The clinical and hormonal features of hyperprolactinemia in the formation of the reproductive system in girls

One hundred and thirty-four patients aged 12 to 18 years with various menstrual dysfunctions and verified hyperprolactinemia were examined. Group 1 included 17 girls with proven pituitary microadenoma and drastically increased prolactin secretion; Group 2 comprised 117 girls with moderate hyperprolactinemia without organic pituitary changes. The clinical picture of hyperprolactinemia was more evident in Group 1. Most patients were observed to have amenorrhea, galactorrhea, and internal genital hypoplasia. Impairments were characterized by polymorphism and were less pronounced in Group 2 patients. Oligomenorrhea (64.9%), abnormal hair growth of various intensity (61.5%), and ovarian polycystosis (50.7%) were most common in this group. Fifty-five of the 134 patients were found to have clinical manifestations of the pubertal hypothalamic syndrome. Examining the secretion of prolactin, gonadotropins, and estradiol revealed considerable shifts in hypothalamic-pituitary-ovarian relationships. An inverse proportional relationship was established between the levels of secretion of prolactin, gonadotropin, and estradiol. The found high incidence of hyperprolactinemia without manifest symptoms (galactorrhea-amenorrhea) characteristic of the hyperprolactinemia syndrome shows it expedient to determine the level of prolactin in all cases of impaired formation of the reproductive system, in dysmenorrhea in particular.

hyperprolactinemia, puberty, follicle-stimulating hormone, luteinizing hormone