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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Obstetrics and Gynecology</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics and Gynecology</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство и гинекология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0300-9092</issn><issn publication-format="electronic">2412-5679</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">248866</article-id><article-id pub-id-type="doi">10.18565/aig.2020.5.78-84</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">PERINATAL OUTCOMES OF TWIN PREGNANCIES WITH BIRTH WEIGHT DISCORDANCE</article-title><trans-title-group xml:lang="ru"><trans-title>ОЦЕНКА ПЕРИНАТАЛЬНЫХ ИСХОДОВ ПРИ ДИСКОРДАНТНОМ ВЕСЕ НОВОРОЖДЕННЫХ ИЗ ДВОЙНИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>KOSTYUKOV</surname><given-names>Kirill V.</given-names></name><name xml:lang="ru"><surname>КОСТЮКОВ</surname><given-names>Кирилл Витальевич</given-names></name></name-alternatives><bio xml:lang="en"><p>Ph.D., Senior Researcher at the Department of Fetal Medicine, Institute of Obstetrics; Physician at the Department of Functional and Ultrasound Diagnostics, Department of Diagnostic Imaging</p></bio><bio xml:lang="ru"><p>к.м.н., старший научный сотрудник отдела медицины плода Института акушерства, врач отделения функциональной и ультразвуковой диагностики отдела визуальной диагностики</p></bio><email>kostyukov_k@yahoo.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>IONOV</surname><given-names>Oleg V.</given-names></name><name xml:lang="ru"><surname>ИОНОВ</surname><given-names>Олег Вадимович</given-names></name></name-alternatives><bio xml:lang="en"><p>Ph.D., Head of the A.G. Antonov Neonatal Intensive Care Unit, Institute of Neonatology and Pediatrics, V.I. Kulakov NMRC for OG&amp;P of Minzdrav of Russia; Associate Professor at the Department of Neonatology, Faculty of Pediatrics of I.M. Sechenov First MSMU</p></bio><bio xml:lang="ru"><p>к.м.н., заведующий отделением реанимации и интенсивной терапии им. проф. Антонова А.Г. Института неонатологии и педиатрии ФГБУ «НМИЦ АГП им. акад. В.И. Кулакова» Минздрава России, доцент кафедры неонатологии Клинического института детского здоровья им. Н.Ф. Филатова ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский университет).</p></bio><email>o_ionov@oparina4.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>SHAKAYA</surname><given-names>Marika N.</given-names></name><name xml:lang="ru"><surname>ШАКАЯ</surname><given-names>Марика Нугзаровна</given-names></name></name-alternatives><bio xml:lang="en"><p>Ph.D., Teaching Assistant at the Department of Neonatology, N.F. Filatov Clinical Institute of Children’s Health, I.M. Sechenov First MSMU of Minzdrav of Russia (Sechenov University); Emergency Neonatologist at the A.G. Antonov Neonatal Intensive Care Unit, Institute of Neonatology and Pediatrics, V.I. Kulakov NMRC for OG&amp;P of Minzdrav of Russia</p></bio><bio xml:lang="ru"><p>ассистент кафедры неонатологии клинического института детского здоровья им. Н.Ф. Филатова ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский Университет), врач-неонатолог отделения реанимации и интенсивной терапии новорожденных им. проф. А.Г. Антонова ФГБУ «НМИЦ АГП им. акад. В.И. Кулакова» Минздрава России</p></bio><email>m_shakaya@oparina4.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-05-15" publication-format="electronic"><day>15</day><month>05</month><year>2020</year></pub-date><issue>5</issue><issue-title xml:lang="en">NO5 (2020)</issue-title><issue-title xml:lang="ru">№5 (2020)</issue-title><fpage>78</fpage><lpage>84</lpage><history><date date-type="received" iso-8601-date="2023-02-18"><day>18</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, ООО «Бионика Медиа»</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/0300-9092/article/view/248866">https://journals.eco-vector.com/0300-9092/article/view/248866</self-uri><abstract xml:lang="en"><p>Birth weight discordance in multiple pregnancies is not uncommon, and signif icant birth weight difference is a risk factor for adverse outcomes. Aim. To investigate perinatal outcomes of twin pregnancies with significant (over 25%) birth weight discordance. Material and methods. The study comprised 485 pregnant women and their 959 newborns. Two groups were formed based on the presence or absence of birth weight discordance, in which the antenatal and