Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media24789910.18565/aig.2017.3.34-40ArticlesСтатьиResearch ArticleLipidomics: New perspectives on search for markers of neoplasiaЛипидомика: новые перспективы поиска маркеров неоплазийNekrasovaMaria EvgenievnaНекрасоваМария Евгеньевна

PhD student

аспирант

mashenka_90@mail.ruNazarovaNiso MirzoevnaНазароваНисо Мирзоевна

MD, PhD, Senior Researcher

д.м.н., в.н.с

grab2@yandex.ruStarodubtsevaNataliia LeonidovnaСтародубцеваНаталия Леонидовна

PhD, Head of Laboratory of Proteomics and Metabolomics of Human Reproduction

к.б.н., зав. лабораторией протеомики и метаболомики репродукции человека

n_starodubtseva@oparina4.ruChagovetsVitaliy ViktorovichЧаговецВиталий Викторович

PhD, Senior Researcher of Laboratory of Proteomics and Metabolomics of Human Reproduction

к.ф-м.н., с.н.с. лаборатории протеомики и метаболомики репродукции человека

vvchagovets@gmail.comKononikhinAlexey SergeevichКононихинАлексей Сергеевич

PhD, Researcher of Laboratory of Proteomics and Metabolomics of Human Reproduction

к.ф-м.н., научный сотрудник лаборатории протеомики и метаболомики репродукции человека

konoleha@yandex.ruFrankevichVladimir EvgenievichФранкевичВладимир Евгеньевич

PhD, Head of Department of Systems Biology in Reproduction

к.ф-м.н., руководитель отдела системной биологии в репродукции

v_frankevich@oparina4.ruPrilepskayaVera NikolaevnaПрилепскаяВера Николаевна

MD, PhD, Professor, Deputy Director for Science

д.м.н., профессор, зам. директора

VPrilepskaya@mail.ruResearch Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of RussiaФГБУ НЦАГиП им. академика В.И. Кулакова» Минздрава РоссииResearch Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of RussiaФГБУ НЦАГиП им. академика В.И. Кулакова Минздрава России150320173NO3 (2017)№3 (2017)344018022023Copyright ©; 2017, Bionika MediaCopyright ©; 2017, ООО «Бионика Медиа»2017Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/247899

Objective. To conduct a systematic analysis of the data available in the current literature on the role of lipids in carcinogenesis and the importance of lipid markers in the diagnosis of HPV-associated cervical diseases and to provide perspectives on the lipidomic analysis of cervical tissue in predicting the course of cervical neoplastic processes. Material and methods. The review includes data from 46 foreign articles published in the past 5 years and found in Pubmed and Scopus on this topic. Results. The paper describes a number of lipid markers of tissues in different organs for the early diagnosis of precancerous and cancerous lesions, by estimating the degree of diagnostic significance. Conclusion. It is necessary to conduct further studies aimed at identifying specif ic lipid markers for the early diagnosis and prognosis of human papillomavirus-associated cervical diseases.

Цель исследования. Провести систематический анализ данных, имеющихся в современной литературе, о роли липидов в процессе канцерогенеза, значении липидных маркеров в диагностике ВПЧ-ассоциированных заболеваний шейки матки и представить перспективы липидомного анализа тканей шейки матки для прогнозирования течения неопластических процессов шейки матки. Материал и методы. В обзор включены данные 46 зарубежных статей, найденных в Pubmed и Scopus по данной теме, опубликованных за последние 5 лет. Результаты. Описан ряд липидных маркеров тканей различных органов для ранней диагностики предраковых и раковых заболеваний с оценкой степени диагностической значимости. Заключение. Необходимо проведение дальнейших исследований, направленных на выявление специфических липидных маркеров, для ранней диагностики и прогнозирования течения заболеваний шейки матки, ассоциированных с вирусом папилломы человека.

