Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media32969510.18565/aig.2017.6.26-34ArticlesСтатьиReview ArticleACTIVE VITAMIN D METABOLITES IN THE THERAPY OF MENOPAUSAL OSTEOPOROSISАКТИВНЫЕ МЕТАБОЛИТЫ ВИТАМИНА D В ТЕРАПИИ МЕНОПАУЗАЛЬНОГО ОСТЕОПОРОЗАKuznetsovaIrina VsevolodovnaКузнецоваИрина Всеволодовна

MD, Professor of the 1st Department of Obstetrics and Gynecology, Faculty of Physiology

д.м.н., профессор кафедры акушерства и гинекологии № 1 лечебного факультета

I.M. Sechenov First Moscow State Medical UniversityФГАОУ ВПО Первый московский государственный медицинский университет им. И.М. Сеченова151220176NO6 (2017)№6 (2017)263414042023Copyright ©; 2017, Bionika MediaCopyright ©; 2017, ООО «Бионика Медиа»2017Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/329695

Objective. To carry out a systematic analysis of the data available in the literature on the problem of therapy with active vitamin D metabolites for menopausal osteoporosis. Material and methods. For analysis, foreign and Russian works published in the past 15 years were sought for in the international citation system Pubmed. Results. The modern theories of the mechanism of development of menopausal osteoporosis are described. The specific features of metabolism of vitamin D and its effects on bone tissue are depicted. International and Russian guidelines for the treatment of osteoporosis are given. The data of investigations demonstrating the possibility of using active vitamin D metabolites in the therapy of menopausal osteoporosis are analyzed. Conclusion. The use of active vitamin D metabolites alone or in combination with bisphosphonates is an effective method with a good safety profile for treating women with menopausal osteoporosis.

Цель исследования. Провести систематический анализ литературных данных по проблеме терапии менопаузального остеопороза с помощью активных метаболитов витамина D. Материал и методы. С целью проведения анализа был осуществлен поиск зарубежных и отечественных публикаций в международной системе цитирования Pubmed за последние 15лет. Результаты. Описаны современные теории механизма развития менопаузального остеопороза. Описаны особенности метаболизма витамина D и его эффекты на костную ткань. Приведены международные и отечественные рекомендации по терапии остеопороза. Проанализированы данные исследований, демонстрирующих возможности применения активных метаболитов витамина D в терапии менопаузального остеопороза. Заключение. Применение активных метаболитов витамина D в виде монотерапии или в сочетании с бисфосфонатами является эффективным методом лечения женщин с менопаузальным остеопорозом с благоприятным профилем безопасности.

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