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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство и гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0300-9092</issn><issn publication-format="electronic">2412-5679</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">247682</article-id><article-id pub-id-type="doi">10.18565/aig.2016.4.107-111</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Evidence-based medicine and a model for an algorithm to choose the best hormonal contraceptive</article-title><trans-title-group xml:lang="ru"><trans-title>Доказательная медицина и модель алгоритма выбора гормонального контрацептивного препарата</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rukhlyada</surname><given-names>N. N</given-names></name><name xml:lang="ru"><surname>Рухляда</surname><given-names>Николай Николаевич</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, PhD, professor, head of the gynecology clinic</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, руководитель клиники гинекологии</p></bio><email>nickolasr@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.I. Dzhanelidze Saint Petersburg Research Institute of Emergence Care</institution></aff><aff><institution xml:lang="ru">ГБУЗ Санкт-Петербургский НИИ Скорой помощи им. И.И. Джанелидзе</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2016</year></pub-date><issue>4</issue><issue-title xml:lang="en">NO4 (2016)</issue-title><issue-title xml:lang="ru">№4 (2016)</issue-title><fpage>107</fpage><lpage>111</lpage><history><date date-type="received" iso-8601-date="2023-02-18"><day>18</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ООО «Бионика Медиа»</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/0300-9092/article/view/247682">https://journals.eco-vector.com/0300-9092/article/view/247682</self-uri><abstract xml:lang="en"><p>Objective. To carry out a systematic analysis of the data that may predict the tolerability of various hormonal contraceptives in order to elaborate an algorithm to choose the best hormonal contraceptive. Material and methods. A meta-analysis of literature data on the tolerability of hormonal contraceptives was made. Results. A computerized MyContraception algorithm to choose hormonal contraception and a specific contraceptive was elaborated using a mathematical model of multivariate analysis of their tolerability, acceptability, and side-effectprofile. Conclusion. It is necessary to accumulate a knowledge base using the recipient-application feedback that will be able to dynamically improve the mathematical algorithm with consideration for information accumulation, as well as the possibility of complementing novel hormone-containing contraceptives to the knowledge base.</p></abstract><trans-abstract xml:lang="ru"><p>Цель исследования. Провести систематический анализ данных, позволяющих прогнозировать переносимость различных гормональных контрацептивных препаратов, с целью создания алгоритма выбора гормонального контрацептивного препарата. Материал и методы. Метанализ литературных данных по переносимости гормональных контрацептивных препаратов. Результаты. Создание компьютеризированного алгоритма MyContraception выбора метода гормональной контрацепции, а также конкретного контрацептивного препарата, основанного на математической модели многофакторного анализа переносимости, приемлемости и профиля побочных эффектов. Заключение. Необходимо накопление базы знаний на основе обратной связи «приложение-реципиент», которая позволит динамически усовершенствовать математический алгоритм с учетом накопления информации и возможности добавления в базу знаний новый контрацептивных гормонсодержащих препаратов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>contraception</kwd><kwd>contraceptives</kwd><kwd>algorithm</kwd><kwd>tolerability</kwd><kwd>contraindications</kwd><kwd>criteria</kwd><kwd>estrogens</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>контрацепция</kwd><kwd>контрацептивы</kwd><kwd>алгоритм</kwd><kwd>переносимость</kwd><kwd>противопоказания</kwd><kwd>критерии</kwd><kwd>эстрогены</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Liao P.V., Dollin J. Half a century of the oral contraceptive pill: historical review and view to the future. Can. Fam. 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