ROLE OF MANNOSE-BINDING LECTIN IN THE DEVELOPMENT OF PREECLAMPSIA

Objective. To define the role of MBL2 codon 34 polymorphism in the development of gestosis. Subjects and method. A study group included 78 patients with gestosis and 77 women with physiological pregnancy formed a control group. The diagnosis of gestosis was made according to the Goecke scale modified by G.M. Savelyeva. MBL2 codon 34 polymorphism was analyzed using polymerase chain reaction/restriction. Results. In our study, homozygotes for allele A were significantly less common in the women with gestosis than those in the controls (59 and 76.6%, respectively;p=0.0252). The variant allele was associated with the development of gestosis (26.9 and 15.6 % in the study and control groups, respectively; p=0.0181), which was also confirmed by comparing the frequency of hetero- and homozygous variant alleles (AB+BB) in the women with gestosis and in the control group (41 and 23.4%, respectively, p=0.00252). Conclusion: The maternal carriage of the mutant MBL allele may lead to reduced MBL levels and hence to inadequate utilization of trophoblast fragments, to increased tumor necrosis factor production, by giving rise to a systemic inflammatory response and endothelial dysfunction.

gestosis, mannose-binding lectin, innate immunity, single-nucleotide polymorphism