The state of lipid peroxidation and antioxidant protection in adolescents with recurrent headache: the possibility of correction

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Objective. To evaluate the parameters of the lipid peroxidation system (POL) and antioxidant protection system (AOP) in adolescents with recurrent headache syndrome (RH).

Materials and methods. 104 adolescents (boys and girls) aged 12–17 years were examined, of which 66 adolescents with RH (the main group) and 38 without RH (the comparison group). The presence of RH was verified by a screening questionnaire, the content of the indicators of the POL-AOР system was determined by spectrophotometric methods. The received data is processed in the program Statistica 12.

Results. Adolescents with RH had higher levels of malonic dialdehyde (MDA) in blood plasma and red blood cells; decreased activity of plasma and erythrocyte superoxide dismutase (SOD), and lower levels of protein in blood plasma. The presence of RH in adolescents is associated with a larger number of individuals characterized by high plasma and erythrocyte concentrations of MDA, low plasma and erythrocyte SOD activity, and low glutathione-S-transferase activity. The authors highlight the possibilities of correcting oxidative stress using antioxidants.

Conclusion. RH in adolescents is associated with a higher content of pro-oxidant – MDA in plasma and red blood cells, a lower activity of the antioxidant enzyme – SOD in plasma and red blood cells, which indicates a greater severity of oxidative stress in this contingent. The group with RH has a higher number of adolescents with the above-mentioned shifts in the gender-AGE system than among their peers without RH. It is advisable to prescribe antioxidants to correct the manifestations of oxidative stress in adolescents with RH.

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作者简介

Yu. Kostyuchenko

Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North

编辑信件的主要联系方式.
Email: potupchik_tatyana@mail.ru
ORCID iD: 0000-0001-6233-6472
SPIN 代码: 7480-2064
俄罗斯联邦, Krasnoyarsk

T. Potupchik

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru
ORCID iD: 0000-0003-1133-4447
SPIN 代码: 8353-3513

Candidate of Medical Sciences

俄罗斯联邦, Krasnoyarsk

L. Evert

Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North; N.F. Katanov Khakass State University, Ministry of Education and Science of Russia, Medical Institute

Email: potupchik_tatyana@mail.ru
ORCID iD: 0000-0003-0665-7428
SPIN 代码: 4099-8973

MD

俄罗斯联邦, Krasnoyarsk; Abakan

A. Eremkina

Krasnoyarsk Regional Hospital No. 2, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru
ORCID iD: 0009-0007-1133-6852
SPIN 代码: 9180-1542
俄罗斯联邦, Krasnoyarsk

М. Khabibulina

Ural State Medical University, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru
ORCID iD: 0000-0002-3240-1357
SPIN 代码: 3456-9089

Candidate of Medical Sciences

俄罗斯联邦, Yekaterinburg

M. Shamilov

Ural State Medical University, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru
ORCID iD: 0009-0009-0197-8354
俄罗斯联邦, Yekaterinburg

