Role of human papillomavirus genotype in the development of epithelial dysplasias and cancer in situ o) the cervix uteri in the Republic of Belarus

Objective: to reveal the dominant genotypes of high cancer risk human papillomaviruses (HCR-HPV) and to determine their association with epithelial dysplasias and cancer in situ of the cervix uteri in the Republic of Belarus. Setting: Gomel State Medical University. Design: a prospective study. Subjects: 97 patients aged 18 to 55 years who had abnormalities of the cervix uteri: stratified squamatous epithelial koilocytosis, first-to-third-degree epithelial dysplasias (CIN I-III), cancer in situ (Ca in situ), and microinvasive carcinoma (FIGO Ia1 stage). Methods: simple and extended colposcopy, morphological study, polymerase chain reaction. Results: 86 (88.6%) out of the 97 patients, were found to have HCR-HPV DNA and 11 (11.4%) were HCR-HPV negative. In 31 (40.8%) cases, epithelial dysplasias and cancer in situ of the cervix uteri were associated with both HPV type 16 as monoinfection and other HCR-HPV types. HPV-33 and HPV-31 rank second and third in occurrence, amounting to 22.4 and 14.5%, respectively. HPV-18 that fills the second place in occurrence in precancer and cancer of the cen'ix uteri in many countries has ranked eighth in our study and accounted for 6.6%. Conclusion: differences have been established in the prevalence of HPV genotypes in the development of epithelial dysplasias and cancer of the cervix uteri in the Republic of Belarus us compared with North America and Western European countries. This information gives grounds to continue studies in this area, so that during population-based studies investigators can obtain reliable values of dominant HPV genotypes in the development of epithelial dysplasias and cancer of the cervix uteri and develop an optimally adapted virus panel for the designing a prophylactic vaccine that will satisfy the specific features of the epidemiology of genital HPV infection in the Republic of Belarus.