Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media247540ArticlesСтатьиReview ArticleIMPAIRED IMMUNE MECHANISMS DUE TO PERINATAL STRESS: EXPERIMENTAL AND CLINICAL FINDINGSНАРУШЕНИЕ ИММУННЫХ МЕХАНИЗМОВ ЗАЩИТЫ В РЕЗУЛЬТАТЕ ПЕРИНАТАЛЬНОГО СТРЕССА ПО ДАННЫМ ЭКСПЕРИМЕНТАЛЬНОГО И КЛИНИЧЕСКОГО ИССЛЕДОВАНИЙKhudaverdyanAnna DrastamatovnaХудавердянАнна Драстаматовна

MD, PhD, senior lecturer, Department of Obstetrics and Gynecology #2

к.м.н., старший преподаватель, кафедра акушерства и гинекологии № 2

anna.khudaverdyan2@mail.ruTorgomyanAdelina LevanovnaТоргомянАделина Левановна

MD, PhD, senior lecturer, Department of Physiology

к.м.н., старший преподаватель, кафедра физиологии

KhudaverdyanDrastamat NagapetovichХудавердянДрастамат Нагапетович

MD, PhD, professor Head of Physiology department

профессор, зав. кафедрой физиологии

Yerevan State Medical UniversityЕреванский государственный медицинский университет1512201512NO12 (2015)№12 (2015)515618022023Copyright ©; 2015, Bionika MediaCopyright ©; 2015, ООО «Бионика Медиа»2015Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/247540

The stress reaction becomes a nonspecific cause of many pathological conditions in which the impaired immune protection mechanisms are of fundamental importance. Objective. To analyze the data available in the literature on studies of immune disorders due to the prenatal stress experienced.ц Subject and methods. The key words, such stress, glucocorticoids, immunity, adrenals, were used to search for data in international and Russian databases. A total of 39 sources on suitable themes were selected. Results. The mechanisms of adaptive responses are interlinked in a complex manner and may be multidirectional with the possibility of changing from protective to destructive ones. They become a basis for the development of pathological processes that depend on the number, intensity, and duration of stress factors and on the specific features of the body and its predisposition to different pathological processes. Conclusion. Impaired immune protection mechanisms are of prime importance in the development of these complications.

Стрессовая реакция становится неспецифической причиной многочисленных патологических состояний, в которых нарушения иммунных механизмов защиты имеют первостепенное значение. Цель исследования. Анализ литературных данных, посвященных изучению иммунных нарушений, являющихся результатом перенесенного пренатального стресса. Материал и методы. По ключевым словам (стресс, глюкокортикоиды, иммунитет, надпочечники) был произведен поиск в международных и отечественных базах данных. Отобрано 39 источников, подходящих по тематике. Результаты. Механизмы адаптативных реакций взаимосвязаны сложным образом и могут иметь разнонаправленный характер, с возможностью перехода от защитных к разрушительным. Они становятся основой развития патологических процессов, которые зависят от количества, интенсивности и продолжительности стрессогенных факторов, а также особенностей организма, его предрасположенности к различным патологическим процессам. Заключение. В развитии этих осложнений нарушения иммунных механизмов защиты имеют первостепенное значение.

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