参考

  1. Stovner L.J., Hagen K., Linde M. et al. The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates. J Headache Pain. 2022; 23 (1): 34. doi: 10.1186/s10194-022-01402-2
  2. Nieswand V., Richter M., Gossrau G. Epidemiology of headache in children and adolescents – another type of pandemia. Curr Pain Headache Rep. 2020; 24 (10): 62. doi: 10.1007/s11916-020-00892-6
  3. Шнайдер Н.А., Кондратьев, А.В., Шульмин, А.В. Эпидемиология головных болей Современные проблемы науки и образования. 2015; 6: 23 [Schneider N.A., Kondratiev, A.V., Shulmin, A.V. Epidemiology of headaches. Modern problems of science and education. 2015;6: 23 (in Russ.)].
  4. Эверт Л.С., Терещенко С.Ю., Зайцева О.И. и др. Психосоматическая коморбидность у подростков Красноярска с различными видами онлайн-поведения. Профилактическая медицина. 2020; 23 (2): 78–84 [Evert L.S., Tereshchenko S.Yu., Zaitseva O.I. et al. Psychosomatic comorbidity in Krasnoyarsk adolescents with various types of online behavior. Preventive medicine. 2020; 23 (2): 78–84 (in Russ.)]. doi: 10.17116/profmed20202302178
  5. Эверт Л.С., Костюченко Ю.Р., Серен-оол С.С. Взаимосвязь головных болей с онлайн-поведением подростков и молодежи Республики Тыва. Новые исследования Тувы. 2024; 3: 6–26 [Evert L.S., Kostyuchenko Yu.R., Seren-ool S.S. The relationship of headaches with online behavior of adolescents and youth of the Republic of Tyva. New studies of Tuva. 2024; 3: 6–26 (in Russ.)]. doi: 10.25178/nit.2024.3.1
  6. Jiménez-Jiménez F.J., Alonso-Navarro H., Garcia-Martin E. et al. Oxidative Stress and Migraine. Mol Neurobiol. 2024; 61: 8344–60. doi: 10.1007/s12035-024-04114-7
  7. Федин А.И. Окислительный стресс в патогенезе хронической головной боли. Журнал неврологии и психиатрии им. С.С. Корсакова. 2024; 124 (10): 35–40 [Fedin A.I. Oxidative stress in the pathogenesis of chronic headache. S.S. Korsakov Journal of Neurology and Psychiatry. 2024; 124 (10): 35–40 (in Russ.)]. doi: 10.17116/jnevro202412410135
  8. Gökçe Çokal B., Aytaç B., Durak Z.E. et al. Serum oxidant and antioxidant status of patients with chronic tension-type headache: possible effects of medical treatment. Neurol Sci. 2015; 36 (10): 1771–5. doi: 10.1007/s10072-015-2240-z
  9. Borkum J.M. Oxidative stress in tension-type headache: a systematic review. J Headache Pain. 2016; 17 (1): 1–8. doi: 10.1186/s10194-016-0606-0
  10. Wang Y., Wang Y., Yue G. et al. Energy metabolism disturbance in migraine: From a mitochondrial point of view. Front physiol. 2023; 14: 1133528. doi: 10.3389/fphys.2023.1133528
  11. Talaie A., Jafary H., Faraji F. et al. The Serum Oxidative Stress Biomarkers and Selenium Levels in a Group of Migraine Patients Compared with Healthy Controls: a Case-Control Study. Biol Trace Elem Res. 2022; 200 (10): 4250–5. doi: 10.1007/s12011-021-03024-2
  12. Vurucu S., Karaoglu A., Paksu M.S. et al. Relationship between oxidative stress and chronic daily headache in children. Hum Еxp Toxicol. 2013; 32 (2): 113–9. doi: 10.1177/0960327112459204
  13. Affaitati, G., Costantini, R., Fiordaliso, M. et al. Pain from Internal Organs and Headache: The Challenge of Comorbidity. Diagnostics (Basel). 2024; 14 (16): 1750. doi: 10.3390/diagnostics14161750
  14. Смирнова О.В., Гончарова Н.С. Характеристика процессов липопероксидации и факторов системы антиоксидантной защиты при хроническом рините. Вестник оториноларингологии. 2024; 89 (1): 16–20 [Smirnova O.V., Goncharova N.S. Characteristics of lipoperoxidation processes and antioxidant protection system factors in chronic rhinitis. Bulletin of otorhinolaryngology. 2024; 89 (1): 16–20 (in Russ.)]. doi: 10.17116/otorino20248901116
  15. Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ «STATISTICA». М.: Медиа Сфера, 2002 [Rebrova O.Y. Statistical analysis of medical data. Application of the STATISTICA software package. Moscow: Media Sphere, 2002 (in Russ.)].
