ROLE OF REGULATORY T CELLS IN THE DEVELOPMENT OF IMMUNE TOLERANCE IN PREGNANCY


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Abstract

The review gives an update on the role of regulatory T cells in the development and maintenance of immune tolerance that is necessary to the physiological development of pregnancy. It considers immune dysregulation in pregnancy complications and describes the possibility of using regulatory T cells to correct gestation.

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About the authors

E. O STEPANOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: elena2404.07@mail.ru

M. A NIKOLAYEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nikolaeva_ma@mail.ru

A. A BABAYAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: alinababayan@yandex.ru

V. Yu SMOLNIKOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_smolnikova@oparina4.ru

L. V VANKO

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: LVanko@oparina4.ru

L. V KRECHETOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: l_krechetova@oparina4.ru

References

  1. Billingham R.E., Brent L., Medawar P.B. Actively acquired tolerance of foreign cells. Nature. 1953; 172(4379): 603-6; J. Immunol. 2010; 184(1): 5—8.
  2. Gershon R.K., Cohen P., Hencin R., Liebhaber S.A. Suppressor T cells. J. Immunol. 1972: 108: 586—90.
  3. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25): breakdown of a single mechanism of self-tolerance causes various immune diseases. J. Immunol. 1995; 155(3): 1151—64.
  4. Guerin L.R., Prins J.R., Robertson S.A. Regulatory T-cell and immune tolerance in pregnancy: a new target for infertility treatment? Hum. Reprod. Update. 2009; 15(5): 517—35.
  5. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003; 299(5609): 1057—61.
  6. Peterson R.A. Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression. Toxicol. Pathol. 2012; 40(2): 186—204.
  7. Yu N., Li X., Song W., Li D., Yu D., Zeng X. et al. СD4(+)CD25(+) CD127(low/-) T cells: a more specific Treg population in human peripheral blood. Inflammation. 2012; 35(6): 1773—80.
  8. Bacchetta R., Sartirana C., Levings M.K., Bordignon C., Narula S., Roncarolo M.G. Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines. Eur. J. Immunol. 2002; 32: 2237—45.
  9. Carrier Y., Yuan J., Kuchroo V.K., Weiner H.L. Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice. J. Immunol. 2007; 178(1): 179—85.
  10. Chaturvedi V., Collison L.W., Guy C.S., Workman C.J., Vignali D.A. Human regulatory T cells require interleukin-35 to mediate suppression and infectious tolerance. J. Immunol. 2011; 186(12): 6661—66.
  11. Wilczynscki J.R., Radwan M., Kalinka J. The characterization and role of regulatory T cells in immune reactions. Front. Biosci. 2008; 13: 2266 —74.
  12. Vignali D.A., Collison L.W., Workman C.J. How regulatory T cells work. Nat. Rev. Immunol. 2008; 8: 523—32.
  13. Zenclussen M.L., Thuere C., Ahmad N., Wafula P.O., Fest S., Zenclussen A.C. et al. The persistence of paternal antigens in the maternal body is involved in regulatory T-cell expansion and fetal-maternal tolerance in murine pregnancy. Am. J. Reprod. Immunol. 2010; 63(3): 200—8.
  14. Issazadeh-Navikas S., Teimer R., Bockermann R. Influence of dietary components on regulatory T cells. Mol. Med. 2012; 18(1): 95—110.
  15. Zenclussen A.C., Gerlof K., Zenclussen M.L., Sollwedel A., Bertoja A.Z., Ritter T. et al. Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model. Am. J. Pathol. 2005; 166: 811—22.
