Phleboliths Using Single-source Dual-energy Computed Tomography. Acta Med Okayama. 2017; 71 (2): 91–6. doi: 10.18926/AMO/54976
  11. Rompsaithong U., Jongjitaree K., Korpraphong P. et al. Characterization of renal stone composition by using fast kilovoltage switching dual-energy computed tomography compared to laboratory stone analysis: a pilot study. Abdom Radiol. 2019; 44: 1027–32. doi: 10.1007/s00261-018-1787-6
  12. Shalini S., Kasi Arunachalam V., Kumar Varatharajaperumal R. et al. The role of third-generation dual-source dual-energy computed tomography in characterizing the composition of renal stones with infrared spectroscopy as the reference standard. Pol J Radiol. 2022; 87 (1): 172–6. doi: 10.5114/pjr.2022.114841

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2. Fig. 1. Three patients with nephrolithiasis: a – right uric acid stone on conventional CT scan is seen as (b) red on the corresponding DECT image; c – left non-uric acid stone is visualized as blue on the DECT image; d – mixed composition left lower pole stone seen as both red and blue on the DECT image (source [9])

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3. Fig. 2. In a 60-year-old patient, a 22×12-cm stone (arrow) is seen in the bladder lumen in the unenhanced axial CT image (a). The stone is coded with pink, consistent with uric acid stone in axial (b) and 3D reformatted (c) images, which were obtained at high and low kVp values and analyzed at the workstation; d – when this stone, the attenuation rate of which are calculated as 0.96 at different kVp values, is positioned on the graphics on which cutoff values are shown, the stone is seen to be coherent with uric acid stone; b – the yellow circle in the second image shows the scanned area (FOV) belonging to the second tube, on which an evaluation can be made with dual energy (source [7])

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4. Fig. 3. With the help of DECT, in the lower group of calyxes of the left kidney, a 10,9×11,2 cm and 535 cm3 irregular rounded calculus is visible. Estimated chemical composition: mixed stone (purple color) with a predominance of the uric acid component (source [2])

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