cervical intraepithelial neoplasiahuman papillomaviruscervical cancerlipidomicsphospholipidsmass-spectrometryцервикальная интраэпителиальная неоплазиявирус папилломы человекарак шейки маткилипидомикафосфолипидымасс-спектрометрияВсемирный доклад о раковых заболеваниях. 2014. Available at: http://www. who.int/mediacentre/factsheets/fs297/ru/ [World report on cancer diseases. 2014. Available at: http://www.who.int/mediacentre/factsheets/fs297/en/ (in Russian)]Сухих Г.Т., Прилепская В.Н., ред. Профилактика рака шейки матки. Руководство для врачей. М.: МЕДпресс-информ; 2012. [Sukhikh G.T., Prilepskaya V.N., ed. Prophylaxis of cervical cancer. A guide for doctors. Moscow: MEDpress-inform; 2012. (in Russian)]Rozemeijer K., Penning C., Siebers A.G., Naber S.K., Matthijsse S.M., van Ballegooijen M. et al. Comparing SurePath, ThinPrepand conventional cytology as primary test method: SurePath is associated with increased CIN II(+) detection rates. Cancer Causes Control. 2016; 27(1): 15-25.Lee D.H., Hwang N.R., Lim M.C., Yoo C.W., Joo J., Kim J.Y. et al. Comparison of the performance of Anyplex II HPV HR, the Cobas 4800 human papillomavirus test and Hybrid Capture 2. Ann. Clin. Biochem. 2016; 53(Pt 5): 561-7.White C., Bakhiet S., Bates M., Keegan H., Pilkington L., Ruttle C. et al. Triage of LSIL/ASC-US with p16/Ki-67 dual staining and human papillomavirus testing: a 2-year prospective study. Cytopathology. 2016; 27(4): 269-76.Özgü E., Yildiz Y., Özgü B.S., Öz M., Daniçman N., Güngör T. Efficacy of a real time optoelectronic device (TruScreen™) in detecting cervical intraepithelial pathologies: a prospective observational study. J. Turk. Ger. Gynecol. Assoc. 2015; 16(1): 41-4.Du X., Sai X., Liu A., Fu X., Li J., Meng Y. Diagnostic value of TruScreen in cervical lesions screening. Zhonghua Yi Xue Za Zhi. 2015; 95(29): 2379-81.Practice Bulletin No.157: Cervical cancer screening and prevention. Obstet. Gynecol. 2016; 127(1): e1-e20.Escobar-Hoyos L.F., Yang J., Zhu J., Cavallo J.A., Zhai H., Burke S. Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker. Mod. Pathol. 2014; 27(4): 621-30.Zoidakis I., Lygirou V., Kontostathi G., Vlahou A., Anagnou N.P., Pappa K.I. Cofilin-1 and Cathepsin-D are putative early cervical cancer biomarkers. EUROGIN 2015 - HPV infection and related cancers. 2015.Zhao Q., He Y., Wang X.L., Zhang Y.X., Wu Y.M. Differentially expressed proteins among normal cervix, cervical intraepithelial neoplasia and cervical squamous cell carcinoma. Clin. Transl. Oncol. 2015; 17(8): 620-31.Tsuchida N., Murugan A.K., Grieco M. Kirsten Ras* oncogene: Significance of its discovery in human cancer research. Oncotarget. 2016; 7(29): 46717-33.Fiorentino F.P., Tokgün E., Solé-Sánchez S., Giampaolo S., Tokgün O., Jauset T. et al. Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation. Oncotarget. 2016; 7(21): 31014-28.Juneja S., Chaitanya N.B., Agarwal M. Immunohistochemical expression of BCL-2 in oral epithelial dysplasia and oral squamous cell carcinoma. Indian J. Cancer. 2015; 52(4): 505-10.Parvin S., Islam M.S., Al-Mamun M.M., Islam M.S., Ahmed M.U., Kabir E.R., Hasnat A. Association of BRCA1, BRCA2, RAD51 and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population. Breast Cancer. 2016; Apr. 11.Swierczynski J., Hebanowska A., Sledzinski T. Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer. World J. Gastroenterol. 2014; 20(9): 2279-303.Czerska M., Zielinski M., Gromadzinska J. Isoprostanes - а novel major group of oxidative stress markers. Int. J. Occup. Med. Environ. Health. 2016; 29(2): 179-90.Vauzour D., Martinsen A., Layé S. Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects? Neurochem. Int. 2015; 89: 63-74.Coffey M.J., Torretti B., Mancuso P. Adipokines and cysteinyl leukotrienes in the pathogenesis of asthma. J. Allergy (Cairo). 2015; 2015: 157919.Jiang S., Li Y., Lin S., Yangc H., Guand Xin-yuan, Zhoua H. et al. Mass spectrometry-based lipidomics analysis using methyl tert-butyl ether extraction in human hepatocellular carcinoma tissues. Analyt. Methods. 2015; 19(7): 8466-71.Goto T., Terada N., Inoue T., Kobayashi T., Nakayama K., Okada Y. et al. Decreased expression of lysophosphatidylcholine (16:0/OH) in high resolution imaging mass spectrometry independently predicts biochemical recurrence after surgical treatment for prostate cancer. Prostate. 2015; 75(16): 1821-30.Burch T.C., Isaac G., Booher C.L., Rhim J.S., Rainville P., Langridge J. et al. Comparative metabolomic and lipidomic analysis of phenotype stratified prostate cells. PLoS One. 2015; 10(8): e0134206.Li J., Ren S., Piao H.L., Wang F., Yin P., Xu C. et al. Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer. Scientific Rep. 2016; 6: 20984.Sapandowski A., Stope M., Evert K., Evert M., Zimmermann U., Peter D. et al. Cardiolipin composition correlates with prostate cancer cell proliferation. Mol. Cell. Biochem. 2015; 410(1-2): 175-85.Kiebish M.A., Han X., Cheng H., Chuang J.H., Seyfried T.N. Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer. J. Lipid Res. 2008; 49(12): 2545-56.Wang S., Chen X., Luan H., Gao D., Lin S., Cai Z. et al. Matrix-assisted laser desorption/ionization mass spectrometry imaging of cell cultures for the lipidomic analysis of potential lipid markers in human breast cancer invasion. Rapid Commun. Mass Spectrom. 2016; 30(4): 533-42.Kim I.C., Lee J.H., Bang G., Choi S.H., Kim Y.H., Kim K.P. et al. Lipid profiles for HER2-positive breast cancer. Anticancer Res. 2013; 33(6): 2467-72.Doria M.L., Cotrim Z., MacEdo B., Simoes C., Domingues P., Helguero L., Domingues M.R. Lipidomic approach to identify patterns in phospholipid profiles and define class differences in mammary epithelial and breast cancer cells. Breast Cancer Res. Treat. 2012; 133(2): 635-48.Cifkovâ E., HolcapekM., Lisa M., Vrána D., Gatek J., Melichar B. Determination of lipidomic differences between human breast cancer and surrounding normal tissues using HILIC-HPLC/ESI-MS and multivariate data analysis. Anal. Bioanal. Chem. 2015; 407(3): 991-1002.Hilvo M., Denkert C., Lehtinen L., Müller B., Brockmöller S., Seppänen-Laakso T. et al. Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res. 2011; 71(9): 3236-45.Kang S., Lee A., Park Y.S., Lee S.C., Park S.Y., Han S.Y. et al. Alteration in lipid and protein profiles of ovarian cancer similarity to breast cancer. Int. J. Gynecol. Cancer. 2011; 21(9): 1566-72.Kim I.C., Bang G., Lee J.H., Kim K.P., Kim Y.H., Kim H.K., Chung J. Low C24-OH and C22-OH sulfatides in human renal cell carcinoma. J. Mass Spectrom. 2014; 49(5): 409-16.Park Y.S., Yoo C.W., Lee S.C., Park S.J., Oh J.H., Yoo B.C. et al. Lipid profiles for intrahepatic cholangiocarcinoma identified using matrix-assisted laser desorption/ionization mass spectrometry. Clin. Chim. Acta. 2011; 412(21-22): 1978-82.Morita Y., Sakaguchi T., Ikegami K., Goto-Inoue N., Hayasaka T., Hang V.T. et al. Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression. J. Hepatol. 2013; 59(2): 292-9.Goto T., Terada N., Inoue T., Nakayama K., Okada Y., Yoshikawa T. et al. The expression profile of phosphatidylinositol in high spatial resolution imaging massspectrometry as a potential biomarker for prostate cancer. PLoS One. 2014; 9(2): e90242.Jiang Y., DiVittore N.A., Young M.M., Jia Z., Xie K., Ritty T.M. et al. Altered sphingolipid metabolism in patients with metastatic pancreatic cancer. Biomolecules. 2013; 3(3): 435-48.Ryu J., Bang G., Lee J.H., Choi Sh. Lipid MALDI MS profiling accurately distinguishes papillary thyroid carcinoma from normal tissue. J. Proteomics Bioinformatics. 2013; 6(4): 65-71.Ishikawa S., Tateya I., Hayasaka T., Masaki N., Takizawa Y., Ohno S. et al. Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer. PLoS One. 2012; 7(11): e48873.Marien E., Meister M., Muley T., Fieuws S., Bordei S., Derua R. et al. Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles. Int. J. Cancer. 2015; 137(7): 539-48.Marien E., Meister M., Muley T., Gomez Del Pulgar T., Derua R., Spraggins J.M. et al. Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma. Oncotarget. 2016; 7(11): 12582-97.Kwon S.Y., Choi S.H., Park Y.S., Park D.Y., Park Y.I., Hwang I. et al. Lipid MALDI MS profiles of gastric cancer. Open Proteomics Journal. 2015; 7: 1-4.Ching L.K., Gounder P.P., Bulkow L., Spradling P.R., Bruce M., Negus S. et al. Incidence of hepatocellular carcinoma according to hepatitis B virus genotype in Alaska Native people. Liver Int. 2016; 36(10): 1507-15.Tornesello M.L., Buonaguro L., Izzo F., Buonaguro F.M. Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections. Oncotarget. 2016; 7(18): 25087-102.Chen S., Yin P., Zhao X., Xing W., Hu C., Zhou L., Xu G. Serum lipid profiling of patients with chronic hepatitis B, cirrhosis and hepatocellular carcinoma by ultra fast LC/IT-TOF MS. Electrophoresis. 2013; 34(19): 2848-56.Passos-Castilho A.M., Carvalho V.M., Cardozo K.H., Kikuchi L., Chagas A.L., Gomes-Gouveá M.S. et al. Serum lipidomic profiling as a useful tool for screening potential biomarkers of hepatitis B-related hepatocellular carcinoma by ultraperformance liquid chromatography-mass spectrometry. BMC Cancer. 2015; 15: 985.