The clinical role of anatomical abnormality of the hymen

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Abstract

Hymen atresia is a congenital anomaly of the female genital organs, which occurs in 1 per 1000–2,000 newborn girls.

In the paper, based on the data of modern medical literature, the authors carry out a critical analysis of the theories of vaginal embryogenesis, detailed the key stages of development of the female genital system as a whole and show the relationship of formation of the urinary and genital systems. Also, based on the cases presented in the literature, they indicate that due to the nonspecific symptoms, the detection of hymen atresia is often delayed, which leads not only to female reproductive dysfunction, but also to cardiovascular, urinary, nervous, digestive, and locomotor complications, and to unjustified surgical interventions.

Conclusion: In this connection, the authors believe that for the timely diagnosis of hymen atresia, concomitant anomalies, and complications, for the prevention of unjustified surgical interventions, it is important that practitioners should have a certain clinical alertness and a clear idea of different types of symptomatic manifestations of this congenital malformation.

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About the authors

Vladimir Ye. Milyukov

Department of Human Anatomy, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

Email: Milyucov@mail.ru
ORCID iD: 0000-0002-8552-6727

Dr. Med. Sci., Professor

Russian Federation, Moscow

Elizaveta A. Brileva

I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)

Author for correspondence.
Email: lbrileva.brilli@gmail.com
ORCID iD: 0000-0002-8343-751X

student of the N.V. Sklifosovsky Institute of Clinical Medicine

Russian Federation, Moscow

Diana R. Zakirova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)

