Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media24814610.18565/aig.2018.3.16-21ArticlesСтатьиResearch ArticleEffects of anthropogenic chemicals on reproductionВлияние антропогенных химических веществ на репродукциюSyrkashevaAnastasia GrigorievnaСыркашеваАнастасия Григорьевна

M.D., Ph.D., Researcher of the IVF Department

к.м.н., научный сотрудник отделения вспомогательных технологий в лечении бесплодия

a_syrkasheva@oparina4.ruDolgushinaNataliya VitalievnaДолгушинаНаталия Витальевна

M.D., Ph.D., M.P.H., Head of R&D Department

д.м.н., руководитель Службы научно-организационного обеспечения

n_dolgushina@oparina4.ruYarotskayaEkaterina LvovnaЯроцкаяЕкатерина Львовна

M.D., Ph.D., Head of the Department for International Cooperation

д.м.н., зав. отделом международного сотрудничества

e_yarotskaya@oparina4.ruResearch Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaФГБУ НЦАГиП им. академика В.И. Кулакова Минздрава России150320183NO3 (2018)№3 (2018)162118022023Copyright ©; 2018, Bionika MediaCopyright ©; 2018, ООО «Бионика Медиа»2018Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/248146

Objective. To carry out a systematic analysis of the data available in the current literature on the effects of some anthropogenic chemicals on human fertility, including on the effectiveness of assisted reproductive technology programs. Material and methods. The review includes the articles by foreign and Russian authors on this topic, which have been published in the Pubmed journals in the past 10 years. Results. The authors analyze the literature data on the effects of heavy metals, phthalates, and bisphenol A on various aspects of human reproductive function. They present data on the possible pathogenetic mechanisms of action of anthropogenic chemicals on the quality of gametes and the efficiency of treatment for infertility. Conclusion. It is necessary to further study the molecular mechanisms of negative action of toxicants on human fertility in order to determine management tactics in infertility patients.

Цель работы. Провести систематический анализ данных, имеющихся в современной литературе, относительно влияния некоторых антропогенных химических веществ на фертильность человека, в том числе на эффективность программ вспомогательных репродуктивных технологий (ВРТ). Материал и методы. В обзор включены статьи зарубежных и отечественных авторов по данной теме, опубликованные в журналах системы Pubmed за последние 10 лет. Результаты. Проанализированы литературные данные о влиянии тяжелых металлов, фталатов и бисфенола А на различные аспекты репродуктивной функции человека. Представлены данные о возможных патогенетических механизмах влияния антропогенных химических веществ на качество половых клеток и эффективность лечения бесплодия. Заключение. Необходимо дальнейшее изучение молекулярных механизмов негативного влияния токсикантов на фертильность человека с целью определения тактики ведения пациентов с бесплодием.

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