Epicardial fat ectopy in women with different estradiol levels
- 作者: Zimina M.1, Dora S.1, Lygdenova I.1, Yusipova T.1, Butomo M.1, Volkova A.1, Khalimov Y.1
-
隶属关系:
- I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
- 期: 卷 35, 编号 1 (2024)
- 页面: 44-46
- 栏目: From Practice
- URL: https://journals.eco-vector.com/0236-3054/article/view/626888
- DOI: https://doi.org/10.29296/25877305-2024-01-08
- ID: 626888
如何引用文章
详细
Objective. To establish the early risk factors of metabolic syndrome in women with decreased ovarian reserve, premature and early menopause; to estimate the thickness of epicardial fat and the levels of estradiol and anti-mullerian hormone (AMH) in women with early estrogen deficiency and in control subjects without estrogen deficiency, to evaluate the effect of estrogen replacement hormone therapy on epicardial fat thickness and the change of arterial pressure (BP) parameters.
Material and Methods. Group 1 (n=12) included patients with co-preserved menstrual cycle and AMH >1 ng/ml, Group 2 (n=10) included patients with preserved menstrual cycle and AMH <1 ng/ml, Group 3 (n=12) included patients with premature menopause, Group 4 (n=13) included patients with early menopause. The level of the studied parameters in blood serum was determined by immunochemiluminescence assay. Epicardial fat thickness was determined on VIVID E90 machine in 3 cardiac cycles with subsequent calculation of the mean value.
Results. An increase in epicardial fat thickness was detected in Groups 2–4 with low estradiol levels compared to group 1 (p=0.01). Patients with normal body mass index and with estrogen deficiency also show increased epicardial fat thickness.
全文:
作者简介
M. Zimina
I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: rita.zimina.1997@mail.ru
ORCID iD: 0009-0006-5004-2825
俄罗斯联邦
S. Dora
I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Email: rita.zimina.1997@mail.ru
ORCID iD: 0000-0002-8249-6075
MD
俄罗斯联邦I. Lygdenova
I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Email: rita.zimina.1997@mail.ru
ORCID iD: 0009-0004-0675-2104
俄罗斯联邦
T. Yusipova
I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Email: rita.zimina.1997@mail.ru
Candidate of Medical Sciences
俄罗斯联邦M. Butomo
I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Email: rita.zimina.1997@mail.ru
ORCID iD: 0000-0003-2506-0862
Candidate of Medical Sciences
俄罗斯联邦A. Volkova
I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Email: rita.zimina.1997@mail.ru
ORCID iD: 0000-0002-5189-9365
MD
俄罗斯联邦Yu. Khalimov
I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Email: rita.zimina.1997@mail.ru
ORCID iD: 0000-0002-7755-7275
Professor, MD
俄罗斯联邦参考
- Ford E.A., Beckett E.L., Roman S.D. et al. Advances in human primordial follicle activation and premature ovarian insufficiency. Reproduction. 2020; 159 (1): R15–R29. doi: 10.1530/REP-19-0201
- Rudnicka E., Kruszewska J., Klicka K. et al. Premature ovarian insufficiency – aetiopathology, epidemiology, and diagnostic evaluation. Prz Menopauzalny. 2018; 17 (3): 105–8. doi: 10.5114/pm.2018.78550
- Golezar S., Ramezani Tehrani F. et al. The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis. Climacteric. 2019; 22 (4): 403–11. doi: 10.1080/13697137.2019.1574738
- Paschou S.A., Augoulea A. Lambrinoudaki I. Premature ovarian insufficiency. Eur Gynecol Obst J. 2020; 2: 5–9.
- Conway G.S. Premature ovarian insufficiency, menopause, and hormone replacement therapy. In: Advanced Practice in Endocrinology Nursing. Cham: Springer International Publishing, 2019; рр. 803–15. doi: 10.1007/978-3-319-99817-6_41
- Хабибулина М. Психовегетативный статус и безболевая ишемия миокарда в пременопаузе при метаболически здоровом ожирении. Врач. 2019; 30 (4): 79–83 [Khabibulina M. Psychoautonomic status and silent myocardial ischemia in premenopause in the presence of metabolically healthy obesity. Vrach. 2019; 30 (4): 79–83 (in Russ.)]. doi: 10.29296/25877305-2019-04-15
- Хабибулина М.М. Влияние альтернативного варианта заместительной гормональной терапии на кардиальные проявления при метаболически здоровом ожирении и гипоэстрогенемии. Фармация. 2022; 71 (4): 46–51 [Khabibulina M.M. The influence of an alternative variant of hormone replacement therapy on cardiac manifestations in metabolically healthy obesity and hypoestrogenemia. Pharmacy. 2022; 71 (4): 46–51 (in Russ.)]. doi: 10.29296/25419218-2022-04-07
- Iacobellis G. Epicardial Adipose Tissue: From Cell to Clinic. Contemporary Cardiology. SpringerLink, 2020; 191 р. doi: 10.1007/978-3-030-40570-0
- Wong C.X., Ganesan A.N., Selvanayagam J.B. Epicardial fat and atrial fibrillation: current evidence, potential mechanisms, clinical implications, and future directions. Eur Heart J. 2017; 38 (17): 1294–302. doi: 10.1093/eurheartj/ehw045
- Sacks H., Symonds M.E.. Anatomical Locations of Human Brown Adipose Tissue: Functional Relevance and Implications in Obesity and Type 2 Diabetes. Diabetes. 2013; 62 (6): 1783–90. doi: 10.2337/db12-1430
- Frayn, Keith N. 2013. Metabolic Regulation: A Human Perspective, 3rd Edition. doi: 10.1016/j.clnu.2010.12.002
- Poetsch M.S., Strano A., Guan K. Role of Leptin in Cardiovascular Diseases. Front Endocrinol. 2020; 11: 354. doi: 10.3389/fendo.2020.00354
- Landecho M.F., Tuero C., Valenti V. et al. Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk. Nutrients. 2019; 11 (11): 2664. doi: 10.3390/nu11112664