The course and outcomes of pregnancy in women with idiopathic recurrent miscarriage during immunocytic therapy


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Abstract

Pregravid preparation that can be done by different methods occupies a special place in the treatment of idiopathic recurrent miscarriage (RM). Objective. To assess the course and outcomes of pregnancies in women with idiopathic RM, whose pregravid preparation included immunocytic therapy (ICT). Subjects and methods. The investigation enrolled 127 women with RM. The pregravid preparation encompassed ICT as monotherapy (Group 1, n = 45) and that in combination with dydrogesterone (Group 2; n = 39). Group 3 (n = 23) consisted of women who received no pregravid preparation. Results. The investigation showed that the course of pregnancy was characterized by significantly fewer complications in women undergoing pregravid preparation. Preterm labor was more common in Group 3. The course and outcome of pregnancy did not differ in the groups of women receiving different types of pregravid preparation. Conclusion. The findings make it possible to recommend that ICT should be included in a pregravid preparation program for married couples with idiopathic RM.

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About the authors

Victoria A. Saribegova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: saribegova_v@rambler.ru
Graduate student, Department of Pregnancy Loss Prevention and Therapy

Nana K. Tetruashvili

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tetrauly@mail.ru
Doctor of Medicine, Head of the Department of Pregnancy Loss Prevention and Therapy

Lyubov V. Krechetova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: k_l_v_@mail.ru
Ph.D. in medical sciences, Head of Laboratory of Clinical Immunology

Anna Aramovna Agadzhanova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: aagadjanova@mail.ru
Doctor of Medicine, Doctor of Department of Pregnancy Loss Prevention and Therapy

Valentina V. Vtorushina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: vtorushina@inbox.ru
Ph.D. in medical sciences, doctor of laboratory diagnostics in Laboratory of Clinical Immunology

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