  16. Шахмарданова С.А., Гулевская О.Н., Селецкая В.В. и др. Антиоксиданты: классификация, фармакотерапевтические свойства, использование в практической медицине. Журнал фундаментальной медицины и биологии. 2016; 3: 4–15 [Shakhmardanova S.A., Gulevskaya O.N., Seletskaya V.V. et al. Antioxidants: classification, pharmacotherapeutic properties, use in practical medicine. Journal of Fundamental Medicine and Biology. 2016; 3: 4–15 (in Russ.)].
  17. Белоусова М.А., Корсакова Е.А., Городецкая Е.А. и др. Новые антиоксиданты как нейропротекторы при ишемических повреждениях головного мозга и нейродегенеративных заболеваниях. Экспериментальная и клиническая фармакология. 2014; 77 (11): 36–44 [Belousova M.A., Korsakova E.A., Gorodetskaya E.A. and others. New antioxidants as neuroprotectors in ischemic brain damage and neurodegenerative diseases. Experimental and clinical pharmacology. 2014; 77 (11): 36–44 (in Russ.)].
  18. Государственный реестр лекарственных средств. [The State Register of Medicines (in Russ.)]. URL: https://grls.minzdrav.gov.ru/
  19. Dong Y.S., Wang J.L., Fend D.Y. et al. Protective Effect of Quercetin against Oxidative Stress and Brain Edema in an Experimental Rat Model of Subarachnoid Hemorrhage. Int J Med Sci. 2014; 11 (3): 282–90. doi: 10.7150/ijms.7634
  20. Дедов Д.В. Дигидрокверцетин: фармакологические свойства, возможность применения препарата в клинической практике. Врач. 2022; 33 (10): 78–80 [Dedov D. Dihydroquercetin: pharmacological properties, possibility of using the drug in clinical practice. Vrach. 2022; 33 (10): 78–80 (in Russ.)]. doi: 10.29296/25877305-2022-10-16
  21. Катасонов А.Б. Дигидрокверцетин как системный нейропротектор для профилактики и лечения β-амилоид-ассоциированных заболеваний головного мозга. Журнал неврологии и психиатрии им. С.С. Корсакова. 2023; 123 (7):136–42 [Katasonov A.B. Dihydroquercetin as a systemic neuroprotector for the prevention and treatment of β-amyloid-associated brain diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2023; 123 (7): 136–42 (in Russ.)]. doi: 10.17116/jnevro2023123071136
  22. Sunil C., Xu B. An insight into the health-promoting effects of taxifolin (dihydroquercetin). Phytochemistry. 2019; 166: 112066. doi: 10.1016/j.phytochem.2019.112066
  23. Belosludtseva N.V., Uryupina T.A., Pavlik L.L. et al. Structural and functional alterations in heart mitochondria in a rat model of isoprenaline-induced myocardial injury and their correction with water-soluble Taxifolin. Int J Mol Sci. 2024; 25 (21): 11596. doi: 10.3390/ijms252111596
  24. Усольцева О.Н., Оленников Д.Н., Потупчик Т.В. Оценка качества и биологической активности БиоДигидрокверцетина. Фармация. 2022; 71 (8): 5–14 [Usoltseva O.N., Olennikov D.N., Potupchik T.V. Assessment of the quality and biological activity of Bio-Dihydroquercetin. Pharmacy. 2022; 71 (8): 5–14 (in Russ.)]. doi: 10.29296/25419218-2022-08-01
  25. Усольцева О.Н. Профилактика ускоренного старения и «болезней цивилизации» с помощью природных геропротекторов БиоЧага и БиоДигидрокверцетин. Медицинская сестра. 2022; 24 (3): 43–8 [Usoltseva O.N. Prevention of accelerated aging and «diseases of civilization» with the help of natural geroprotectors BioChaga and BioDihydroquercetin. Meditsinskaya sestra. 2022; 24 (3): 43–8 (in Russ.)]. doi: 10.29296/25879979-2022-03-07
  26. Усольцева О.Н., Оленников Д.Н., Потупчик Т.В. и др. Гриб березовый (чага): характеристика химического состава, биологической активности и продуктов переработки. Фармация. 2023; 72 (4): 58–64 [Usoltseva O.N., Olennikov D.N., Potupchik T.V. et al. Birch mushroom (chaga): characteristics of the chemical composition, biological activity and processed products. Farmatsiya. 2023; 72 (4): 58–64 (in Russ.)]. DOI: 10/29296/25419218-2023-04-08