Email: Elmira.z.ufa@yandex.ru
ORCID iD: 0000-0002-5918-5789

student of the N.V. Sklifosovsky Institute of Clinical Medicine

Russian Federation, Moscow

Nguyen Cao Cuong

Yersin University

Email: nguyencaocuong2712@gmail.com
ORCID iD: 0000-0003-2190-6648

PhD, Dean of the Faculty of Pharmacy and Nursing

Viet Nam, Da Lat

References

  1. Amponsah-Manu F., Ssentongo P., Arkorful T., Ofosu-Akromah R., Ssentongo A.E., Hansen-Garshong S. et al. Imperforate hymen and leaking hematosalpinx mimicking acute appendicitis: A report of a rare case and a review of literature. Int. J. Surg. Case Rep. 2019; 63: 69-74. https://dx.doi.org/10.1016/ j.ijscr.2019.09.003.
  2. Acar A., Ercan F., Balci O., Elçi Atılgan A., Alan C., Niftiyev K. Long-term results of an imperforate hymen procedure that leaves the hymen intact. J. Obstet. Gynaecol. India. 2022; 71(2): 168-72. https://dx.doi.org/10.1007/ s13224-020-01407-4.
  3. Bonello K., Tlili Y., Ben Zeid O., Figoni H., Mazeghrane M. Haematocolpos due to imperforate hymen disguised as constipation. J. Paediatr. Child Health. 2021; 57(5): 715-7. https://dx.doi.org/10.1111/jpc.14931.
  4. Veiga V.F., Ribeiro B., Afonso H., Reis I. Pelvic pain in young girls: not only dysmenorrhoea! BMJ Case Rep. 2018; 2018: bcr2018226041. http://dx.doi.org/10.1136/bcr-2018-226041.
  5. Palacios-Acosta J.M., León-Hernández A., Shalkow-Klincovstein J., Córdova-Ortega J., Rangel-Quintana C. Hematocolpos por himen imperforado: errores en su diagnóstico y abordaje. Acta Pediatr. Mex. 2011; 32(6): 323-31.
  6. Salö M., Börjesson A. Hymen imperforatus är en diagnos som ofta missas. Läkartidningen. 2017; 114: ECLT.
  7. Enes P., Brandão P., Ramôa P., Torgal A. Imperforate hymen: the importance of early diagnosis. Int. J. Contracept. Obstet. Gynecol. 2017; 6(6): 2628-30. https://dx.doi.org/10.18203/2320-1770.ijrcog20172367.
  8. Wang Y.F., Kuo S.M., Lin Y.C., Fang H.H., Chu C.H., Lin C.M. Mimics of malignancy caused by concurrent imperforate hymen and transverse vaginal septum: an instructive case and review of the literature. J. Int. Med. Res. 2021; 49(5): 3000605211014797. https://dx.doi.org/10.1177/03000605211014797.
  9. Kumar Y., Yadav P., Agarwal A. Abdominal swelling and obstructive uropathy due to hematometrocolpos secondary to imperforate hymen: a case report. Pan Afrr. Med. J. 2022; 41: 18. https://dx.doi.org/10.11604/ pamj.2022.41. 832582.
  10. Karteris E., Foster H., Karamouti M., Goumenou A. Congenital imperforate hymen with hydrocolpos and hydronephrosis associated with severe hydramnios and increase of maternal ovarian steroidogenic enzymes. J. Pediatr. Adolesc. Gynecol. 2010; 23(3): 136-41. https://dx.doi.org/10.1016/ j.jpag.2009.10.002.
  11. Шидаков И.Х., Калниязов Б.М. Гидрометрокольпос у новорожденного. Российский вестник детской хирургии, анестезиологии и реаниматологии. 2019; 9(4): 88-93. [Shidakov I.Kh., Kalniyazov B.M. Hydrometrocolpos in a newborn. Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care. 2019; 9(4): 88-93. (in Russian)]. https://dx.doi.org/10.30946/2219-4061-2019-9-4-88-93.
  12. Ercan C.M., Karasahin K.E., Alanbay I., Ulubay M., Baser I. Imperforate hymen causing hematocolpos and acute urinary retention in an adolescent girl. Taiwan. J. Obstet. Ggynecol. 2011; 50(1): 118-20. https://dx.doi.org/10.1016/ j.tjog.2011.01.005.
  13. Ramareddy R.S., Kumar A., Alladi A. Imperforate hymen: varied presentation, new associations, and management. J. Indian Assoc. Pediatr. Surg. 2017; 22(4): 207-10. https://dx.doi.org/10.4103/0971-9261.214451.
  14. Lee K.H., Hong J.S., Jung H.J., Jeong H.K., Moon S.J., Park W.H. et al. Imperforate hymen: a comprehensive systematic review. J. Clin. Med. 2019; 8(1): 56. https://dx.doi.org/10.3390/jcm8010056.
  15. Баран Н.М., Адамян Л.В., Богданова Е.А., Глыбина Т.М. Клиника, диагностика и лечение атрезии девственной плевы у девочек. Акушерство и гинекология. 2014; 2: 86-90. [Baran N.M., Adamyan L.V., Bogdanova E.A., Glybina T.M. The clinical presentation, diagnosis, and treatment of atresia of the hymen in girls. Obstetrics and Gynecology. 2014; (2): 86-90. (in Rusian)].
  16. Jang E., So K.A., Kim B., Lee A.J., Kim N.R., Yang E.J. et al. Delayed diagnosis of imperforate hymen with huge hematocolpometra: a case report. World J. Clin. Cases. 2021; 9(29): 8901-5. https://dx.doi.org/10.12998/wjcc.v9.i29.8901.
  17. Acién M., Acién P. Müllerian duct development. In: Farquharson R.G., Stephenson M.D., eds. Early pregnancy. 2nd ed. Cambridge: Cambridge University Press; 2017: 90-101.