  16. Thuere C., Zenclussen M.L., Schumacher A., Langwisch S., Schulte-Wrede U., Zenclussen A.C. et al. Kinetics of regulatory T cells during murine pregnancy. Am. J. Reprod. Immunol. 2007; 58: 514—23.
  17. Dimova T., Nagaeva O., Stenqvist A.C., Hedlund M., Kjellberg L., Mincheva-Nilsson L. et al. Maternal Foxp3 expressing CD4+ CD25+ and CD4+ CD25- regulatory T-cell populations are enriched in human early normal pregnancy decidua: a phenotypic study of paired decidual and peripheral blood samples. Am. J. Reprod. Immunol. 2011; 66(1): 44—56.
  18. Winger E.E., Reed J.L. Low circulating CD4+CD25+Foxp3+ T regulatory cell levels predict miscarriage risk in newly pregnant women with a history of failure. Am. J. Reprod. Immunol. 2011; 66(4): 320—8.
  19. Leber A., Teles A., Zenclussen A.C. Regulatory T cells and their role in pregnancy. Am. J. Reprod. Immunol. 2010; 63: 445—59.
  20. Arruvito L., Sanz M., Banham A.H., Fainboim L. Expansion of CD4+CD25+and FOXP3+ regulatory T cells during the follicular phase of the menstrual cycle: implications for human reproduction. J. Immunol. 2007; 178: 2572—78.
  21. Kallikourdis M., Andersen K.G., Welch K.A., Betz A.G. Alloantigen enhanced accumulation of CCR5+ ‘effector’ regulatory T cells in the gravid uterus. Proc. Natl. Acad. Sci. USA. 2007; 104: 594—99.
  22. Robertson S.A., Guerin L.R., Bromfield J.J., Branson K.M., Ahlstrom A.C., Care A.S. Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biol. Reprod. 2009; 80: 1036—45.
  23. Samstein R.M., Josefowicz S.Z., Arvey A., Treuting P.M., Rudensky A.Y. Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell. 2012; 150(1): 29—38.
  24. Williams Z. Inducing tolerance to pregnancy. N. Engl. J. Med. 2012; 376(12): 1159—61.
  25. Бабаян А.А., Смольникова В.Ю., Николаева М.А., Степанова Е.О., Калинина Е.А. Влияние иммунорегуляторных свойств семенной плазмы на репродуктивную функцию женщин. Гинекология. 2012; 14: 80—2.
  26. Robertson S.A., Guerin L.R., Moldenhauer L.M., Hayball J.D. Activating T regulatory cells for tolerance in early pregnancy -the contribution of seminal fluid. J. Reprod. Immunol. 2009; 83(1—2): 109—16.
  27. Mold J.E., Michaёlsson J., Burt T.D., Muench M.O., Beckerman K.P., Busch M.P. et al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science. 2008; 322(5907): 1562—65.
  28. Gorczynski R., Khatri I., Lee L., Boudakov I. An interaction between CD200 and monoclonal antibody agonists to CD200R2 in development of dendritic cells that preferentially induce populations of CD4+CD25+ T regulatory cells. J. Immunol. 2008; 180(9): 5946—55.
  29. Lee S.K., Kim J.Y., Hur S.E., Kim C.J., Na B.J., Lee M. et al. An imbalance in interleukin-17-producing T and Foxp3+ regulatory T cells in women with idiopathic recurrent pregnancy loss. Hum. Reprod. 2011; 26(11): 2964—71.
  30. Liu Y.S., Wu L., Tong X.H., Wu L.M., He G.P., Luan H.B. et al. Study on the relationship between Th17 cells and unexplained recurrent spontaneous abortion. Am J Reprod Immunol. 2011; 65(5): 503—11.
  31. Charding S.R., Egan P.J. γδ T-cells: functional plasticity and heterogeneity. Nat. Rev. Immunol. 2002; 2: 336—45.
  32. Mincheva-Nilsson L., Kling M., Hammarström S., Nagaeva O., Sundqvist K.G., Baranov V. et al. Gamma delta T-cells of human early pregnancy decidua: evidence for local proliferation, phenotypic heterogeneity, and extrathymic differentiation. J. Immunol. 1997; 159(7): 3266—77.
