Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media246888ArticlesСтатьиReview ArticleRELATIONSHIP OF PATHOZOOSPERMIA AND CHROMOSOME ANEUPLOIDY IN THE SPERM AND EMBRYOS IN ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMSВЗАИМОСВЯЗЬ ПАТОЗООСПЕРМИИ И АНЕУПЛОИДИИ ХРОМОСОМ В СПЕРМАТОЗОИДАХ И ЭМБРИОНАХ В ПРОГРАММАХ ВСПОМОГАТЕЛЬНЫХ РЕПРОДУКТИВНЫХ ТЕХНОЛОГИЙSOKURS. AСОКУРСветлана Александровна

аспирант лаборатории репродуктивной генетики

sokursv@yandex.ruDOLGUSHINAN. VДОЛГУШИНАНаталия Витальевна

доктор медицинских наук, руководитель Службы научно-организационного обеспечения

n_dolgushina@oparina4.ruGLINKINAZH. IГЛИНКИНАЖанна Ивановна

доктор биологических наук, заведующая лаборатории репродуктивной генетики

z_glinkina@oparina4.ruAcademician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава РоссииOOO "Petrovskie Vorota" Maternity and Reproductive Medicine CenterООО Центр материнства и репродуктивной медицины «Петровские Ворота»150320133NO3 (2013)№3 (2013)101317022023Copyright ©; 2013, Bionika MediaCopyright ©; 2013, ООО «Бионика Медиа»2013Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/246888

This review estimates the incidence of aneuploidy in the sperm nuclei and embryos of males with reproductive dysfunction and fertility. It gives the data of studies evaluating the impact of different types of pathozoospermia on the level of chromosome aneuploidy in the sperm nuclei. Chromosome aneuploidy in the sperm was assessed for its influence on that in the embryos. The outcomes of assisted reproductive technology programs were analyzed in the married couples in which the husbands had elevated sperm chromosome aneuploidy. The possibilities of using preimplantation genetic diagnosis as a measure to prevent the birth of babies with genetic pathology in this category of patients are considered.

В обзоре приведена сравнительная оценка распространенности анеуплоидии в ядрах сперматозоидов и эмбрионов у супружеских пар с нарушением и сохранением репродуктивной функции у мужчин. Приведены данные исследований, в которых изучалась связь различных видов патозооспермии и анеуплоидии хромосом в ядрах сперматозоидов. Оценено влияние анеуплоидии хромосом в ядрах сперматозоидов на уровень анеуплоидии хромосом эмбрионов. Проведен анализ исходов программ вспомогательных репродуктивных технологий у супружеских пар c повышенным уровнем анеуплоидии хромосом в ядрах сперматозоидов у мужчин. Рассмотрены возможности применения преимплантационной генетической диагностики как меры профилактики рождения детей с генетической патологией у данной категории пациентов.

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