neonatal periods were analyzed. Results. Birth weight discordance was detected in 18.8% of twins. The antenatal mortality rate in groups with and without birth weight discordance was 6.6% and 1.3%, respectively, p = 0.008. The median gestational age of twins with and without birth weight discordance was 33.6 and 36.0 weeks, respectively, p &lt;0.001. Twins with birth weight discordance had significantly lower birth weight (1654g) than concordant twins (2386g), p &lt;0.001. The neonatal mortality rate of twins with birth weight discordance was 9.1% compared with 1% in concordant twins, p &lt;0.001. Discordant twins had higher neonatal morbidity (21.6%) than concordant twins (6.1%), (p = 0.002). Conclusion. Twin birth weight discordance is a risk factor for antenatal death, premature birth, and surgical delivery. At the same time, birth weight discordance is associated with high neonatal morbidity (respiratory and neurological disorders) and mortality.</p></abstract><trans-abstract xml:lang="ru"><p>Дискордантный рост плодов при многоплодии встречается нередко, а выраженное различие в массе является фактором неблагоприятного исхода. Цель. Оценить перинатальные исходы при выраженной (более 25%) дискордантности веса новорожденных из двойни. Материалы и методы. Проведено исследование 485 беременных и их 959 новорожденных. На основании разницы массы тела новорожденных были сформированы две группы - с дискордантностью и без нее, в которых проводилась оценка антенатального и неонатального периодов. Результаты. Дискордантность выявлена у 18,8% двоен. Частота антенатальной смертности в группе с дискордантностью составила 6,6%, без - 1,3%, р=0,008. Медиана гестационного возраста новорожденных с дискордантным весом составила 33,6 недель, при симметричном - 36, р&lt;0,001. Вес новорожденных с дискордантностью был значительно меньше - 1654 г и без - 2386 г, р&lt;0,001. Частота неонатальной смертности при дискордантном весе - 9,1%, при симметричном - 1%, р&lt;0,001. Частота неонатальной заболеваемости преобладала у новорожденных с дискордантным весом - 21,6% и 6,1% (р=0,002). Заключение. Дискордантность при двойне является фактором риска антенатальной гибели, преждевременных родов и оперативного родоразрешения. В то же время дискордантность повышает частоту неонатальной заболеваемости (респираторные и неврологические нарушения) и смертности.</p></trans-abstract><kwd-group xml:lang="en"><kwd>multiple gestation pregnancy</kwd><kwd>fetal growth restriction of one twin</kwd><kwd>birth weight discordance</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>многоплодная беременность</kwd><kwd>замедление роста одного плода из двойни</kwd><kwd>дискордантный вес</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Martin J.A., Hamilton B.E., Osterman M.J. Three decades of twin births in the United States, 1980-2009. NCHS Data Brief. 2012 Jan; (80): 1-8.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Blickstein I. Normal and abnormal growth of multiples. Semin. Neonatol. 2002; 7(3): 177-85. https://dx.doi.org/10.1053/siny.2002.0105.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Hack K.E., Derks J.B., Elias S.G., Franx A., Roos E.J., Voerman S.K. et al. Increased perinatal mortality and morbidity in monochorionic versus dichorionic twin pregnancies: clinical implications of a large Dutch cohort study. BJOG. 2008; 115(1): 58-67. https://dx.doi.org/10.1111/j.1471-0528.2007.01556.x.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Visintin C., Mugglestone M.A., James D., Kilby M.D.; Guideline Development Group. Antenatal care for twin and triplet pregnancies: summary of NICE guidance. BMJ. 2011; 343: d5714. https://dx.doi.ois/10.1136/bmj.d5714.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 134: fetal growth restriction. Obstet. Gynecol. 2013; 121(5): 1122-33. https://dx.doi.org/10.1097/01.AOG.0000429658.85846.f9.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Lewi L., Devlieger R., De Catte L., Deprest J. Growth discordance. Best Pract. Res. Clin. Obstet. Gynaecol. 2014; 28(2): 295-303. https://dx.doi. org/10.1016/j.bpobgyn.2013.12.003.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Amaru R.C., Bush M.C., Berkowitz R.L., Lapinski R.H., Gaddipati S. Is discordant growth in twins an independent risk factor for adverse neonatal outcome? Obstet. Gynecol. 2004; 103(1): 71-6. https://dx.doi.org/10.1097/01. AOG.0000104060.37475.29.