MOLECULAR GENETIC PREDICTORS OF ABNORMAL UTERINE BLEEDING IN GIRLS BORN WITH INTRAUTERINE GROWTH RESTRICTION


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Abstract

Objective. To investigate associations of NOS3 and ESR1 gene polymorphisms in girls born with intrauterine growth restriction (IUGR) who suffer from abnormal uterine bleeding of puberty (AUBP). Subjects and methods. Examinations were made in 96 adolescent girls suffering from menarche in AUBP, including 32 girls born at term with IUGR, 37girls born with normal weight, and 27 healthy girls. A real-time PCR assay was used to study the single-allele polymorphisms NOS3 786T>C, 894G>T and ESR1351A>G, and 397T>C. Results. The girls suffering from AUBP born with IUGR were more often found to be carriers of the polymorphic C allele of NOS3 786T>C (OR = 2.03; 95% CI, 1.12-3.68 for homozygotes; p = 0.04; OR = 1.68; 95% CI, 1.09-2.60;p = 0.046for heterozygotes) and ESR1 Pvull CCgenotype (OR = 4. 58; 95% CI, 0.97-21.68;p = 0.04). Conclusion. Intrauterinally programmable endothelial dysfunction syndrome may be of importance in developing AUBP in girls born with IUGR.

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About the authors

Oxana Alexandrovna Melkozerova

Email: abolmed1@mail.ru
PhD, Head of department reproductive function preservation, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia 620028, Russia, Ekaterinburg, Repin str. 1

Nadezda Vasilievna Bashmakova

Email: dr@niiomm.ru
MD, Prof., Director of Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia. 620028, Russia, Ekaterinburg, Repin str. 1

Tatyana Borisovna Tretyakova

Email: TBTretyakova@yandex.ru
geneticist, PhD, head of the Genetics Laboratory, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia. 620028, Russia, Ekaterinburg, Repin str. 1

Ekaterina Vadimovna Volkova

Email: volkovakatay@mail.ru
obstetrician-gynecologist, post-graduate, department reproductive function preservation, Ural Research Institute of Maternity and Child Care, Ministry of Health of Russia 620028, Russia, Ekaterinburg, Repin str. 1

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