Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media24861110.18565/aig.2020.1.5-11ArticlesСтатьиReview ArticleMaternal hemodynamics and preeclampsiaМатеринская гемодинамика и преэклампсияNagoevTemirlan M.НагоевТемирлан Мухамедович

Postdoc of High Risk Pregnancy Department

аспирант 1 отделения патологии беременности

tamn94@mail.ruMuminovaKamilla T.МуминоваКамилла Тимуровна

Junior researcher of High Risk Pregnancy Department

младший научный сотрудник 1 отделения патологии беременности

kamika91@mail.ruKhodzhaevaZulfiya S.ХоджаеваЗульфия Сагдуллаевна

MD , Professor, Head of High Risk Pregnancy Department.

д.м.н., заведующий 1-м акушерского отделения патологии беременности

zkhodjaeva@mail.ruKholinAlexey M.ХолинАлексей Михайлович

obstetrician-gynecologist, High Risk Pregnancy Department.

врач акушер-гинеколог 1-м акушерского отделения патологии беременности

a_kholin@oparina4.ruZiganshinaMarina M.ЗиганшинаМарина Михайловна

Senior researcher. Dept of clinical immunology

старший научный сотрудник лаборатории клинической иммунологии

m_ziganshina@oparina4.ruKozlovaAnastasiya А.КозловаАнастасия Анатольевна

resident

клинический ординатор

aakozlova.box@gmail.comMartirosyanYana O.МартиросянЯна Ованнесовна

clinical resident of the Department of Obstetrics, Gynecology, Perinatology and Reproductive medicine of the Medical Faculty

ординатор кафедры акушерства, гинекологии, перинатологии и репродуктологии

marti-yana@yandex.ruAcademician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава РоссииAcademician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology Ministry of Health of RussiaПервый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)150120201NO1 (2020)№1 (2020)51118022023Copyright ©; 2020, Bionika MediaCopyright ©; 2020, ООО «Бионика Медиа»2020Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/248611

The paper includes scientific publications (mainly systematic reviews and meta-analyses) by foreign and Russian authors over the past 10 years, which have been found in the Pubmed database and on other available search platforms, such as Cochrane, Web of Science, MedLine, and Google Scholar, based on which the paper generalizes and updates the existing data on the features of maternal hemodynamics in preeclampsia (PE), the possibility of its early prediction and choice of therapy, by taking into consideration the indicators of the maternal cardiovascular system. It presents the possibilities of studying maternal hemodynamics using its current indicators, as well as new approaches to elucidating its role in the pathogenesis of early and late PE and data on the possible effect of the endothelial glycocalyx on the hemodynamic profile of a pregnant woman. Further studies are needed to stratify women according to their hemodynamic prof ile, by simultaneously investigating the endothelial glycocalyx in order to elucidate the role of maternal hemodynamics in the genesis of PE and by elaborating individualized therapeutic approaches.

Изучены научные публикации за последние 10 лет (преимущественно систематические обзоры и метаанализы) зарубежных и отечественных авторов, обнаруженные в базе данных Pubmed и на других доступных поисковых платформах: Cochrane, Web of Science, MedLine, Google Scholar, на основе которых в статье обобщены и актуализированы существующие данные об особенностях материнской гемодинамики при преэклампсии (ПЭ), возможности ее ранней предикции и подбора терапии с учетом показателей сердечно-сосудистой системы матери. Представлены возможности изучения материнской гемодинамики с использованием современных показателей, новые подходы к выяснению ее роли в патогенезе ранней и поздней ПЭ, данные о возможном влиянии состояния эндотелиального гликокаликса на гемодинамический профиль беременной. Необходимо проведение дальнейших исследований по стратификации женщин по гемодинамическому профилю с одновременным изучением эндотелиального гликокаликса для выяснения роли мaтeринской гемодинамики в генезе ПЭ и разработки индивидуализированных терапевтических подходов.

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