Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media32969410.18565/aig.2017.6.18-24ArticlesСтатьиReview ArticleON THE PATHOGENESIS OF REPRODUCTIVE DISORDERS IN WOMEN WITH OBESITYК ВОПРОСУ О ПАТОГЕНЕЗЕ РЕПРОДУКТИВНЫХ НАРУШЕНИЙ У ЖЕНЩИН С ОЖИРЕНИЕМVedzizhevaElina RuslanovnaВедзижеваЭлина Руслановна

graduate student at Research Department of Women’s Health

аспирант НИО женского здоровья НИЦ

ishu2009@mail.ruKuznetsovaIrina VsevolodovnaКузнецоваИрина Всеволодовна

MD, professor, chief researcher at Research Department of Women’s Health

д.м.н., профессор, г.н.с. НИО женского здоровья НИЦ

ms_smith@list.ruUspenskayaYulia BorisovnaУспенскаяЮлия Борисовна

PhD, leading researcher at Research Department of Women’s Health

к.м.н., в.н.с.. НИО женского здоровья НИЦ

GitelEvgenij PavlovichГительЕвгений Павлович

PhD, associate director on laboratory technologies

к.м.н., зам. директора по лабораторным технологиям

VasilyevaIrina VadimovnaВасильеваИрина Вадимовна

senior researcher at Research Department of Women’s Health

с.н.с. НИО женского здоровья НИЦ

I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaФГБОУ ВО Первый московский медицинский университет им. И.М. Сеченова Минздрава России151220176NO6 (2017)№6 (2017)182514042023Copyright ©; 2017, Bionika MediaCopyright ©; 2017, ООО «Бионика Медиа»2017Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/329694

Objective. To carry out a systematic analysis of the data available in the current literature on the role of adipokines in reproductive dysfunction in obese women. Material and methods. For analysis, foreign and Russian works published in the past 15 years were sought for in the international citation system Pubmed. Results. The modern theories of the mechan ism of reproductive disorders in obese women were described; the key factors of impact of adipose tissue on fertility were described. The importance of regulation of the body’s metabolic processes in restoring fertility and preparing women for pregnancy was highlighted. Conclusion. Most current studies often show conflicting and ambiguous results, which leads to the need for further research.

Цель исследования. Провести систематический анализ литературных данных относительно роли адипокинов в нарушении репродуктивной функции у женщин с ожирением. Материал и методы. С целью проведения анализа был осуществлен поиск зарубежных и отечественных публикаций в международной системе цитирования Pubmed, опубликованных за последние 15 лет. Результаты. Описаны современные теории механизма развития репродуктивных нарушений у женщин с ожирением, обсуждены ключевые факторы влияния жировой ткани на фертильность. Подчеркнута важность регулирования метаболических процессов организма в процессе восстановления фертильности и подготовки женщины к беременности. Заключение. Большинство современных исследований часто демонстрируют противоречивые и неоднозначные результаты, что приводит к необходимости проведения дальнейших изысканий.

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