Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media32965110.18565/aig.2020.9.217-224ArticlesСтатьиResearch Article“Nonclassical effects” of vitamin D in menopausal women«Неклассические» эффекты витамина D у женщин в менопаузеAndreevaElena N.АндрееваЕлена Николаевна

MD, PhD, Professor

д.м.н., профессор, заместитель директора Центра - директор Института репродуктивной медицины, зав. отделением эндокринной гинекологии, профессор кафедры эндокринологии

SheremetyevaEkaterina V.ШереметьеваЕкатерина Викторовна

MD, PhD

к.м.н., ведущий научный сотрудник отделения эндокринной гинекологии

sl98lk@yandex.ruManushakyanGrigory A.МанушакянГригорий Арамович

MD, Doctor of the Department of Personalized Medicine

врач отделения персонифицированной медицины

National Medical Research Center of Endocrinology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава РоссииA.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России"MEDSI" Companies GroupАО Группа компаний «МЕДСИ»150920209NO9 (2020)№9 (2020)21722414042023Copyright ©; 2020, Bionika MediaCopyright ©; 2020, ООО «Бионика Медиа»2020Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/329651

Traditionally, vitamin D is primarily associated with calcium and phosphorus metabolism and its impact on bone mineral density. This “classical” role of vitamin D has been well investigated; however, the ideas of vitamin D have begun to expand in the 21st century. Vitamin D is also called hormone D; and this hormone is important for producing a wide range of physiological processes in the body. When there is an age-related decrease in sex steroids in a woman, a number of pathological conditions and diseases in postmenopausal women can be caused by deficiency of another significant hormone - hormone D. An update shows that low blood vitamin D levels can be implicated in the pathogenesis of metabolic syndrome and type 2 diabetes mellitus and in the formation of a set of vasomotor complaints during menopause, Alzheimer’s disease, psychological disorders, cardiovascular diseases, decreased physical activity, and other “non-classical” effects. Numerous studies support the enormous impact of vitamin D on women’s health throughout life. Conclusion. The study of the impact of vitamin D deficiency on the development and course of somatic diseases, affective states and cognitive behavioral manifestations during menopause and the efficacy colecalciferol for their prevention and treatment are of great theoretical and practical value.

Традиционно витамин D прежде всего ассоциируется с кальциево-фосфорным обменом и с его влиянием на минеральную плотность костной ткани. Эта «классическая» роль витамина D хорошо изучена, однако в XXI в. представления о витамине D начали расширяться. Витамин D также называют D-гормоном, и этот гормон важен для обеспечения широкого спектра физиологических процессов организма. В условиях возрастного снижения половых стероидов, в основе ряда патологических состояний и заболеваний у женщин постменопаузального периода лежит дефицит еще одного значимого гормона - D-гормона. Согласно современным данным, низкие значения витамина D в крови могут быть вовлечены в патогенез метаболического синдрома, сахарного диабета 2 типа, формирования комплекса вазомоторных жалоб в периоде менопаузы, болезни Альцгеймера, нарушений психологического статуса, сердечно-сосудистых заболеваний, снижения физической активности и других «неклассических» эффектов. Многочисленные исследования подтверждают огромное влияние витамина D на женское здоровье в течение всей жизни. Заключение. Изучение влияния дефицита витамина D на развитие и течение соматических заболеваний, аффективных состояний и когнитивно-поведенческих проявлений во время климактерия и эффективность применения колекальциферола для их профилактики и лечения представляют большую теоретическую и практическую ценность.

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