Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media246891ArticlesСтатьиReview ArticlePOSSIBILITIES FOR MEDICAL PREVENTION OF OVARIAN HYPERSTIMULATION SYNDROMEВОЗМОЖНОСТИ МЕДИКАМЕНТОЗНОЙ ПРОФИЛАКТИКИ СИНДРОМА ГИПЕРСТИМУЛЯЦИИ ЯИЧНИКОВFETISOVAS. VФЕТИСОВАСветлана Валентиновна

аспирант отделения восстановления и сохранения репродуктивной функции

svfetisova@mail.ruKORNEEVAI. EКОРНЕЕВАИрина Евгеньевна

ведущий научный сотрудник, доктор медицинских наук, врач высшей категории отделения сохранения и восстановления репродуктивной функции

irina.korneeva@inbox.ruAcademician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaФГБУ Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России150320133NO3 (2013)№3 (2013)142017022023Copyright ©; 2013, Bionika MediaCopyright ©; 2013, ООО «Бионика Медиа»2013Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/246891

This review presents an update on the role of vascular endothelial (VE) growth factor (VEGF) in the pathogenesis of ovarian hyperstimulation syndrome (OHSS). The paper shows the pathophysiological bases for the development of this iatrogenic complication: hypovolemia, hemoconcentration, dysproteinemia. VEGF receptor-1 (Flt-1) and VEGF receptor-2 (KDR), VE cadherins are considered to be involved in the development of OHSS. Particular attention is given to the effect of dopamine D2-receptor agonists on the basic pathophysiological mechanism of OHSS - vascular permeability. Data on the efficacy of this group of agents in the prevention of this complication are given. It is emphasized that the use of dopamine D2-receptor agonists needs further investigation in order to define their ultimate place in the prevention of OHSS.

В обзоре представлены современные данные о роли сосудистого эндотелиального фактора роста (СЭФР) в патогенезе синдрома гиперстимуляции яичников (СГЯ). В статье отражены патофизиологические основы формирования этого ятрогенного осложнения: гиповолемии, гемоконцентрации, диспротеинемии. Рассмотрено участие рецепторов СЭФР первого (Flt-1) и второго (KDR) типов, сосудистых кадгеринов (VE) в развитии СГЯ. Особое внимание обращено на влияние агонистов D2-допаминовых рецепторов на основной патофизиологический механизм синдрома гиперстимуляции яичников - сосудистую проницаемость. Представлены данные об эффективности данной группы препаратов в профилактике этого осложнения. Подчеркнута необходимость дальнейшего изучения применения агонистов D2-допаминовых рецепторов для определения окончательного места в профилактике СГЯ.

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