Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media247203ArticlesСтатьиResearch ArticleMitochondrial dysfunction as one of the mechanisms of impaired reproductive function in obesityДисфункция митохондрий как один из механизмов нарушения репродуктивной функции при ожиренииGorshinovaV. KГоршиноваВиктория Константиновна

Post-graduate student, Department of assistive technologies in infertility treatment

аспирант отделения вспомогательных технологий в лечении бесплодия

chiasma@mail.ruTsvirkunD. VЦвиркунДарья Викторовна

PhD, Senior researcher, Mitochondrial medicine group

к.б.н., с.н.с. лаборатории митохондриальной медицины

darunyat@gmail.comDesyatkovaN. VДесятковаНина Владимировна

Post-graduate student, Department of assistive technologies in infertility treatment

аспирант отделения вспомогательных технологий в лечении бесплодия

VysokikhM. YuВысокихМихаил Юрьевич

PhD, Head of mitochondrial medicine research group; Head of aging molecular mechanisms group

к.б.н., зав. лабораторией митохондриальной медицины; зав. лабораторией молекулярных механизмов старения

m_vysokikh@oparina4.ruSmolnikovaV. YuСмольниковаВероника Юрьевна

PhD, Leading researcher, Department of assistive technologies in infertility treatment

д.м.н., в.н.с. отделения вспомогательных технологий в лечении бесплодия

veronika.smolnikova@mail.ruAcademician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the RussiaФГБУ Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава РоссииA.N. Belozersky Research Institute of Physicochemical Biology, M.V. Lomonosov Moscow State UniversityНИИ Физико-химической биологии им. А.Н. Белозерского, МГУ им. М.В. Ломоносова150720147NO7 (2014)№7 (2014)91317022023Copyright ©; 2014, Bionika MediaCopyright ©; 2014, ООО «Бионика Медиа»2014Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/247203

The review gives data on the role of mitochondrial function in the oocytes and embryos in realizing the reproductive potential in obese women. Many publications have shown the lower therapeutic effectiveness of an in vitro fertilization program in overweight women than in normal weight ones, which is manifested in the reductions of the number of oocytes and the potential of embryos to implantation and further development and which is also accompanied by increased aneuploidy rates. The given data suggest that chronic oxidative stress in overweight women is associated with mitochondrial dysfunction and elevated blood levels of proinflammatory factors. Moreover, induction of chronic inflammation has a negative impact on the quality of oocytes and embryos, leading to impaired implantation and further increased risk of pregnancy termination.

В обзоре представлены данные о роли функционального состояния митохондрий ооцитов и эмбрионов в реализации репродуктивного потенциала у женщин, страдающих ожирением. Во многих работах было показано снижение эффективности лечения в программе экстракорпорального оплодотворения (ЭКО) у женщин с избыточной массой тела по сравнению с женщинами, имеющими нормальный вес, которое выражалось в снижении качества ооцитов и потенциала эмбрионов к имплантации и дальнейшему развитию, а также сопровождалось увеличением частоты анеуплоидий. Представленные данные свидетельствуют о том, что хронический окислительный стресс у женщин с избыточной массой тела сопряжен с дисфункцией митохондрий и повышением содержания в крови провоспалительных факторов. При этом индукция состояния хронического воспаления оказывает негативное влияние на качество ооцитов и эмбрионов, приводя к нарушению имплантации и повышению в дальнейшем риска прерывания беременности.

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