PRO- AND ANTIOXIDANT SYSTEM IN PRETERM BIRTH


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Abstract

Objective. To investigate the role of oxidative stress and a systemic inflammatory response in preterm birth. Materials and methods. Literature sources published in the resources of Pubmed, Elibrary, and Medline were sought. A total of 150 sources dealing with the study of the pathogenesis of preterm delivery and its early diagnostic criteria were found; 37 of them were included in this review. Results. An update on the pathogenesis of preterm birth is presented by describing changes at the molecular genetic and immunological levels. Oxidative stress and a systemic inflammatory response are shown to be responsible for preterm birth. The investigation of this problem at the molecular genetic and immunological levels will be able to develop new methods for the prediction and diagnosis of preterm birth for the early prevention and treatment of this abnormality. Conclusion. Preterm birth is associated with a systemic inflammatory response. The latter is known to be accompanied by the development of oxidative stress leading to enhanced apoptotic processes and disorders at both the cellular and subcellular levels.

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About the authors

Tatiana A. Kurchakova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: t_kurchakova@oparina4.ru
postgraduate student 117997, Russia, Moscow, Ac. Oparina str. 4

Victor L. Tyutyunnik

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tioutiounnik@mail.ru
PhD, MD, the head of the obstetric physiological department 117997, Russia, Moscow, Ac. Oparina str. 4

Natalia E. Kan

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
PhD, MD, the head of the obstetric observation department 117997, Russia, Moscow, Ac. Oparina str. 4

Marzanat K. Medzhidova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: marzana-m@yandex.ru
PhD candidate 117997, Russia, Moscow, Ac. Oparina str. 4

Elena A. Sirotkina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_sirotkina@oparina4.ru
postgraduate student 117997, Russia, Moscow, Ac. Oparina str. 4

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