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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство и гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0300-9092</issn><issn publication-format="electronic">2412-5679</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">247609</article-id><article-id pub-id-type="doi">10.18565/aig.2016.4.11-15</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Medically induced abortion at 12 to 22 weeks gestation: Indications, methods, and results</article-title><trans-title-group xml:lang="ru"><trans-title>Медикаментозное завершение беременности в сроки от 12 до 22 недель: показания, методы и результаты</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kan</surname><given-names>Natalia E.</given-names></name><name xml:lang="ru"><surname>Кан</surname><given-names>Наталья Енкыновна</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, MD, the head of the obstetric observation department</p></bio><bio xml:lang="ru"><p>д.м.н., зав. акушерским обсервационным отделением</p></bio><email>kan-med@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Baranov</surname><given-names>Igor I.</given-names></name><name xml:lang="ru"><surname>Баранов</surname><given-names>Игорь Иванович</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, MD, the head of the organizational-methodological department</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, зав. организационно-методическим отделом</p></bio><email>i_baranov@oparina4.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dikke</surname><given-names>Galina B.</given-names></name><name xml:lang="ru"><surname>Дикке</surname><given-names>Галина Борисовна</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, MD, professor of obstetrics, gynecology and reproductive medicine faculty of postgraduate education of health professionals</p></bio><bio xml:lang="ru"><p>д.м.н., профессор кафедры акушерства, гинекологии и репродуктивной медицины факультета последипломного образования медицинских работников</p></bio><email>galadikke@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tyutyunnik</surname><given-names>Victor L.</given-names></name><name xml:lang="ru"><surname>Тютюнник</surname><given-names>Виктор Леонидович</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, MD, the head of the obstetric physiological department</p></bio><bio xml:lang="ru"><p>д.м.н., зав. акушерским физиологическим отделением</p></bio><email>tioutiounnik@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ НЦАГиП им. академика В.И. Кулакова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «НЦАГиП им. академика В.И. Кулакова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Peoples' Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО Российский университет дружбы народов</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2016</year></pub-date><issue>4</issue><issue-title xml:lang="en">NO4 (2016)</issue-title><issue-title xml:lang="ru">№4 (2016)</issue-title><fpage>11</fpage><lpage>15</lpage><history><date date-type="received" iso-8601-date="2023-02-18"><day>18</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ООО «Бионика Медиа»</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/0300-9092/article/view/247609">https://journals.eco-vector.com/0300-9092/article/view/247609</self-uri><abstract xml:lang="en"><p>Objective. To give an update on abortion procedures in the second trimester of pregnancy (at 12 to 22 weeks’ gestation). Subject and methods. Available literature sources published in Medline, Pubmed, and other databases were sought. A total of 107 sources dealing with different abortion procedures in the second trimester were found; 20 of them were included in this review. Results. Both surgical (dilatation and evacuation) and medical procedures are recommended to end pregnancy after 12 weeks. Their advantages, high efficiency, and possible complications of the medical procedure using mifepristone and misoprostol over other techniques are shown. Conclusion. The clinical experience of medically induced abortion in late periods (in the second trimester - at 12 to 22 weeks’ gestation) demonstrates that this technique is promising and safe.</p></abstract><trans-abstract xml:lang="ru"><p>Цель исследования. Представить современные данные о методах прерывания беременности во II триместре (от 12 до 22 недель) беременности. Материал и методы. Проведен поиск доступных литературных источников, опубликованных в базе данных Medline, Pubmed и др. Было найдено 107 источников, посвященных различным методам прерывания беременности во II триместре, из которых 20 были включены в данный обзор. Результаты. Для прерывания беременности сроком более 12 недель рекомендуются, как хирургический (дилатация и эвакуация), так и медикаментозный методы. Показаны преимущества, высокая эффективность и возможные осложнения медикаментозного метода с использованием мифепристона и мизопростола по сравнению с другими методиками. Заключение. Клинический опыт медикаментозного прерывания беременности в поздних сроках (II триместр - от 12 до 22 недель) демонстрирует перспективность и безопасность этого метода.</p></trans-abstract><kwd-group xml:lang="en"><kwd>pregnancy termination</kwd><kwd>late pregnancy periods</kwd><kwd>medical abortion</kwd><kwd>mifepristone</kwd><kwd>misoprostol</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>прерывание беременности</kwd><kwd>поздние сроки беременности</kwd><kwd>медикаментозный аборт</kwd><kwd>мифепристон</kwd><kwd>мизопростол</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Основные показатели здоровья матери и ребенка, деятельность службы охраны детства и родовспоможения в Российской Федерации. М.; 2014. [Key indicators of maternal and child health, child welfare service activities and obstetrics in the Russian Federation. M., 201. 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