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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство и гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0300-9092</issn><issn publication-format="electronic">2412-5679</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">246596</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">COMBINATION HORMONAL CONTRACEPTION: QUESTIONS AND ANSWERS</article-title><trans-title-group xml:lang="ru"><trans-title>КОМБИНИРОВАННАЯ ГОРМОНАЛЬНАЯ КОНРАЦЕПЦИЯ В ВОПРОСАХ И ОТВЕТАХ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>BOSTANDZHYAN</surname><given-names>L. L</given-names></name><name xml:lang="ru"><surname>БОСТАНДЖЯН</surname><given-names>Лана Лаврентьевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, науч. сотр. научно-поликлинического отд-ния</p></bio><email>l_bostanjian@oparina4.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>PRILEPSKAYA</surname><given-names>V. N</given-names></name><name xml:lang="ru"><surname>ПРИЛЕПСКАЯ</surname><given-names>В. Н</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia</institution></aff><aff><institution xml:lang="ru">ФГУ Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздравсоцразвития России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-05-15" publication-format="electronic"><day>15</day><month>05</month><year>2011</year></pub-date><issue>5</issue><issue-title xml:lang="en">NO5 (2011)</issue-title><issue-title xml:lang="ru">№5 (2011)</issue-title><fpage>129</fpage><lpage>133</lpage><history><date date-type="received" iso-8601-date="2023-02-17"><day>17</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2011, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2011, ООО «Бионика Медиа»</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/0300-9092/article/view/246596">https://journals.eco-vector.com/0300-9092/article/view/246596</self-uri><abstract xml:lang="en"><p>The review of world literature has shown that there are currently unavailable scientifically founded data suggesting that it is necessary to discontinue the use of combined oral contraceptives (COC) every several years. On the contrary, the present-day specialists’ viewpoint that it is possible and necessary to use COC without interruption so long as there is a need for contraception is quite valid.</p></abstract><trans-abstract xml:lang="ru"><p>Обзор мировой литературы показал, что в настоящее время нет никаких научно обоснованных данных, указывающих на необходимость прерывания приема комбинированных оральных контрацептивов (КОК) каждые несколько лет. Напротив, вполне правомерна точка зрения современных специалистов о возможности и необходимости приема КОК без перерывов так долго, пока существует потребность в контрацепции.</p></trans-abstract><kwd-group xml:lang="en"><kwd>interruptions in COC use</kwd><kwd>noncontraceptive effects of COC</kwd><kwd>risk for cancer</kwd><kwd>venous thrombophilia</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>перерывы в приеме КОК</kwd><kwd>неконтрацептивные эффекты КОК</kwd><kwd>риск развития онкологических заболеваний</kwd><kwd>венозная тромбоэмболия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Серов В.Н., Прилепская В.Н., Овсянникова Т.В. Гинекологическая эндокринология. — М., 2006. — C. 252—284.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Barnhart K.T., Schreiber C.A. Return to fertility following discontinuation of oral contraceptives // Fertil End Steril. — 2009. — Vol. 91, № 3. — P. 659—663.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Bianchi-Demicheli F., Ludicke F., Campana A. Premenstrual dysphoric disorder: approach and treatment// Gynecol. Obstet. Fertil. — 2003. — Vol. 31, № 1. — P. 49—54.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Braendle W., Kuhl H., Mueck A. et al. Does hormonal contraception increase the risk for tumors? // Ther. Umsch. — 2009. — Vol. 66, № 2. — P. 129—135.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Burkman R.T., Collins J.A., Shulman L.P. et al. Current perspectives on oral contraceptive use// Am. J. Obstet. Gynecol. — 2001. — Vol. 185. — P. 4—12.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Dinger J.C., Heinemann L.A., Kühl-Habich D. The safety of a drospirenon-containig oral contraceptive: final results from the European Active Surveillance study on oral contraceptives based on 142, 475 women-years of observation// Contraception. — 2007. — Vol. 75, № 5. — P. 344—354.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Farrow A., Hull M.G.R., Northstone K. et al. Prolonged use of oral contraception before a planned pregnancy is associated with a decreased risk of delayed conception // Hum. Reprod. — 2002. — Vol. 17, № 10. — P. 2754—2761.