Granulosa cells as sources of reactive oxygen species


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Abstract

Objective. To summarize the data available in the literature on the sources of reactive oxygen species in the granulosa cells and their physiological and pathophysiological significance for the female reproductive system. Material and methods. Publications from the PubMed database were used to make this review. Results. The review considers in detail the prooxidant and antioxidant components of free radical homeostasis in the granulosa cells. It gives data on the impact of the oxidative status of granulosa on the success of an in vitro fertilization procedure. Conclusion. Free radicals produced by granulosa cells play a dual role in ovarian homeostasis, by simultaneously participating in intracellular cascades and exerting a damaging effect on follicle cells. The oxidative status of granulosa should be taken into account when working out new assisted reproductive technology programs.

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About the authors

Maja A. Shestakova

Pirogov Russian National Research Medical University

Email: chrysolite7@gmail.com
student

Elena V. Proskurnina

Lomonosov Moscow State University

Email: proskurnina@gmail.com
PhD, associate professor of the Department of Medical Biophysics, Faculty of Fundamental Medicine

Liya N. Shcherbakova

Lomonosov Moscow State University

Email: liya.fbm@gmail.com
PhD, associate professor of the Department of Obstetrics and Gynecology, Faculty of Fundamental Medicine

Olga B. Panina

Lomonosov Moscow State University

Email: olgapanina@yandex.ru
MD, professor, head of the Department of Obstetrics and Gynecology, Faculty of Fundamental Medicine

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