Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media246493ArticlesСтатьиResearch ArticleROLE OF ANGIOGENESIS IN THE PATHOGENESIS OF ENDOMETRIOSISРОЛЬ АНГИОГЕНЕЗА В ПАТОГЕНЕЗЕ ЭНДОМЕТРИОЗАKUZNETSOVAI. VКУЗНЕЦОВАИрина Всеволодовна

д-р мед. наук, проф. каф. акушерства и гинекологии

E-maihms_smith@Nst.ruRussian Medical Academy of Postgraduate EducationГОУ ВПО Российская медицинская академия последипломного образования150520115NO5 (2011)№5 (2011)162217022023Copyright ©; 2011, Bionika MediaCopyright ©; 2011, ООО «Бионика Медиа»2011Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/246493

The paper deals with the present views of the pathogenetic mechanisms of occurrence of endometriosis. It describes the role of angiogenesis in the development of endometriosis, the basic mechanisms of the formation of the vascular bed, and the factors influencing the angiogenic process in endometriosis (vascular endothelial growth factors, cytokines, transforming growth factor-ß, Smads). Data are given on the effect of gonadotropin-releasing hormone (GnRH) agonists on tissue growth processes via a few mechanisms, among which there is angiogenesis regulation. The pooled findings serve as evidence that GnRH agonists have a direct effect on endometrioid tissue, by simulating the expression of various growth factors involved in the angiogenic process.

В статье освещены современные представления о патогенетических механизмах возникновения эндометриоза. Описаны роль ангиогенеза в развитии эндометриоза, основные механизмы формирования сосудистого русла, факторы, влияющие на процесс ангиогенеза при эндометриозе (сосудистые эндотелиальные факторы роста, цитокины, трансформирующий фактор роста ß, Smads). Представлены данные о воздействии агонистов гонадотропин-рилизинг-гормона (ГнРГ) на процессы роста тканей посредством нескольких механизмов, среди которых — регуляция ангиогенеза. Совокупность полученных данных служит доказательством того, что агонисты ГнРГ оказывают прямое воздействие на эндометриоидную ткань, моделируя экспрессию различных ростовых факторов, вовлеченных в процесс ангиогенеза.

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