Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media24764310.18565/aig.2016.6.46-51ArticlesСтатьиResearch ArticleAssociation of pregnancy outcomes with fetal amino acid metabolism and maternal obesityСвязь исходов беременности с метаболизмом аминокислот у плода и ожирением у материBashmakovaNadezhda V.БашмаковаНадежда Васильевна

MD, professor, Honored Doctor of Russian Federation, Director

д.м.н., профессор, заслуженный врач РФ, директор

dr@niiomm.ruTsyvyanPavel B.ЦывьянПавел Борисович

MD, professor, Head of Department of Normal Physiology, of Ural State Medical University; leading researcher at Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia; senior researcher at Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences.

д.м.н., профессор, зав. кафедрой нормальной физиологии; в.н.с.

pavel.tsyvian@gmail.comPestryaevaLyudmila A.ПестряеваЛюдмила Анатольевна

PhD, Head of Biochemical laboratory

к.б.н., зав. биохимической лабораторией

pestryeval@yandex.ruUral Research Institute of Maternal and Infant Care, Ministry of Health of RussiaГБУ Уральский НИИ ОММ Минздрава РоссииUral State Medical UniversityГБОУ ВПО Уральский ГМУInstitute of Immunology and Physiology, Ural Branch, Russian Academy of SciencesИнститут иммунологии и физиологии УрО РАН150620166NO6 (2016)№6 (2016)465318022023Copyright ©; 2016, Bionika MediaCopyright ©; 2016, ООО «Бионика Медиа»2016Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/247643

Objective. To compare the blood concentrations of essential amino acids in mothers and newborn infants during normal pregnancy (a control group; n = 28) and in two study groups of obese women who had given birth to normal (Group 1; n = 46) and low (Group 2; n = 44) birth weight babies. Material and methods. The concentrations of amino acids were measured using an automatic amino acid T339M analyzer (Czechia); biochemical examinations were made on a Sapphire-400 analyzer (Japan). Results. The mean weight of babies in Group 2 was significantly lower than that of those in the control group and Control 1. Cholesterol and lipoproteins were considerably elevated in the obese women, particularly in Group 2. The concentrations of the majority of amino acids and the fetal-maternal concentration gradients were lower in obese women, especially in Group 2. Conclusion. There was a substantial reduction in the amino acid transport-and-concentration function of the placenta in obese women, particularly in those who had given birth to low-birth weight infants, which agrees with the fetal programmed theory of diseases.

Цель исследования. Сравнить концентрации основных аминокислот в крови матерей и новорожденных детей при нормальной беременности - контрольная группа (n=28), и в двух основных группах женщин с ожирением, родившихся с нормальным весом (1-я группа, n=46) и с малым весом (2-я группа, n=44). Материал и методы. Оценка концентраций аминокислот проведена автоматическим анализатором ААА-Т339М (Чехия), биохимические исследования - Sapphire-400 (Япония). Результаты. Средний вес детей 2-й группы был значимо ниже, чем детей контрольной и 1-й групп. Холестерин и липопротеины были значимо повышены у женщин с ожирением, особенно во 2-й группе. Концентрации большинства аминокислот и плодово-материнские градиенты их концентраций были снижены у женщин с ожирением, особенно во 2-й группе. Заключение. Показано значительное снижение аминокислотной транспортно-концентрационной функции плаценты у женщин с ожирением, в особенности у тех, кто сам родился с низкой массой тела, что согласуется с теорией внутриутробно программируемых заболеваний.

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