Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media24761710.18565/aig.2016.4.26-35ArticlesСтатьиResearch ArticleCell metabolic reprogramming as a factor for induction and progression of cervical precancer and cancerМетаболическое репрограммирование клеток как фактор индукции и прогрессии предрака и рака шейки маткиKhlebkovaYulia S.ХлебковаЮлия Сергеевна

postgraduate

аспирант

y_khlebkova@oparina4.ruVysokikhMikhail Yu.ВысокихМихаил Юрьевич

PhD, Head of mitochondrial medicine research group

к.б.н., зав. лабораторией митохондриальной медицины

m_vysokikh@oparina4.ruMezhevitinovaElena A.МежевитиноваЕлена Анатольевна

MD

д.м.н., в.н.с. научно-поликлинического отделения

Mejevitinova@mail.ruVishnyakovaPolina A.ВишняковаПолина Александровна

researcher at the Laboratory of mitochondrial medicine

научный сотрудник лаборатории митохондриальной медицины

p_vishnyakova@oparina4.ruPrilepskayaVera N.ПрилепскаяВера Николаевна

MD, Professor

д.м.н., профессор, зав. поликлиническим отделением, зам. директора по науке

v_prilepskaya@oparina4.ruSukhikhGennady T.СухихГеннадий Тихонович

PhD, MD, professor, academician of RAS, Director

д.м.н., академик РАН, профессор, директор

g_sukhikh@oparina4.ruResearch Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaФГБУ НЦАГиП им. академика В.И. Кулакова Минздрава России150420164NO4 (2016)№4 (2016)263518022023Copyright ©; 2016, Bionika MediaCopyright ©; 2016, ООО «Бионика Медиа»2016Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/247617

Objective. To carry out a systematic analysis of the data available in the modern literature on metabolic reprogramming of tumor cells and to search for clin ical and molecular markers for early diagnosis and prognosis of cervical precancer and cancer. Subject and methods. The review included the data of foreign and Russian papers published in the past 10 years and found in Pubmed on this topic. Results. The cell metabolic reprogramming mechanism and its role in the progression and regression of cervical precancer and cancer were described. The markers for their early diagnosis were identified. Conclusion. There is a need for further investigations of the role of cell metabolic reprogramming and its impact on the induction and progression of cervical precancer and cancer in order to develop early diagnostic techniques and to search for markers determ ining the prognosis of the disease.

Цель исследования. Провести систематический анализ данных, имеющихся в современной литературе, посвященной проблеме метаболического репрограммирования опухолевых клеток, а также провести поиск клинических и молекулярных маркеров для ранней диагностики и прогнозирования прогрессии предрака и рака шейки матки (РШМ). Материал и методы. В обзор включены данные зарубежных и отечественных статей, найденных в Pubmed по данной теме, опубликованных за последние 10 лет. Результаты. Описан механизм метаболического репрограммирования клеток и его роль в прогрессии или регрессии предрака и РШМ. Определены маркеры ранней диагностики. Заключение. Необходимо проведение дальнейших исследований в направлении изучения роли метаболического репрограммирования клеток и его влияния на индукцию и прогрессию предрака и РШМ для разработки методов ранней диагностики, а также поиск маркеров, определяющих прогноз заболевания.

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