  18. Журило И.П., Перунский В.П., Иващенко Т.И., Абдулин Р.Ф., Турпакова Г.Н. Гигантский мукометрокольпос у новорожденной. Здоровье ребенка. 2012; 8: 151-4. [Zhurilo I.P., Perunsky V.P., Ivaschenko T.I., Abdulin R.F., Turpakova G.N. Giant mucometrocolpos in newborn girl. Children Health. 2012; (8): 151-4. (in Russian)].
  19. Dietrich J.E., Millar D.M., Quint E.H. Obstructive reproductive tract anomalies. J. Pediatr. Adolesc. Gynecol. 2014; 27(6): 396-402. https://dx.doi.org/10.1016/ j.jpag.2014.09.001.
  20. Chouhan M., Rachhoya P. Imperforated hymen with huge abdominal mass - A rare case. Int. J. Health Sci. Res. 2016; 6(4): 546-8.
  21. Ossman A.M.E., El-Masry Y.I., El-Namoury M.M., Sarsik S.M. Spontaneous reformation of imperforate hymen after repeated hymenectomy. J. Pediatr. Adolesc. Gynecol. 2016; 29(5): e63-5. https://dx.doi.org/10.1016/ j.jpag.2016.02.001.
  22. Coppola L. Unique case of imperforate hymen. J. Pediatr. Adolesc. Gynecol. 2016; 29(1): e1-e3. https://dx.doi.org/10.1016/j.jpag.2015.07.004.
  23. Segal T.R., Fried W.B., Krim E.Y., Parikh D., Rosenfeld D.L. Treatment of microperforate hymen with serial dilation: a novel approach. J. Pediatr. Adolesc. Gynecol. 2015; 28(2): e21-2. https://dx.doi.org/10.1016/j.jpag.2014.06.001.
  24. Egbe T.O., Kobenge F.M., Wankie E.M. Virginity-sparing management of hematocolpos with imperforate hymen: case report and literature review. SAGE Open Med. Case Rep. 2019; 7: 2050313X19846765. https://dx.doi.org/10.1177/2050313X19846765.
  25. Khashoggi A.A., Hakami N.A., Alghamdi M.A., Ayed H.Y., Alqarni A.D., Alshahrani T.J. et al. Hematocolpos: an unusual cause of right iliac fossa pain. Cureus. 2021; 13(10): e18835. https://dx.doi.org/10.7759/ cureus.18835.
  26. Mwenda A.S. Imperforate hymen - a rare cause of acute abdominal pain and tenesmus: case report and review of the literature. Pan Afr. Med. J. 2013; 15: 28. https://dx.doi.org/10.11604/pamj.2013.15.28.2251.
  27. Niang I., Diouf K.N., Thiam M., Ndong A., Diop C.T., Ka S. et al. Late diagnosis of imperforate hymen with hematometrocolpos and bilateral hydronephrosis of a horseshoe kidney. Radiol. Case Rep. 2020; 15(11): 2217-20. https://dx.doi.org/10.1016/j.radcr.2020.08.054.
  28. Юрасов И.В., Пестрикова Т.Ю. Воспалительные заболевания органов малого таза: современные аспекты тактики. Дальневосточный медицинский журнал. 2013; 1: 130-3. [Yurasov I.V., Pestrikova T.Yu. Inflammatory diseases of the small pelvic organs: current tactics. Far Eastern Medical Journal. 2013; (1): 130-3. (in Russian)].
  29. Acién P. Pathophysiological bases for the classification of the human sex development anomalies. Int. J. Med. Sci. Health Res. 2021; 5(1): 66-79. https://dx.doi.org/10.51505/IJMSHR.2021.5108.
  30. Васильев А.О., Говоров А.В., Пушкарь Д.Ю. Эмбриональные аспекты врожденных аномалий почек и мочевых путей (CAKUT-синдром). Вестник урологии. 2015; 2: 47-60. [Vasilyev A.O., Govorov A.V., Pushkar D.Yu. Embryological aspects of сongenital anomalies of the kidney and urinary tract (CAKUT): review. Bulletin of Urology. 2015; (2): 47-60. (in Russian)].
  31. Cunha G.R., Robboy S.J., Kurita T., Isaacson D., Shen J., Cao M., Baskin L.S. et al. Development of the human female reproductive tract. Differentiation. 2018; 103: 46-65. https://dx.doi.org/10.1016/j.diff.2018.09.001.
  32. Robboy S.J., Kurita T., Baskin L., Cunha G.R. New insights into human female reproductive tract development. Differentiation. 2017; 97: 9-22. https://dx.doi.org/10.1016/j.diff.2017.08.002.
  33. Roly Z.Y., Backhouse B., Cutting A., Tan T.Y., Sinclair A.H., Ayers K.L. et al. The cell biology and molecular genetics of Müllerian duct development. Wiley Interdiscip. Rev. Dev. Biol. 2018; 7(3): e310. https://dx.doi.org/10.1002/wdev.310.
  34. Алиева К.Х., Кохреидзе Н.А., Сухоцкая А.А., Баиров В.Г., Скрипник А.Ю. Синдром Herlyn–Werner–Wunderlich в препубертатном периоде (обзор литературы и клинические наблюдения). Андрология и генитальная хирургия. 2020; 21(4): 60-7. [Alieva K.Kh., Kokhreidze N.A., Sukhotskaya А.А., Bairov V.G., Skripnik A.Yu. Herlyn–Werner–Wunderlich syndrome in the prepubescent period (literature review and clinical observations). Andrology and Genital Surgery. 2020; 21(4): 60-7. (in Russian)]. https:/dx.doi.org/10.17650/2070-9781-2020-21-4-60-67.
  35. Клинические рекомендации (проект). Врожденные пороки развития влагалища и/или матки у детей и подростков. Репродуктивное здоровье детей и подростков. 2021; 17(3): 31-56. https://dx.doi.org/10.33029/ 1816-2134-2021-17-3-31-56.
