Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media24863410.18565/aig.2020-1.40-46ArticlesСтатьиReview ArticleMicroRNAs and premature ovarian insufficiencyМикроРНК и преждевременная овариальная недостаточностьDmitrievaMargarita L.ДмитриеваМаргарита Леонидовна

PhD, Assistant of the Department of Obstetrics and Gynecology

к.м.н., ассистент кафедры акушерства гинекологии

margarita0708@yandex.ruTikhonovskayaOlga A.ТихоновскаяОльга Анатольевна

MD, Professor of the Department of Obstetrics and Gynecology

д.м.н., профессор кафедры акушерства и гинекологии

tikhonovskaya2012@mail.ruRomanovaAnastasia A.РомановаАнастасия Александровна

student of the 2nd course of the Faculty of Medicine.

студент 3 курса лечебного факультета

doch.aleksandraromanova@gmail.comLogvinovSergey V.ЛогвиновСергей Валентинович

MD, Professor, Head of the Department of Histology, Embryology and Cytology

д.м.н., профессор, зав. кафедрой гистологии, эмбриологии и цитологии, проректор по учебной работе

s_logvinov@mail.ruSiberian State Medical University Ministry of Health of RussiaФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России150120201NO1 (2020)№1 (2020)404618022023Copyright ©; 2020, Bionika MediaCopyright ©; 2020, ООО «Бионика Медиа»2020Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/248634

The relevance of studying the role of microRNAs in the pathogenesis of diseases of organs and systems is beyond question. The reproductive system is no exception. Since the early 2000s, many studies have been conducted to identify microRNAs in the ovaries. A literature review demonstrates the important role of microRNAs in folliculogenesis, including as regulators of apoptosis of granulosa cells, ovulation, and luteinization. It is established that microRNAs can be important regulatory molecules directly involved in premature ovarian insufficiency and polycystic ovary syndrome. MicroRNAs can become biological markers of ovarian reserve, which is of great importance in reproductology.

Актуальность изучения роли микроРНК в патогенезе заболеваний органов и систем не вызывает сомнения. Репродуктивная система не является исключением. С начала 2000-х гг. было проведено множество исследований по выявлению микроРНК в яичниках. Обзор литературы демонстрирует важную роль микроРНК в фолликулогенезе, в том числе в качестве регуляторов апоптоза в клетках гранулезы, при овуляции и лютеинизации. Установлено, что микроРНК могут быть важными регуляторными молекулами, участвующими непосредственно в формировании преждевременной овариальной недостаточности и синдрома поликистозных яичников. МикроРНК могут стать биологическими маркерами овариального резерва, что имеет большое значение в репродуктологии.

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