Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media33603210.18565/aig.2022.293ReviewsОбзорыReview ArticlePotentials of the current pharmacotherapy of endometriosisВозможности современной фармакотерапии эндометриозаhttps://orcid.org/0000-0001-7286-6047DumanovskayaMadina R.ДумановскаяМадина Равилевна
Russian Federation

PhD, Researcher, Gynecological Endocrinology Department

к.м.н., н.с. отделения гинекологической эндокринологии

m_dumanovskaya@oparina4.ruhttps://orcid.org/0000-0003-1498-6520TabeevaGuzal I.ТабееваГюзяль Искандеровна
Russian Federation

PhD, Senior Researcher, Gynecological Endocrinology Department

к.м.н., с.н.с. отделения гинекологической эндокринологии

g_tabeeva@oparina4.ruIvannikovaJulia A.ИванниковаЮлия Алексеевна
Russian Federation

physician, resident

врач, ординатор

ivannikova0@yandex.ruhttps://orcid.org/0000-0003-4768-115XSolopovaAlina E.СолоповаАлина Евгеньевна
Russian Federation

Dr. Med. Sci., Associate Professor, Leading Researcher, Department of Radiology

д.м.н., в.н.с. отделения лучевой диагностики отдела визуальной диагностики

a_solopova@oparina4.ruhttps://orcid.org/0000-0001-8739-5209AsaturovaAleksandra V.АсатуроваАлександра Вячеславовна
Russian Federation

Dr. Med. Sci., Head of 1st Pathology Department

д.м.н., заведующая 1-м патологоанатомическим отделением

a_asaturova@oparina4.ruhttps://orcid.org/0000-0002-0627-3902SmetnikAntonina A.СметникАнтонина Александровна
Russian Federation

PhD, Head of the Department of Gynecological Endocrinology

к.м.н., заведующая отделением гинекологической эндокринологии

a_smetnik@oparina4.ruAlievaPatimat M.АлиеваПатимат Магомедовна
Russian Federation

obstetrician-gynecologist, postgraduate student at the Department of Gynecological Endocrinology

врач акушер-гинеколог, аспирант отделения гинекологической эндокринологии

patimat.alieva.1997@bk.ruhttps://orcid.org/0000-0002-6629-051XErmakovaElena I.ЕрмаковаЕлена Ивановна
Russian Federation

PhD, Senior Researcher at the Department of Gynecological Endocrinology

к.м.н., с.н.с. отделения гинекологической эндокринологии

e_ermakova@oparina4.ruhttps://orcid.org/0000-0002-1313-7079PavlovichStanislav V.ПавловичСтанислав Владиславович
Russian Federation

Ph.D., Academic Secretary; Professor, Department of Obstetrics, Gynecology, Perinatology and Reproductology

к.м.н., ученый секретарь; профессор кафедры акушерства, гинекологии, перинатологии и репродуктологии ИПО

s_pavlovich@oparina4.ruAcademician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени В.И. Кулакова» Минздрава РоссииI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)18042023238451604202316042023Copyright ©; 2023, Bionika MediaCopyright ©; 2023, ООО «Бионика Медиа»2023Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/336032

Endometriosis is a chronic polyetiological disease characterized by the presence of endometrial-like tissue outside the uterine cavity. The known symptoms of endometriosis include the following: dysmenorrhea, dyspareunia, dysuria, dyschezia, chronic pelvic pain, and infertility. Postoperative endometriosis recurrences are known to occur in approximately 50% of patients within 5 years in the absence of postoperative suppressive treatment. The paper describes different groups of drugs (gonadotropin-releasing hormone agonists and antagonists, progestogens, combined hormonal contraceptives, dopamine agonists, and metformin) for the treatment of endometriosis, their mechanism of action, and their efficacy in relieving chronic pelvic pain, preventing endometriosis recurrences, side effects, and the impact on quality of life.

Conclusion: Taking into account the chronic nature of the disease, today it is important to find effective drugs with a minimum number of side effects, which will relieve pain syndrome and reduce the frequency of surgical re-interventions and endometriosis relapses.

Эндометриоз – это хроническое полиэтиологичное заболевание, характеризующееся наличием ткани, подобной эндометрию, вне полости матки. Симптомы эндометриоза известны: дисменорея, диспареуния, дизурия, дисхезия, хроническая тазовая боль и бесплодие. Известно, что рецидивы эндометриоза после хирургического вмешательства происходят примерно у 50% пациенток в течение 5 лет при отсутствии послеоперационного супрессивного лечения. В статье описаны различные группы препаратов для лечения эндометриоза (агонисты и антагонисты гонадотропин-рилизинг-гормона, прогестагены, комбинированные гормональные контрацептивы, агонисты дофамина, метформин), механизм их действия, эффективность в купировании хронической тазовой боли, профилактике рецидивов эндометриоза, побочные действия, влияние на качество жизни.

Заключение: Принимая во внимание хронический характер заболевания, на сегодняшний день важным является поиск эффективных лекарственных средств с минимальным количеством побочных эффектов, которые позволят купировать болевой синдром, снизить частоту повторных оперативных вмешательств и рецидивов эндометриоза.

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