Obstetrics and GynecologyObstetrics and GynecologyАкушерство и гинекология0300-90922412-5679Bionika Media62295510.18565/aig.2023.212ReviewsОбзорыReview ArticleSpectrum of significant serum biomolecules and genetic predictors in antenatal diagnosis of placenta accreta spectrumСпектр значимых сывороточных биомолекул и генетических предикторов в антенатальной диагностике патологической инвазии плацентыhttps://orcid.org/0000-0003-2685-4285KayumovaAlena V.КаюмоваАлена Владимировна
Russian Federation

PhD, Leading Researcher, Deputy Chief Physician for Quality Control and Safety of Medical Activities, Ural Research Institute of Maternity and Child Care, Ministry of Health of the Russian Federation

к.м.н., в.н.с., заместитель главного врача по контролю качества и безопасности медицинской деятельности, НИИ ОММ Минздрава России

kaum-doc@mail.ruhttps://orcid.org/0000-0002-4090-0578MelkozerovaOksana A.МелкозероваОксана Александровна
Russian Federation

Dr. Med. Sci., Deputy Director for Science, Ural Research Institute of Maternity and Child Care, Ministry of Health of the Russian Federation

д.м.н., заместитель директора по научной работе, НИИ ОММ Минздрава России

abolmed1@mail.ruhttps://orcid.org/0000-0001-5746-316XBashmakovaNadezhda V.БашмаковаНадежда Васильевна
Russian Federation

Dr. Med. Sci., Professor, Chief Researcher, Ural Research Institute of Maternity and Child Care, Ministry of Health of the Russian Federation

д.м.н., профессор, Главный н.с., НИИ ОММ Минздрава России

bashmakovanv@niiomm.ruhttps://orcid.org/0000-0002-5500-6296MalginaGalina B.МальгинаГалина Борисовна
Russian Federation

Dr. Med. Sci., Professor, Director, Ural Research Institute of Maternity and Child Care, Ministry of Health of the Russian Federation

д.м.н., профессор, директор, НИИ ОММ Минздрава России

galinamalgina@mail.ruhttps://orcid.org/0000-0002-0852-6766ChistyakovaGuzal N.ЧистяковаГузель Нуховна
Russian Federation

Dr. Med. Sci., Professor, Head of Research Department of Immunology and Microbiology, Ural Research Institute of Maternity and Child Care, Ministry of Health of the Russian Federation

д.м.н., профессор, руководитель научного отделения иммунологии и микробиологии, НИИ ОММ Минздрава России

guzel@niiomm.ruhttps://orcid.org/0000-0002-5715-7514TretyakovaTatyana B.ТретьяковаТатьяна Борисовна
Russian Federation

PhD, Associate Professor, Senior Researcher at the Genetic Research Group of the Department of Biochemical Research Methods, Laboratory Geneticist, Ural Research Institute of Maternity and Child Care, Ministry of Health of the Russian Federation

к.м.н., доцент, с.н.с. группы генетических исследований отделения биохимических методов исследования, врач лабораторный генетик, НИИ ОММ Минздрава России

TBTretyakova@yandex.ruhttps://orcid.org/0000-0001-7433-2217GrishkinaAnastasia A.ГришкинаАнастасия Александровна
Russian Federation

PhD, Senior Researcher, Department of Immunology, Clinical Microbiology, Pathomorphology and Cytodiagnosis, Pathologist, Ural Research Institute of Maternity and Child Care, Ministry of Health of the Russian Federation

к.м.н., с.н.с. отделения иммунологии, клинической микробиологии, патоморфологии и цитодиагностики, врач-патологоанатом, НИИ ОММ Минздрава России

xumukyc.ru@mail.ruUrals Scientific Research Institute for Maternal and Child Care, Ministry of Health of RussiaФГБУ «Уральский научно-исследовательский институт охраны материнства и младенчества» Министерства здравоохранения Российской Федерации30122023125150311202303112023Copyright ©; 2023, Bionika MediaCopyright ©; 2023, ООО «Бионика Медиа»2023Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/0300-9092/article/view/622955

Background: Placenta accreta spectrum (PAS) poses a serious threat to the life of the mother and fetus. Untimely diagnosis of PAS resulting in delayed treatment may be one of the key causes of serious adverse pregnancy outcomes. Recent studies have increasingly focused attention on various biomolecules that have the potential to diagnose PAS in due time.

Objective: To compare the effectiveness of various molecular biological markers in the antenatal diagnosis of abnormally invasive placenta.

Materials and methods: The analysis of the Russian and foreign research literature databases, namely eLibrary, Medline, PubMed, Embase, Crossref, RSCI, was carried out with the keywords “abnormally invasive placenta”, “placenta accreta spectrum”, “biomarkers”, “antenatal diagnosis”, “epithelial-mesenchymal transition”, “biomolecules”. According to the above goal, 68 literature sources were selected for the analysis.

Results: The significant biomarkers of abnormally invasive placenta and their dynamic change at different gestation periods were described and compared in this review. Biomolecules involved in the pathogenesis of abnormally invasive placenta can be conventionally divided into several groups. These are growth factors, interleukins, signaling molecules, oxidative stress products, microRNA, DNA, and circulating cells. Their content in biological fluids and placenta reflects the activity of pathophysiological processes involved in the formation of abnormally invasive placenta.

Conclusion: Studying the spectrum and concentration of biomarkers of abnormally invasive placenta can contribute to the antenatal confirmation of the diagnosis and severity of this pathology and it can be crucial for improving maternal and perinatal outcomes.

Актуальность: Патологическая инвазия плаценты (PAS) представляет серьезную опасность для жизни матери и плода. Несвоевременная диагностика PAS и возникающая в результате задержка в лечении может быть одной из ключевых причин серьезных неблагоприятных исходов беременности. В последних публикациях все больше внимания уделяется различным биомолекулам, которые обладают потенциалом для своевременной диагностики PAS.

Цель: Сравнительная оценка эффективности использования различных молекулярно-биологических маркеров в антенатальной диагностике патологической инвазии плаценты.

Материалы и методы: По ключевым словам «патологическая инвазия плаценты», «врастание плаценты», «placenta accreta spectrum», «биомаркеры», «антенатальная диагностика», «эпителиально-мезенхимальный переход», «биомолекулы» проведен анализ отечественных и зарубежных литературных баз данных: eLibrary, Medline, PubMed, Embase, Crossref, РИНЦ. В соответствии с поставленной целью было отобрано для анализа 68 источников литературы.

Результаты: Результатом поиска явилось сравнительное описание представленных в данном обзоре значимых биомаркеров патологической инвазии плаценты и их динамическое изменение в различные сроки гестации.

Биомолекулы, участвующие в патогенезе патологической инвазии плаценты, условно можно разделить на несколько групп. Это факторы роста, интерлейкины, сигнальные молекулы, продукты оксидативного стресса, микро-РНК, ДНК, циркулирующие клетки. Их содержание в биологических жидкостях и плаценте отражает активность патофизиологических процессов, участвующих в формировании патологической инвазии плаценты.

Заключение: Исследование спектра и концентрации биомаркеров патологической инвазии плаценты может способствовать антенатальному подтверждению диагноза и степени тяжести данной патологии и иметь решающее значение для улучшения материнских и перинатальных исходов.

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