Prediction of fetal growth retardation in pregnant women with undifferentiated connective tissue dysplasia
- Authors: Kan N.E.1, Amiraslanov E.Y.1, Tyutyunnik V.L.1, Donnikov A.E.1, Tyutyunnik N.V.1
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Affiliations:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Issue: No 10 (2014)
- Pages: 22-26
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247243
- ID: 247243
Cite item
Open Access
Access granted
Abstract
Objective. To create a mathematical model for the prediction of fetal growth retardation in patients with undifferentiated connective tissue dysplasia (USTD). Subject and methods. A prospective cohort study was conducted in 201 pregnant women. According to the Fenton percentile growth chart, all the patients were divided into two groups. A study group consisted of 63 women whose babies were rated to be in the 3 rd to 10 lh percentiles. A comparison group included 138 patients whose babies were assigned to the 10 th or more percentile range. The magnitude of dysplasia was determined by the modified growth chart. Results. The investigators determined the clinical and molecular genetic predictors of fetal growth retardation, such as the magnitude of USTD, threatened miscarriage in the second trimester, an exacerbation of chronic urinary tract diseases, and threatened preterm labor during ultrasound study, as well as VEGFA gene polymorphisms: -634 G>C and VEGFA: 936 C>T. Conclusion. A mathematical model including the clinical anamnestic and molecular genetic parameters was developed to predict fetal growth retardation in patients with USTD.
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About the authors
Natalya E. Kan
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: n_kan@oparina4.ru
PhD, MD, the chief physician
Elrad Y. Amiraslanov
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: e_amiraslanov@oparina4.ru
scientific researcher, collaborator of the obstetric observation department
Victor L. Tyutyunnik
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: tioutiounnik@mail.ru
PhD, MD, the head of the obstetric observation department
Andrey E. Donnikov
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: a_donnikov@oparina4.ru
MD, senior scientific researcher, laboratory of molecular genetics, A
Nataliya V. Tyutyunnik
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: tysia07@bk.ru
resident
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