  36. Russell V.R., Ibrahim M., Phillips G., Setchell T., Purkayastha S. Imperforate hymen mimicking acute appendicitis in an adolescent woman: a rare presentation. BMJ Case Rep. 2021; 14(3): e238547. https://dx.doi.org/10.1136/bcr-2020-238547.
  37. Fedele L., Frontino G., Motta F., Restelli E. A uterovaginal septum and imperforate hymen with a double pyocolpos. Hum. Reprod. 2012; 27(6): 1637-9. https://dx.doi.org/10.1093/humrep/des084.
  38. Löllgen R.M., Sabo J., Mettler A., Liniger B., Berger S. Unique presentation of hematometrocolpos mimicking cauda equina syndrome: severe back pain and urinary incontinence in an adolescent girl. J. Emerg. Med. 2016; 51(2): e19-23. https://dx.doi.org/10.1016/j.jemermed.2016.01.031.
  39. Tsatsaris G., Fasoulakis Z., Papapanagiotou I., Theodora M., Kontomanolis E.N. A rare case of massive hematometra with a tubo-ovarian abscess in a 16-year-old female. Cureus. 2019; 11(6): e4845. https://dx.doi.org/10.7759/cureus.4845.
  40. Кулаковский В.А., Зиганшин А.М., Кулавский Е.В. Клинические аспекты профилактики спаечного процесса при острых воспалительных заболеваниях органов малого таза у женщин. Акушерство и гинекология. 2019; 2: 14-20. [Kulavsky V.A., Ziganshin A.M., Kulavsky E.V. Prevention of adhesion in women with acute pelvic inflammatory diseases: clinical aspects. Obstetrics and Gynecology. 2019; (2): 14-20. (in Russian)]. https://dx.doi.org/10.18565/aig.2019.2.14-20.
  41. Пестрикова Т.Ю., Юрасов И.В., Юрасова Е.А. Воспалительные заболевания органов малого таза: современные тренды диагностики и терапии (обзор литературы). Гинекология. 2018; 20(6): 35-41. [Pestrikova T.Yu., Yurasov I.V., Yurasova E.A. Inflammatory disease of the womans reproductive system: modern trends in diagnosis and therapy (literature review). Gynecology. 2018; 20(6): 35-41. (in Russian)]. https://dx.doi.org/10.26442/ 20795696.2018.6.180072.
  42. Degheili J.A., Khaled M., Chouikh T., Aoun B. Pyocolpos: a rare cause of recurrent abdominal pain - always insist on a thorough physical examination. Radiol. Case Rep. 2022; 17(5): 1678-81. https://dx.doi.org/10.1016/j.radcr.2022.02.051.
  43. Wong J.W.H., Siarezi S. The dangers of hymenotomy for imperforate hymen: a case of iatrogenic pelvic inflammatory disease with pyosalpinx. J. Pediatr. Adolesc. Gynecol. 2019; 32(4): 432-5. https://dx.doi.org/10.1016/ j.jpag.2019.04.002.
  44. Chia M., Ho C. Missed diagnosis of imperforate hymen later presenting with hypertension. BMJ Case Rep. 2020; 13(9): e237416. https://dx.doi.org/10.1136/bcr-2020-237416.
  45. Rossi G.P., Bisogni V., Rossitto G., Maiolino G., Cesari M., Zhu R. et al. Practice Recommendations for diagnosis and treatment of the most common forms of secondary hypertension. High Blood Press. Cardiovasc. Prev. 2020; 27(6): 547-60. https://dx.doi.org/10.1007/s40292-020-00415-9.
  46. Dilbaz B., Kiykac Altinbas S., Altinbas N.K., Sengul O., Dilbaz S. Concomitant imperforate hymen and transverse vaginal septum complicated with pyocolpos and abdominovaginal fistula. Case Rep. Obstet. Gynecol. 2014; 2014: 406219. https://dx.doi.org/10.1155/2014/406219.
  47. Kakiuchi T., Azusa K. Imperforate hymen due to vaginal hypoplasia presenting as an acute abdomen in adolescence. Clin. Case Rep. 2021; 9(7): e04450. https://dx.doi.org/10.1002/ccr3.4450.
  48. Малгаждаров М.С., Мадьяров В.М., Турбекова М.Н. Эпидемиологические аспекты острого аппендицита по данным центральной городской клинической больницы города Алматы. Вестник Казахского Национального медицинского университета. 2021; 3: 399-403. [Malgazhdarov M.S., Madyarov V.M., Turbekova M.N. Epidemiological aspects of acute appendicitis according to the central city clinical hospital of Almaty. Bulletin of Kazakh National Medical University. 2021; (3): 399-403. (in Russian)]. https://dx.doi.org/10.53065/kaznmu.2021.53.66.077.
  49. Makris G.M., Macchiella D., Vaidakis D., Chrelias C., Battista MJ., Siristatidis C. Abdominal tumor in a 14-year-old adolescent: imperforate hymen, resulting in hematocolpos-a case report and review of the literature. Case Rep. Obstet. Gynecol. 2015; (2015): 429740. https://dx.doi.org/10.1155/2015/ 429740.
  50. Patwa P.A., Rathi R., Chaudhary K., Charan A., Singh R.K., Mishra G.V. A case series on imperforate hymen causing hematometra and hematocolpos with unusual presentations. J. Datta Meghe Institute Med. Sci. Univ. 2021; 16: 216-8. https://dx.doi.org/10.4103/jdmimsu.jdmimsu_130_2.

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