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Hartley R.S., Hitti J., Emanuel I. Size-discordant twin pairs have higher perinatal mortality rates than non discordant pairs. Am. J. Obstet. Gynecol. 2002; 187(5): 1173-8. https://dx.doi.org/10.1067/mob.2002.126961.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>D’Antonio F., Odibo A.O., Prefumo F., Khalil A., Buca D., Flacco M.E. et al. Weight discordance and perinatal mortality in twin pregnancy: systematic review and meta-analysis. Ultrasound Obstet. Gynecol. 2018; 52(1): 11-23. https:// dx.doi.org/10.1002/uog.18966.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Miller J., Chauhan S.P., Abuhamad A.Z. Discordant twins: diagnosis, evaluation and management. Am. J. Obstet. Gynecol. 2012; 206(1): 10-20. https://dx.doi. org/10.1016/j.ajog.2011.06.075.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Machado M., Lima T.E., Ferreira L.M., Rodrigues F., Henriques R., Afonso E. Perinatal outcome in relation to chorionicity in twin pregnancy. Acta Med. Port. 2017; 30(1): 12-6. https://dx.doi.org/10.20344/amp.7133.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>D’Antonio F., Khalil A., Dias T., Thilaganathan B. Early fetal loss in monochorionic and dichorionic twin pregnancies: analysis of the Southwest Thames Obstetric Research Collaborative (STORK) multiple pregnancy cohort. Ultrasound Obstet. Gynecol. 2013; 41(6): 632-6. https://dx.doi.org/10.1002/uog.12363.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Carter E.B., Bishop K.C., Goetzinger K.R., Tuuli M.G., Cahill A.G. The impact of chorionicity on maternal pregnancy outcomes. Am. J. Obstet. Gynecol. 2015; 213(3): 390. e1-7.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Al Riyami N., Al-Rusheidi A., Al-Khabori M. Perinatal outcome of monochorionic in comparison to dichorionictwin pregnancies. Oman Med. J. 2013; 28(3): 173-7. https://dx.doi.org/10.5001/omj.2013.49</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Fumagalli M., Schiavolin P., Bassi L., Groppo M., Uccella S., De Carli A. et al. The impact of twin birth on early neonatal outcomes. Am. J. Perinatol. 2016; 33(1): 63-70. https://dx.doi.org/10.1055/s-0035-1556881.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Lee H.J., Kim S.H., Chang K.H., Sung J.H., Choi S.J., Oh S.Y. et al. Gestational age at delivery and neonatal outcome in uncomplicated twin pregnancies: what is the optimal gestational age for delivery according to chorionicity? Obstet. Gynecol. Sci. 2016; 59(1): 9-16. https://dx.doi.org/10.5468/ogs.2016.59.L9.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>McLennan A.S., Gyamfi-Bannerman C., Ananth C.V., Wright J.D., Siddiq Z., D’Alton M.E. et al. The role of maternal age in twin pregnancy outcomes. Am. J. Obstet. Gynecol. 2017; 217(1): 80. e8. https://dx.doi.org/10.1016/j. ajog.2017.03.002.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Garabedian C., Poulain C., Duhamel A., Subtil D., Houflin-Debarge V., Deruelle P. Intrapartum management of twin pregnancies: are uncomplicated monochorionic pregnancies more at risk of complications than dichorionic pregnancies? Acta Obstet. Gynecol. Scand. 2015; 94(3): 301-7. https://dx.doi. org/10.1111/aogs.12558.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Callaghan W.M., MacDorman M.F., Rasmussen S.A., Qin C., Lackritz E.M. The contribution of preterm birth to infant mortality rates in the United States. Pediatrics. 2006; 118(4): 1566-73. https://dx.doi.o^/10.1542/peds.2006-0860.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Masheer S., Islam Z., Dileep D., Munim S. Twin chorionicity and prospective stillbirth risk: experience at a tertiary care hospital. J. Pak. Med. Assoc. 2017; 67(3): 360-4.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Di Mascio D., Acharya G., Khalil A., Odibo A., Prejumo F., Liberati M. et al. Birthweight discordance and neonatal morbidity in twin pregnancies: A systematic review and meta-analysis. Acta Obstet. Gynecol. Scand. 2019; 98(10): 1245-57. https://dx.doi. org/10.1111/aogs.13613.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Timur H., Aksoy R.T., Tokmak A., Timur B., Coskun B., Uygur D., Danisman N. Maternal and perinatal outcomes of dichorionic diamniotic twin pregnancies diagnosed with vanishing twin syndrome: a retrospective analysis from a single clinical center. Ginekol. Pol. 2018; 89(1): 30-4. https://dx.doi.org/10.5603/ GP.a2018.0006.</mixed-citation></ref></ref-list></back></article>