  33. Szekeres-Bartho J., Barakonyi A., Miko E., Polgar B., Palkovics T. The role of γδ T-cells in the feto-maternal relationship. Semin. Immunol. 2001; 13: 229—33.
  34. Mincheva-Nilsson L., Nagaeva O., Sundqvist K.G., Hammarstrom M.L., Hammarstrom S., Baranov V γδ T-cells of early pregnancy deciduas evidence for cytotoxic potency. Int. Immunol. 2000; 12: 585—96.
  35. Salmonsen L.A., Dimitriadis E., Robb L. Cytokines in implantation. Semin. Reprod. Med. 2000; 18: 299—310.
  36. Szereday L., Barakonyi A., Miko E., Varga P., Szekeres-Bartho J. γδ T-cell subsets, NKG2A expression and apoptosis of Vδ2+ T-cells in pregnant women with or without risk of premature pregnancy termination. Am. J. Reprod. Immunol. 2003; 50: 490—6.
  37. Suzuki T., Hiromatsu K., Ando Y., Okamoto T., Tomoda Y., Yoshikai Y. Regulatory role of gamma delta T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response. J. Immunol. 1995; 154(9): 4476—84.
  38. Nikahava H., Kato T., Tawara I., Ikeda H., Kuribayashi K., Shiky H. et al. IFN-y controls the generation/activation of CD4+CD25+ regulatory T cell in antitumor immune response. J. Immunol. 2005; 175: 4433—40.
  39. Rocken M., Shevach E.M. Immune deviation — the third dimension of nondeletional T cell tolerance. Immunol. Rev. 1996; 149: 175 —94.
  40. Opelz G., Senger D.P.S., Mickey M.R., Terasaki P.I. Effect of blood transfusion on subsequent kidney transplants. Transplant. Proc. 1973; 5: 253—59.
  41. Говалло В.И., Сидельникова В.М. Иммунизация беременных женщин аллогенными лимфоцитами мужа как метод профилактики самопроизвольных выкидышей. Акушерство и гинекология. 1983; 12: 25—7.
  42. Голубева Е.Л., Матвеева Н.К., Кречетова Л.В., Зиганшина М.М., Петросян Л.А. Подготовка к беременности женщин с привычным невынашиванием ранних сроков с использованием различных доз аллогенных лимфоцитов. Акушерство и гинекология. 2009; 6: 17—20.
  43. Yang H., Qiu L., Di W., Zhao A., Chen G., Hu K., Lin Q. Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients. Fertil. Steril. 2009; 92(1): 301—5.
  44. Bettini M., Vignali D.A. Regulatory T cells and inhibitory cytokines in autoimmunity. Curr. Opin. Immunol. 2009; 21(6): 612—8.
  45. Liang P., Mo M., Li G.G., Yin B., Cai J., Wu T. et al. Comprehensive analysis of peripheral blood lymphocytes in 76 women with recurrent miscarriage before and after lymphocyte immunotherapy. Am. J. Reprod. Immunol. 2012; 68(2): 164—74.
  46. Worldwide collaborative observational study and meta-analysis on allogenic leukocyte immunotherapy for recurrent spontaneous abortion. Recurrent Miscarriage Immunotherapy Trialists Group. Am. J. Reprod. Immunol. 1994; 32(2): 55—72.
  47. Clark D.A. Immunological factors in pregnancy wastage: fact or fiction. Am. J. Reprod. Immunol. 2008; 59(4): 277—300.
  48. Mandapathil M., Lang S., Gorelik E., Whiteside T.L. Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression. J. Immunol. Methods. 2009; 346: 55—63.
  49. Yin Y., Han X., Shi Q., Zhao Y., He Y. Adoptive transfer of CD4+CD25+ regulatory T cells for prevention and treatment of spontaneous abortion. Eur. J. Obstet. Gynecol. Reprod. Biol. 2012; 161(2): 177—81.
  50. Muller Y.D., Seebach J.D., Bühler L.H., Pascual M., Golshayan D. Transplantation tolerance: Clinical potential of regulatory T cells. Self Nonself. 2011; 2(1): 26—34.

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