  27. Потупчик Т.В., Веселова О.Ф., Эверт Л.С. и др. Спектр фармакологических эффектов глицина. Врач. 2015; 12: 14–7 [Potupchik T.V., Veselova O.F., Evert L.S. et al. A spectrum of pharmacological effects of glycine. Vrach. 2015; 12: 14–7 (in Russ.)].
  28. Потупчик Т.В., Эверт Л.С., Веселова О.Ф. и др. Профилактика и коррекция нарушений адаптационно-приспособительных процессов у детей. Медицинская сестра. 2016; 3: 54–5 [Potupchik T.V., Evert L.S., Veselova O.F. et al. Prevention and correction of violations of adaptive processes in children. Meditsinskaya sestra. 2016; 3: 54–5 (in Russ.)].
  29. Ших Е.В., Махова А.А. Роль аскорбиновой кислоты и токоферола в профилактике и лечении заболеваний с точки зрения доказательной медицины. Терапевтический архив. 2015; 4: 98–102 [Shikh E.V., Makhova A.A. The role of ascorbic acid and tocopherol in the prevention and treatment of diseases from the point of view of evidence-based medicine. Therapeutic Archive. 2015; 4: 98–102 (in Russ.)]. doi: 10.17116/terarkh201587498-102
  30. Бочанова Е.Н., Гацких И.В., Потупчик Т.В. и др. Сравнительный анализ поливитаминов для детей. Вопросы биологической, медицинской и фармацевтической химии. 2020; 23 (11): 10–5 [Bochanova E.N., Gatskikh I.V., Potupchik T.V. et al. Comparative analysis of multivitamins for children. Problems of biological, medical and pharmaceutical chemistry. 2020; 23 (11): 10–5 (in Russ.)]. doi: 10.29296/25877313-2020-11-02
  31. Окладникова Е.В., Потупчик Т.В., Эверт Л.С. и др. Особенности метаболизма и спектра действия селена, возможности применения селенсодержащих пищевых добавок в условиях пандемии SARS-COV-2. Вопросы биологической, медицинской и фармацевтической химии. 2022; 25 (3): 23–33 [Okladnikova E.V., Potupchik T.V., Evert L.S. et al. Features of the metabolism and spectrum of action of selenium, the possibility of using selenium-containing food additives in the context of the SARS-COV-2 pandemic. Problems of biological, medical and pharmaceutical chemistry. 2022; 25 (3): 23–33 (in Russ.)]. doi: 10.29296/25877313-2022-03-04
  32. Шовдра С.В. Опыт применения селеносодержащего препарата в педиатрической практике. Международный научно-исследовательский журнал. 2015; 6 (37) [Shovdra S.V. Experience of using a selenium-containing drug in pediatric practice. International Scientific Research Journal. 2015; 6 (37). (in Russ.)].
  33. Щулькин А.В. Современные представления об антигипоксическом и антиоксидантном эффектах мексидола. Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски. 2018; 118 (12–2): 87–93 [Shchulkin A.V. A modern concept of antihypoxic and antioxidant effects of mexidol. S.S. Korsakov Journal of Neurology and Psychiatry. 2018; 118 (12–2): 87–93 (in Russ.)]. doi: 10.17116/jnevro201811812287
  34. Заваденко Н.Н., Суворинова Н.Ю., Заваденко А.Н. Возможности применения Мексидола в нейропедиатрии. Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски. 2023; 123 (9–2): 43–50 [Zavadenko N.N., Suvorinova N.Yu., Zavadenko A.N. The possibilities of Mexidol usage in neuropediatrics. S.S. Korsakov Journal of Neurology and Psychiatry. 2023; 123 (9–2): 43–50 (in Russ.)]. doi: 10.17116/jnevro202312309243

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2. Fig. 1. Distribution of adolescents in the compared groups by the level of malondialdehyde (MDA) in blood plasma

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3. Fig. 2. Distribution of adolescents in the compared groups by the level of MDA in erythrocytes

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4. Fig. 3. Distribution of adolescents in the compared groups by the level of superoxide dismutase (SOD) in in blood plasma

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5. Fig. 4. Distribution of adolescents in the compared groups by the level of SOD in erythrocytes

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