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Fernandez E., La Vecchia C., Balducci A. et al. Oral contraceptives and colorectal cancer risk: a meta-analysis// Br. J. Cancer. — 2001. — Vol. 84, № 5. — P. 722—727.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Folger S.G., Marchbanks P.A., McDonald J.A. et al. Risk of breast cancer associated with short-term use of oral contraceptives// Cancer Causes Control. — 2007. — Vol. 18. — P. 189—198.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Glasier A., Shields W.C. Can we improve contraceptive use?// Contraсeption. — 2006. — Vol. 73, № 1. — P. 1—3.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Huber L.R., Hogue C.J., Drews C., et al. Contraceptive use and discontinuation : findings from the contraceptive history, initiation, and choice study//Am. J. Obstet. Gynecol. — 2006. — Vol.194, № 5. — P. 1290—1295.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Hunter D.J., Colditz G.A., Hankinson S.E. et al. Oral contraceptive use and breast cancer: a prospective study of young women// Cancer Epidemiol. Biomarkers Prev. — 2010. — Vol. 19, № 10. — Р. 2496—2502.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Khader Y.S., Rice J., John L. et al. Oral contraceptives use and the risk of myocardial infarction: a meta-analysis// Contraception. — 2003. — Vol. 68. — P. 11—17.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Kuohung W., Borgatta L., Stubblefield Ph. Low-dose oral contraceptives and bone mineral density: An evidence-based analysis// Contraception. — 2000. — Vol. 61, № 2. — P. 77—82.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Lech M.M., Ostrowska L. Risk of cancer development in relation to oral contraception// Eur. J. Contrasept. Reprod. Hlth Care. — 2006. — Vol. 11, № 3. — P. 162—168.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Lidegaard O., Lokkegaard E., Svendsen A.L. et al. Hormonal contraception and risk of venous thromboembolism: national follow-up study// Br. Med. J. — 2009. — Vol. 339. — Р. 2890.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Lloyd T., Taylor D.S., Lin H.M. et al. Oral contraceptive use by teenage women does not affect peak bone mass: a longitudinal study//Fertil and Steril. — 2000. — Vol. 74. — P. 734—738.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Marchbanks P.A., McDonald J.A., Wilson H.G. et al. Oral contraceptives and the risk of the breast cancer// N. Engl. J. Med. — 2002. — Vol. 346. — P. 2025—2032.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Moreau C., Cleland K., Trussell J. Contraceptive discontinuation attributed to method dissatisfaction in the United States// Contraception. — 2007. — Vol. 76, № 4. — P. 267—272.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Mueck A.O., Seeger H., Rabe T. Hormonal contraception and risk of endometrial cancer: a systematic review// Endocrinol. Relat. Cancer. - 2010. - Vol. 23, № 17. — Р. 263—271.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Oelkers W. Antimineralcorticoid activity of a novel oral contraceptive containing drospirenon, a unique progestogen resembling natural progesterone//Eur. J. Contracept. Reprod. Hlth Care. — 2002. — Vol. 7, suppl. 3. — P. 19—26.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Pearlstein T.B., Bachmann G.A., Zacur H.A. et al. Treatment of premenstrual dysphoric disorder with a new drospirenone-containing oral contraceptive formulation// Contraception. — 2005. — Vol. 72. — P. 414—421.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Pymar H.C., Creinin M.D. The risks of oral contraceptive pills// Semin. Reprod. Med. — 2001. — Vol. 19. — P. 305312.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Reed S.D., Scholes A.Z., LaCroix L.E. et al. Longitudinal changes in bone density in relation to oral contraceptive use// Contraception. — 2003. — Vol. 68. — P. 177-182.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Spitzer W.O., Faith J.M., Macrae K.D. Myocardial infarction and third generation oral contraceptives: aggregation of recent studies// Hum. Reprod. — 2002. — Vol. 17. — P. 2307—2314.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Vaughan B., Trussel J., Kost K. et al. Discontinuation and resumption of contraceptive use: results from the 2002 Natiional Survey of family Growth // Contraception. - 2008. — Vol. 78, № 4. — P. 271—283.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Waesthoff C.L., Heartwell S., Edwards S. et al. Oral contraceptive discontinuation: do side effects matter?// Am. J. Obstet. Gynecol. - 2007. — Vol. 196, № 4. — Р. 412.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Yonkers K.A., Brown C., Pearlstein T.B. et al. Efficacy of a new low-dose oral contraceptive with drospirenon in premenstrual dysphoric disorder// Obstet. Gynecol. — 2005. — Vol. 106, № 3. — P. 492—501.</mixed-citation></ref></ref-list></back></article>
